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PMID: 111244 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Hemoglobin ontogeny during normal mouse fetal development.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 6 ·1979-06-00 ·Pages 2853-7

Brotherton TW, Chui DH, Gauldie J, Patterson M

Abstract

Pure populations of large, nucleated erythrocytes derived from yolk sac blood islands were obtained during normal fetal mouse development. Embryonic hemoglobins were present in these cells early in gestation. Later in gestation, an increasing amount of adults hemoglobin was also synthesized and accumulated in this population of primitive nucleated erythrocytes, as demonstrated by both biochemical and immunocytochemical techniques.

MeSH Terms
Animals Erythrocytes/metabolism Female Fetus/metabolism Hemoglobins/biosynthesis Immunodiffusion Male Mice Mice, Inbred Strains Yolk Sac/physiology
Chemicals
Hemoglobins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brotherton T W
Chui D H
Gauldie J
Patterson M
References (20)
20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.6.2853
Published
1979-06-00
Pages
2853-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC383707
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.6.2853 PMC Full Text View journal details
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