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PMID: 12028789 Published · ppublish English Journal Article Review

Protein synthesis in the dendrite.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 357 ·No. 1420 ·2002-04-29 ·Pages 521-9

Tang SJ, Schuman EM

Abstract

In neurons, many proteins that are involved in the transduction of synaptic activity and the expression of neural plasticity are specifically localized at synapses. How these proteins are targeted is not clearly understood. One mechanism is synaptic protein synthesis. According to this idea, messenger RNA (mRNA) translation from the polyribosomes that are observed at the synaptic regions provides a local source of synaptic proteins. Although an increasing number of mRNA species has been detected in the dendrite, information about the synaptic synthesis of specific proteins in a physiological context is still limited. The physiological function of synaptic synthesis of specific proteins in synaptogenesis and neural plasticity expression remains to be shown. Experiments aimed at understanding the mechanisms and functions f synaptic protein synthesis might provide important information about the molecular nature of neural plasticity.

MeSH Terms
Animals Dendrites/genetics,metabolism Humans Polyadenylation Protein Biosynthesis Proteins/genetics RNA Transport RNA, Messenger/metabolism Synapses/metabolism
Chemicals
Proteins RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tang Shao Jun
Howard Hughes Medical Institute, Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA. schumane@caltech.edu
Schuman Erin M
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Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
DOI
10.1098/rstb.2001.0887
Email
schumane@caltech.edu
Published
2002-04-29
Pages
521-9
Language
English
Region
England
NLM ID
7503623
PMCID
PMC1692956
Subset
IM
External Links
PubMed source DOI: 10.1098/rstb.2001.0887 PMC Full Text View journal details
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