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PMID: 11120888 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 1 ·2001-01-02 ·Pages 319-24

Margrie TW, Sakmann B, Urban NN

Abstract

In the mammalian main olfactory bulb (MOB), the release of glutamate from lateral dendrites of mitral cells onto the dendrites of granule cells evokes recurrent and lateral inhibition of mitral cell activity. Whole-cell voltage recordings in the mouse MOB in vivo and in vitro show that recurrent and lateral inhibition together control the number, duration, and onset of odor-evoked action potential (AP) firing in mitral cells. APs in mitral cells propagate into the lateral dendrites and evoke a transient increase in dendritic calcium concentration ([Ca2+]), which is decremental with distance from the soma, and increases with AP number. These results suggest that the extent of AP propagation in lateral dendrites of mitral cells, along with the concomitant dendritic Ca(2+) transient, controls the amplitude of lateral and recurrent inhibition and thus is a critical determinant of odor-specific AP patterns in the MOB.

MeSH Terms
Action Potentials/drug effects,physiology Animals Bicuculline/pharmacology Calcium/metabolism Dendrites/drug effects,physiology Evoked Potentials/drug effects,physiology Excitatory Amino Acid Antagonists/pharmacology Fluorescence In Vitro Techniques Mice Olfactory Bulb/cytology,drug effects,physiology Olfactory Receptor Neurons/cytology,drug effects,physiology Patch-Clamp Techniques Pentanols/pharmacology Rats Smell/drug effects,physiology
Chemicals
Excitatory Amino Acid Antagonists Pentanols amyl acetate Calcium Bicuculline
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Margrie T W
Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany. tmargrie@sun0.mpimf-heidelberg.mpg.de
Sakmann B
Urban N N
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.011523098
Email
tmargrie@sun0.mpimf-heidelberg.mpg.de
Published
2001-01-02
Pages
319-24
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC14588
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.011523098 PMC Full Text View journal details
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