Fetal hemoglobin variants in mice.

Science (New York, N.Y.) ·Vol. 160 ·No. 3830 ·1968-05-24 ·Pages 885-6

Gilman JG, Smithies O

Abstract

Two strains of mice, DBA and C3H, have a fetal globin polypeptide chain which differs in electrophoretic mobility from the corresponding fetal chain of the C57B1 strain. Mice of the DBA and C3H strains also differ from those of the C57B1 in adult hemoglobin type. Results of backcrossing the (DBA x C57B1) hybrid to the C57B1 suggest that the fetal chain locus and the adult beta-chain locus are closely linked.

MeSH Terms

Alleles Animals Blood Protein Electrophoresis Chemical Phenomena Chemistry Embryo, Mammalian Fetal Hemoglobin/analysis Hemoglobins, Abnormal/analysis Hybridization, Genetic Mice Molecular Biology Peptides/analysis Recombination, Genetic

Chemicals

Hemoglobins, Abnormal Peptides Fetal Hemoglobin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Gilman J G

Smithies O

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.160.3830.885

Published

1968-05-24

Pages

885-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.160.3830.885 View journal details

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Fetal hemoglobin variants in mice.

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