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PMID: 10888667 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae.

Molecular biology of the cell ·Vol. 11 ·No. 7 ·2000-07-00 ·Pages 2267-81

Levine TP, Wiggins CA, Munro S

Abstract

The plasma membrane of eukaryotic cells differs in lipid composition from most of the internal organelles, presumably reflecting differences in many of its functions. In particular, the plasma membrane is rich in sphingolipids and sterols, one property of which is to decrease the permeability and increase the thickness of lipid bilayers. In this paper, we examine the length of transmembrane domains throughout the yeast secretory pathway. Although the transmembrane domains of cis and medial Golgi residents are similar to those of endoplasmic reticulum proteins, these domains lengthen substantially beyond the medial Golgi, suggesting a thickening of the bilayer. Yeast sphingolipids have particularly long acyl chains, and Aur1p, the inositol phosphorylceramide synthase that initiates yeast sphingolipid synthesis, was found to be located in the Golgi apparatus by both immunofluorescence and membrane fractionation, with its active site apparently in the Golgi lumen. Thus, it appears that sphingolipid synthesis in yeast takes place in the Golgi, separated from glycerophospholipid synthesis in the endoplasmic reticulum. A similar separation has been found in mammalian cells, and this conservation suggests that such an arrangement of enzymes within the secretory pathway could be important for the creation of bilayers of different thickness within the cell.

MeSH Terms
Amino Acid Sequence Golgi Apparatus/enzymology Hexosyltransferases/metabolism Molecular Sequence Data Saccharomyces cerevisiae/enzymology,metabolism Sequence Homology, Amino Acid Sphingolipids/biosynthesis
Chemicals
Sphingolipids Hexosyltransferases phosphatidylinositol-ceramide phosphoinositol transferase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Levine T P
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom.
Wiggins C A
Munro S
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Article Info
Journal
Molecular biology of the cell
Abbr.
Mol Biol Cell
ISSN
1059-1524
Published
2000-07-00
Pages
2267-81
Language
English
Region
United States
NLM ID
9201390
PMCID
PMC14918
Subset
IM
Analysis Services
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