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PMID: 11313007 Published · ppublish English Journal Article Review

Simian homologues of Epstein-Barr virus.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 356 ·No. 1408 ·2001-04-29 ·Pages 489-97

Wang F, Rivailler P, Rao P, Cho Y

Abstract

Gamma-herpesviruses closely related to the Epstein-Barr virus (EBV) are known to naturally infect Old World non-human primates and are classified in the same lymphocryptovirus (LCV) genera. LCV infecting humans and Old World primates share similar biology, and recent studies have demonstrated that these viruses share a similar repertoire of viral genes. Surprisingly, the latent infection genes associated with cell growth transformation demonstrate the most striking sequence divergence, but the functional mechanisms for these genes are generally well conserved. The recent discovery of LCVs naturally infecting New World primates has rewritten the old paradigm of LCV host range restriction to humans and Old World non-human primates, so that these viruses are more widespread than previously believed. However, the New World LCV genome has significant and interesting differences from EBV and other Old World LCVs despite similar biological properties. Thus, the simian homologues of EBV can provide an important animal model for studying LCV pathogenesis, and the similarities and differences that have evolved among these related viruses can provide a unique perspective towards a better understanding of EBV.

MeSH Terms
Animals Genes, Viral Haplorhini Herpesviridae Infections/virology Herpesvirus 4, Human Humans Lymphocryptovirus/genetics,physiology Tumor Virus Infections/virology Virus Latency
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wang F
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. fwang@rics.bwh.harvard.edu
Rivailler P
Rao P
Cho Y
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Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
DOI
10.1098/rstb.2000.0776
Email
fwang@rics.bwh.harvard.edu
Published
2001-04-29
Pages
489-97
Language
English
Region
England
NLM ID
7503623
PMCID
PMC1088440
Subset
IM
Corrections
CommentIn
PMID: 11313014
External Links
PubMed source DOI: 10.1098/rstb.2000.0776 PMC Full Text View journal details
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