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PMID: 10681461 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 5 ·2000-02-29 ·Pages 2297-302

Liebl DJ, Klesse LJ, Tessarollo L, Wohlman T, Parada LF

Abstract

Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports survival of neurons that differentiate primarily into proprioceptors whereas nerve growth factor and brain-derived neurotrophic factor (BDNF) support subpopulations that transmit nociception and mechanoreception, respectively. We examined sensory neurons of gene-targeted mouse mutants at the NT-4, BDNF, NT-3, and TrkA loci. We show that NT-4 functions early in gangliogenesis, upstream of BDNF. In the absence of NT-4 function, BDNF-dependent, TrkB-expressing neurons fail to appear. The results are consistent with the model that precursor cells intended to become BDNF-dependent mechanoreceptors instead differentiate into NT-3-dependent proprioceptive neurons.

MeSH Terms
Animals Apoptosis Biomarkers Brain-Derived Neurotrophic Factor/genetics,metabolism Cell Count Ganglia, Spinal/cytology Gene Expression Mice Mice, Inbred C57BL Mice, Mutant Strains Nerve Growth Factors/genetics,physiology Neural Crest/cytology Neurons, Afferent/cytology Receptor, trkB/biosynthesis
Chemicals
Biomarkers Brain-Derived Neurotrophic Factor Nerve Growth Factors Receptor, trkB neurotrophin 4
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Liebl D J
Center for Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75235-9133, USA.
Klesse L J
Tessarollo L
Wohlman T
Parada L F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.040562597
Published
2000-02-29
Pages
2297-302
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC15795
Subset
IM
Grants
NINDS NIH HHS · R37 NS033199 · United States
NIGMS NIH HHS · T32 GM008203 · United States
NINDS NIH HHS · R01 NS 33199 · United States
NIGMS NIH HHS · T32GM08203 · United States
External Links
PubMed source DOI: 10.1073/pnas.040562597 PMC Full Text View journal details
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