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PMID: 2825030 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Growth hormone receptor and serum binding protein: purification, cloning and expression.

Nature ·Vol. 330 ·No. 6148 ·1987-00-00 ·Pages 537-43

Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI

Abstract

A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Carrier Proteins/genetics,isolation & purification Cloning, Molecular DNA/isolation & purification,metabolism DNA Restriction Enzymes Growth Hormone/blood Liver/metabolism Molecular Sequence Data Rabbits Receptors, Somatotropin/genetics,isolation & purification Transcription, Genetic

Chemicals

Carrier Proteins Receptors, Somatotropin Growth Hormone DNA DNA Restriction Enzymes somatotropin-binding protein

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Leung D W

Department of Developmental Biology, Genentech, Inc., South San Francisco, California.

Spencer S A

Cachianes G

Hammonds R G

Collins C

Henzel W J

Barnard R

Waters M J

Wood W I

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/330537a0

Published

1987-00-00

Pages

537-43

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/330537a0 View journal details

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