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PMID: 8584938 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.

Science (New York, N.Y.) ·Vol. 271 ·No. 5251 ·1996-02-16 ·Pages 994-6

Chua SC, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL

Abstract

Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db, rat fatty (a homolog of db), and the gene encoding the OB-R are the same gene.

MeSH Terms

Animals Base Sequence Blotting, Southern Carrier Proteins/genetics Chromosome Mapping Cloning, Molecular DNA Mutational Analysis Diabetes Mellitus/genetics Genetic Markers Leptin Mice Mice, Inbred C57BL Mice, Inbred Strains Molecular Sequence Data Obesity/genetics Phenotype Polymerase Chain Reaction Proteins/genetics Rats Rats, Inbred Strains Receptors, Cell Surface Receptors, Cytokine/genetics Receptors, Leptin

Chemicals

Carrier Proteins Genetic Markers Leptin Proteins Receptors, Cell Surface Receptors, Cytokine Receptors, Leptin leptin receptor, mouse

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Chua S C

Laboratory of Human Behavior and Metabolism, Rockefeller University, New York 10021, USA.

Chung W K

Wu-Peng X S

Zhang Y

Liu S M

Tartaglia L

Leibel R L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.271.5251.994

Published

1996-02-16

Pages

994-6

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIDDK NIH HHS · DK26687 · United States

NIDDK NIH HHS · DK47473 · United States

NICHD NIH HHS · HD28047 · United States

Databases

GENBANK

AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459, AF039460, AF039461

Corrections

CommentIn

PMID: 8584929

External Links

PubMed source DOI: 10.1126/science.271.5251.994 View journal details

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Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.

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