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PMID: 10887519 Published · ppublish English Journal Article Review

Early mammary development: growth hormone and IGF-1.

Journal of mammary gland biology and neoplasia ·Vol. 2 ·No. 1 ·1997-01-00 ·Pages 49-57

Kleinberg DL

Abstract

The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1. This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth hormone and IGF-1.

MeSH Terms
Animals Breast/growth & development Estradiol/physiology Female Growth Hormone/physiology Humans Insulin-Like Growth Factor I/genetics,physiology Mammary Glands, Animal/growth & development RNA, Messenger/analysis Receptors, Somatotropin/physiology Sexual Maturation
Chemicals
RNA, Messenger Receptors, Somatotropin Estradiol Insulin-Like Growth Factor I Growth Hormone
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kleinberg D L
Department of Medicine, New York University Medical Center, New York 10010, USA.
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23 references, click to expand
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1026373513521
Published
1997-01-00
Pages
49-57
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1026373513521 View journal details
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