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PMID: 11600350 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Family of class 1 integrons related to In4 from Tn1696.

Antimicrobial agents and chemotherapy ·Vol. 45 ·No. 11 ·2001-11-00 ·Pages 3014-20

Partridge SR, Recchia GD, Stokes HW, Hall RM

Abstract

The class 1 integron In28, found in the multidrug resistance transposon Tn1403, was found to be located in the res site of the backbone transposon and is flanked by a 5-bp direct duplication, indicating that it reached this position by transposition. In28 has a backbone structure related to that of In4, but has lost internal sequences, including the sul1 gene, due to an IS6100-mediated deletion. In28 also lacks the partial copy of IS6100 found in In4 and contains different gene cassettes, blaP1, cmlA1, and aadA1. In1, the class 1 integron found in the multidrug resistance plasmid R46, is also located in a putative res site and belongs to the In4 group. In1 has a shorter internal deletion than In28 and has also lost one end. Additional integrons with structures related to In4 were also found in databases, and most of them had also lost either one end or internal regions or both. Tn610 belongs to this group.

MeSH Terms
Base Sequence DNA, Bacterial/genetics,isolation & purification DNA-Binding Proteins/genetics Drug Resistance Escherichia coli/genetics Integrins/genetics Molecular Sequence Data Plasmids/genetics Pseudomonas aeruginosa/drug effects,genetics Reverse Transcriptase Polymerase Chain Reaction Salmonella typhimurium/drug effects,genetics
Chemicals
DNA, Bacterial DNA-Binding Proteins In4 complex Integrins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Partridge S R
CSIRO Molecular Science, North Ryde, New South Wales 2113, Australia.
Recchia G D
Stokes H W
Hall R M
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.45.11.3014-3020.2001
Published
2001-11-00
Pages
3014-20
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC90776
Subset
IM
Corrections
CommentIn
PMID: 12019143
External Links
PubMed source DOI: 10.1128/AAC.45.11.3014-3020.2001 PMC Full Text View journal details
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