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PMID: 10716929 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

BDNF regulates eating behavior and locomotor activity in mice.

The EMBO journal ·Vol. 19 ·No. 6 ·2000-03-15 ·Pages 1290-300

Kernie SG, Liebl DJ, Parada LF

Abstract

Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development. Ablation of this gene in mice leads to death shortly after birth, and abnormalities have been found in both the peripheral and central nervous systems. BDNF and its tyrosine kinase receptor, TrkB, are expressed in hypothalamic nuclei associated with satiety and locomotor activity. In heterozygous mice, BDNF gene expression is reduced and we find that all heterozygous mice exhibit abnormalities in eating behavior or locomotor activity. We also observe this phenotype in independently derived inbred and hybrid BDNF mutant strains. Infusion with BDNF or NT4/5 can transiently reverse the eating behavior and obesity. Thus, we identify a novel non-neurotrophic function for neurotrophins and indicate a role in behavior that is remarkably sensitive to alterations in BDNF activity.

MeSH Terms
Adipocytes/cytology Animals Appetite/genetics,physiology Body Weight/drug effects Brain-Derived Neurotrophic Factor/blood,deficiency,genetics,physiology Carrier Proteins/analysis Feeding Behavior/physiology Female Heterozygote Humans Hypothalamus/cytology,metabolism Insulin/blood Leptin/blood Male Mice Mice, Inbred Strains Mice, Knockout Motor Activity/genetics,physiology Nerve Tissue Proteins/analysis,genetics Neuropeptide Y/analysis Obesity/genetics,pathology RNA, Messenger/analysis,genetics Receptor, trkB/genetics Receptors, Cell Surface Receptors, Leptin
Chemicals
Brain-Derived Neurotrophic Factor Carrier Proteins Insulin Leptin Nerve Tissue Proteins Neuropeptide Y RNA, Messenger Receptors, Cell Surface Receptors, Leptin cocaine- and amphetamine-regulated transcript protein Receptor, trkB
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kernie S G
Center for Developmental Biology, U.T. Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75235-9133, USA.
Liebl D J
Parada L F
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/19.6.1290
Published
2000-03-15
Pages
1290-300
Language
English
Region
England
NLM ID
8208664
PMCID
PMC305670
Subset
IM
Grants
NCRR NIH HHS · P41 RR002584 · United States
NINDS NIH HHS · R37 NS033199 · United States
NCRR NIH HHS · P41-RR02584 · United States
NINDS NIH HHS · R01 NS33199-05 · United States
External Links
PubMed source DOI: 10.1093/emboj/19.6.1290 PMC Full Text View journal details
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