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PMID: 11937490 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling.

Genes & development ·Vol. 16 ·No. 7 ·2002-04-01 ·Pages 820-35

Ring C, Ogata S, Meek L, Song J, Ohta T, Miyazono K, Cho KW

Abstract

We investigated the regulation of the activin/nodal-inducible distal element (DE) of the Xenopus goosecoid (gsc) promoter. On the basis of its interaction with the DE, we isolated a Xenopus homolog of the human Williams-Beuren syndrome critical region 11 (XWBSCR11), and further, show that it interacts with pathway-specific Smad2 and Smad3 in a ligand-dependent manner. Interestingly, we also find that XWBSCR11 functions cooperatively with FoxH1 (Fast-1) to stimulate DE-dependent transcription. We propose a mechanism in which FoxH1 functions together with Smads as a cofactor for the recruitment of transcription factors like XWBSCR11 in the process of activin/nodal-mediated gsc-specific induction. This mechanism provides considerable opportunities for modulation of transcription across a variety of activin/nodal-inducible genes, increasing diversity in promoter selection, thus leading to the differential induction of activin/nodal target genes.

MeSH Terms
Activins/metabolism Amino Acid Sequence Animals Base Sequence Basic Helix-Loop-Helix Transcription Factors COS Cells Cloning, Molecular DNA-Binding Proteins/metabolism Helix-Loop-Helix Motifs Humans Ligands Models, Biological Molecular Sequence Data Promoter Regions, Genetic Protein Binding Protein Structure, Tertiary Proteins/metabolism Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Signal Transduction Smad2 Protein Smad3 Protein Trans-Activators/metabolism Transcription Factors/chemistry,physiology Transcription, Genetic Williams Syndrome/metabolism Xenopus Xenopus Proteins/chemistry,physiology
Chemicals
Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins Ligands Proteins SMAD2 protein, human SMAD3 protein, human Smad2 Protein Smad2 protein, Xenopus Smad3 Protein Trans-Activators Transcription Factors WBSCR11 protein, Xenopus Xenopus Proteins madh3 protein, Xenopus Activins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Ring Colleen
Department of Developmental and Cell Biology, and Developmental Biology Center, University of California, Irvine, California 92697-2300, USA.
Ogata Souichi
Meek Lauren
Song Jihwan
Ohta Tatsuru
Miyazono Kohei
Cho Ken W Y
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.963802
Published
2002-04-01
Pages
820-35
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC186325
Subset
IM
Grants
NICHD NIH HHS · R01 HD029507 · United States
NICHD NIH HHS · HD29507 · United States
External Links
PubMed source DOI: 10.1101/gad.963802 PMC Full Text View journal details
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