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PMID: 11158621 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

An Epstein-Barr-related herpesvirus from marmoset lymphomas.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 3 ·2001-01-30 ·Pages 1224-9

Cho Y, Ramer J, Rivailler P, Quink C, Garber RL, Beier DR, Wang F

Abstract

Epstein-Barr virus (EBV) is implicated in the development of human B cell lymphomas and carcinomas. Although related oncogenic herpesviruses were believed to be endemic only in Old World primate species, we now find these viruses to be endemic in New World primates. We have isolated a transforming, EBV-related virus from spontaneous B cell lymphomas of common marmosets (Callithrix jacchus). Sequencing of two-thirds of the genome reveals considerable divergence from the genomes of EBV and Old World primate EBV-related viruses, including differences in genes important for virus-induced cell growth transformation and pathogenesis. DNA related to the C. jacchus herpesvirus is frequently detected in squirrel monkey peripheral blood lymphocytes, indicating that persistent infection with EBV-related viruses is prevalent in both New World primate families. Understanding how these more divergent EBV-related viruses achieve similar biologic outcomes in their natural host is likely to provide important insights into EBV infection, B cell growth transformation, and oncogenesis.

MeSH Terms
Amino Acid Sequence Animals Callithrix Cloning, Molecular DNA, Viral/genetics Gammaherpesvirinae/classification,genetics,isolation & purification Genetic Variation Genome, Viral Glutathione Transferase/genetics Herpesvirus 4, Human/classification,genetics,isolation & purification Herpesvirus 8, Human/genetics Humans Lymphoma, B-Cell/veterinary,virology Molecular Sequence Data Open Reading Frames Phylogeny Primate Diseases/virology Saimiri Sequence Alignment Sequence Homology, Amino Acid Transfection Tumor Cells, Cultured
Chemicals
DNA, Viral Glutathione Transferase
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Cho Y
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ramer J
Rivailler P
Quink C
Garber R L
Beier D R
Wang F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.98.3.1224
Published
2001-01-30
Pages
1224-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC14736
Subset
IM
Grants
NCRR NIH HHS · P51 RR000167 · United States
NCI NIH HHS · CA65319 · United States
NCI NIH HHS · R01 CA068051 · United States
NCRR NIH HHS · RR00167 · United States
NCRR NIH HHS · P51 RR000168 · United States
NCRR NIH HHS · P51RR00168 · United States
NCI NIH HHS · CA68051 · United States
Databases
GENBANK
AF319782
External Links
PubMed source DOI: 10.1073/pnas.98.3.1224 PMC Full Text View journal details
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