Home LiteratureArticle Details

PMID: 9133442 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer.

Developmental biology ·Vol. 184 ·No. 2 ·1997-04-15 ·Pages 367-72

Joseph EM, Melton DA

Abstract

We have isolated a novel TGF beta-like gene from Xenopus which is highly related to mouse nodal The gene, Xnr4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord and neural tube. Ectopic expression of Xnr4 can induce and dorsalize mesoderm. These studies suggest that Xnr4, along with other nodal-related genes (Xnr1-3), may participate in mesodermal patterning and possibly neural development.

MeSH Terms

Amino Acid Sequence Animals Cloning, Molecular DNA Primers DNA, Antisense/genetics,metabolism Embryo, Nonmammalian/metabolism Embryonic Induction Gastrula/metabolism In Situ Hybridization Intercellular Signaling Peptides and Proteins Mesoderm/cytology Microinjections Molecular Sequence Data Nodal Protein Oocytes Proteins/chemistry,genetics,metabolism RNA, Messenger/metabolism Sequence Homology, Amino Acid Transforming Growth Factor beta Xenopus/embryology Xenopus Proteins

Chemicals

DNA Primers DNA, Antisense Intercellular Signaling Peptides and Proteins NODAL protein, Xenopus Nodal Protein Nodal protein, mouse Proteins RNA, Messenger Transforming Growth Factor beta Xenopus Proteins cer1 protein, Xenopus

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Joseph E M

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Melton D A

Article Info

Journal

Developmental biology

Abbr.

Dev Biol

ISSN

0012-1606

DOI

10.1006/dbio.1997.8510

Published

1997-04-15

Pages

367-72

Language

English

Region

United States

NLM ID

0372762

Subset

Databases

GENBANK

U79162

External Links

PubMed source DOI: 10.1006/dbio.1997.8510 View journal details

Analysis Services

Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer.

Contact

WeChat Official Account