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PMID: 11997347 Published · ppublish English Letter

Protein coding palindromes are a unique but recurrent feature in Rickettsia.

Genome research ·Vol. 12 ·No. 5 ·2002-05-00 ·Pages 808-16

Ogata H, Audic S, Abergel C, Fournier PE, Claverie JM

Abstract

Rickettsia are unique in inserting in-frame a number of palindromic sequences within protein coding regions. In this study, we extensively analyzed repeated sequences in the genome of Rickettsia conorii and examined their locations in regard to coding versus noncoding regions. We identified 656 interspersed repeated sequences classified into 10 distinct families. Of the 10 families, three palindromic sequence families showed clear cases of insertions into open reading frames (ORFs). The location of those in-frame insertions appears to be always compatible with the encoded protein three-dimensional (3-D) fold and function. We provide evidence for a progressive loss of the palindromic property over time after the insertions. This comprehensive study of Rickettsia repeats confirms and extends our previous observations and further indicates a significant role of selfish DNAs in the creation and modification of proteins.

MeSH Terms
Amino Acid Sequence/genetics Bacterial Proteins/chemistry,genetics Base Composition/genetics Base Sequence Computational Biology/methods Genome, Bacterial Molecular Sequence Data Protein Structure, Quaternary/genetics Rickettsia conorii/chemistry,genetics
Chemicals
Bacterial Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ogata Hiroyuki
Information Génétique & Structurale, CNRS-AVENTIS UMR 1889, 13402 Marseille Cedex 20, France. Hiroyuki.Ogata@igs.cnrs-mrs.fr
Audic Stéphane
Abergel Chantal
Fournier Pierre-Edouard
Claverie Jean-Michel
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Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.227602
Email
hiroyuki.ogata@igs.cnrs-mrs.fr
Published
2002-05-00
Pages
808-16
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC186582
Subset
IM
External Links
PubMed source DOI: 10.1101/gr.227602 PMC Full Text View journal details
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