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BLNK: a central linker protein in B cell activation.
Immunity. 1998 Jul;9(1):93-103
PMID: 9697839
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CH domains revisited.
FEBS Lett. 1998 Jul 17;431(2):134-7
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Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes.
Eur J Immunol. 1998 Aug;28(8):2320-30
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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
Cell. 1998 Jan 9;92(1):83-92
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Regulation of inositol lipid kinases by Rho and Rac.
Curr Opin Genet Dev. 1998 Feb;8(1):63-7
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Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases.
J Biol Chem. 1998 May 22;273(21):12779-85
PMID: 9582304
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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.
Curr Biol. 1998 May 7;8(10):554-62
PMID: 9601639
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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.
Curr Biol. 1998 May 7;8(10):563-72
PMID: 9601640
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T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation.
J Biol Chem. 1998 Jun 5;273(23):14218-24
PMID: 9603925
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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
Immunity. 1998 Aug;9(2):239-46
PMID: 9729044
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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3035-40
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Mitogen-activated protein kinases: specific messages from ubiquitous messengers.
Mol Cell Biol. 1999 Apr;19(4):2435-44
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Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors.
J Biol Chem. 1999 Mar 26;274(13):8506-15
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Role for the Rac1 exchange factor Vav in the signaling pathways leading to NK cell cytotoxicity.
J Immunol. 1999 Mar 15;162(6):3148-52
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Essential role of LAT in T cell development.
Immunity. 1999 Mar;10(3):323-32
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hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways.
Mol Cell Biol. 1999 May;19(5):3798-807
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Prolactin receptor signaling: shared components with the T-cell antigen receptor in Nb2 lymphoma cells.
Endocrine. 1998 Dec;9(3):313-20
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G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm).
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4826-31
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Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex.
J Biol Chem. 1996 Oct 25;271(43):26962-70
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A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains.
Nature. 1996 Dec 5;384(6608):481-4
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Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.
Immunity. 1996 Dec;5(6):591-604
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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.
Nature. 1997 Jan 9;385(6612):169-72
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Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases.
Curr Biol. 1996 Dec 1;6(12):1628-33
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Structure and function of vav.
Cell Signal. 1996 Dec;8(8):545-53
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Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
FEBS Lett. 1997 Jan 20;401(2-3):133-7
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Lck regulates Vav activation of members of the Rho family of GTPases.
Mol Cell Biol. 1997 Mar;17(3):1346-53
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Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.
J Exp Med. 1996 Sep 1;184(3):839-52
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p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.
J Exp Med. 1996 Sep 1;184(3):1161-6
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Expression of a novel isoform of Vav, Vav-T, containing a single Src homology 3 domain in murine testicular germ cells.
Oncogene. 1997 Feb 13;14(6):713-20
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Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.
Immunity. 1997 Feb;6(2):155-64
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Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway.
J Biol Chem. 1997 Apr 18;272(16):10751-5
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The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase.
Science. 1997 Apr 18;276(5311):418-20
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The VAV family of signal transduction molecules.
Crit Rev Oncog. 1996;7(1-2):65-88
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Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation.
J Cell Biol. 1997 Apr 21;137(2):387-98
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Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line.
J Biol Chem. 1995 Jun 2;270(22):13246-53
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Tyrosine phosphorylation of vav protooncogene product in primary human myelogenous leukemic cells stimulated by granulocyte colony-stimulating factor.
Biochem Biophys Res Commun. 1995 Jun 15;211(2):677-85
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A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.
Science. 1995 Jul 14;269(5221):242-4
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A functional T-cell receptor signaling pathway is required for p95vav activity.
Mol Cell Biol. 1995 Aug;15(8):4337-46
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Serum response factor: transcriptional regulation of genes induced by growth factors and differentiation.
Biochim Biophys Acta. 1995 Jul 28;1242(1):1-10
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Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.
Oncogene. 1995 Aug 17;11(4):619-25
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Interaction of smooth muscle calponin with phospholipids.
FEBS Lett. 1995 Sep 4;371(2):123-6
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TPO and IL-3 induce overlapping but distinct protein tyrosine phosphorylation in a myeloid precursor cell line.
Biochem Biophys Res Commun. 1995 Sep 14;214(2):424-31
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Signal transduction in T lymphocytes using a conditional allele of Sos.
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9810-4
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The proline-rich region of Vav binds to Grb2 and Grb3-3.
Oncogene. 1995 Oct 19;11(8):1665-9
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Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin.
J Biol Chem. 1995 Mar 31;270(13):7712-6
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A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor.
J Biol Chem. 1995 May 5;270(18):10960-7
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Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.
Ann Hum Genet. 1995 Jan;59(Pt 1):25-37
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PAK3 mutation in nonsyndromic X-linked mental retardation.
Nat Genet. 1998 Sep;20(1):25-30
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Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
Oncogene. 1998 Sep 17;17(11 Reviews):1415-38
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Mutagenic analysis of Vav reveals that an intact SH3 domain is required for transformation.
Oncogene. 1998 Sep 24;17(12):1597-606
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c-Cbl: a regulator of T cell receptor-mediated signalling.
Immunol Cell Biol. 1998 Oct;76(5):473-82
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Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells.
J Biol Chem. 1998 Nov 27;273(48):31932-8
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Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2.
EMBO J. 1998 Nov 16;17(22):6608-21
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Vav regulates peptide-specific apoptosis in thymocytes.
J Exp Med. 1998 Dec 7;188(11):2099-111
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Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76.
Immunity. 1998 Nov;9(5):607-16
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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
Immunity. 1998 Nov;9(5):617-26
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Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1.
Curr Biol. 1998 Dec 3;8(24):1289-99
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Thymocyte selection in Vav and IRF-1 gene-deficient mice.
Immunol Rev. 1998 Oct;165:149-66
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The Syk family of protein tyrosine kinases in T-cell activation and development.
Immunol Rev. 1998 Oct;165:167-80
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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.
Genes Dev. 1998 Dec 1;12(23):3663-74
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Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.
Mol Cell Biol. 1999 Jan;19(1):948-56
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Activation of Vav and Ras through the nerve growth factor and B cell receptors by different kinases.
Cell Immunol. 1999 Feb 1;191(2):83-9
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Adaptors and molecular scaffolds in immune cell signaling.
Cell. 1999 Jan 8;96(1):5-8
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BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells.
Immunity. 1999 Jan;10(1):117-25
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Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.
EMBO J. 1999 Feb 15;18(4):904-15
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A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.
J Biol Chem. 1999 Feb 26;274(9):5868-79
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Rac1 is required for the formation of three germ layers during gastrulation.
Oncogene. 1998 Dec 31;17(26):3427-33
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Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help.
Eur J Immunol. 1999 Feb;29(2):477-87
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Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.
Immunity. 1999 Feb;10(2):183-96
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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature. 1999 Mar 4;398(6722):84-90
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Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway.
J Immunol. 1999 Jul 15;163(2):802-10
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TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway.
J Immunol. 1999 Jul 15;163(2):844-53
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PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells.
Biochim Biophys Acta. 1999 Jul 8;1450(3):265-76
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Signal-regulated activation of serum response factor is mediated by changes in actin dynamics.
Cell. 1999 Jul 23;98(2):159-69
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N-terminally truncated Vav induces the formation of depolymerization-resistant actin filaments in NIH 3T3 cells.
FEBS Lett. 1999 Jul 16;455(1-2):123-9
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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
Science. 1999 Oct 8;286(5438):309-12
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Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins.
Mol Cell Biol. 1999 Nov;19(11):7870-85
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The small GTP-binding protein Rho potentiates AP-1 transcription in T cells.
Mol Cell Biol. 1998 Sep;18(9):4986-93
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Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors.
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):179-84
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A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation.
J Biol Chem. 2000 Jan 21;275(3):2185-90
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Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav.
Mol Cell Biol. 2000 Mar;20(5):1678-91
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vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.
EMBO J. 1989 Aug;8(8):2283-90
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Rho GTPases are over-expressed in human tumors.
Int J Cancer. 1999 May 31;81(5):682-7
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SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity.
J Biol Chem. 1999 Jun 4;274(23):16206-12
PMID: 10347175
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The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation.
Eur J Immunol. 1999 May;29(5):1709-18
PMID: 10359126
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CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation.
J Immunol. 1999 Jun 15;162(12):7088-94
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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
Int Immunol. 1999 Jun;11(6):943-50
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Signaling networks--do all roads lead to the same genes?
Cell. 1999 Jun 11;97(6):675-8
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CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13158-62
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Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.
Oncogene. 1997 Nov 20;15(21):2511-20
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The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway.
J Exp Med. 1997 Dec 15;186(12):1947-55
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Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling.
J Biol Chem. 1998 Jan 2;273(1):296-301
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Rho GTPases and the actin cytoskeleton.
Science. 1998 Jan 23;279(5350):509-14
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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav.
Science. 1998 Jan 23;279(5350):558-60
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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
Science. 1998 Jan 23;279(5350):560-3
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Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
Br J Cancer. 1998;77(1):147-52
PMID: 9459160
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Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes.
Mol Cell Biol. 1998 Mar;18(3):1725-35
PMID: 9488489
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CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.
Immunity. 1998 May;8(5):635-45
PMID: 9620684
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p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.
Science. 1998 Jun 26;280(5372):2109-11
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Colony-stimulating factor-1 stimulates the formation of multimeric cytosolic complexes of signaling proteins and cytoskeletal components in macrophages.
J Biol Chem. 1998 Jul 3;273(27):17128-37
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Membrane compartmentation is required for efficient T cell activation.
Immunity. 1998 Jun;8(6):723-32
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Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8193-8
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Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.
Science. 1998 Jul 17;281(5375):413-6
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Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.
Mol Cell Biol. 1998 Aug;18(8):4744-51
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The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing.
J Exp Med. 1998 Aug 3;188(3):549-59
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Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.
Cell. 1998 Jul 24;94(2):229-38
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CD19 regulates B lymphocyte responses to transmembrane signals.
Semin Immunol. 1998 Aug;10(4):267-77
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Vav links antigen-receptor signaling to the actin cytoskeleton.
Semin Immunol. 1998 Aug;10(4):317-27
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Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase.
Oncogene. 1994 Jun;9(6):1755-65
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Ternary complex factors: growth factor regulated transcriptional activators.
Curr Opin Genet Dev. 1994 Feb;4(1):96-101
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ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.
Science. 1994 Jun 10;264(5165):1599-601
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Vav binds to several SH2/SH3 containing proteins in activated lymphocytes.
Oncogene. 1994 Jul;9(7):1917-23
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Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor.
Oncogene. 1994 Aug;9(8):2405-13
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The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras.
J Exp Med. 1994 Sep 1;180(3):1067-76
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Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway.
Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8602-6
PMID: 8078929
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Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.
Mol Cell Biol. 1994 Oct;14(10):6848-57
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CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.
Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9347-51
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Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor.
Cell. 1994 Nov 18;79(4):669-78
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IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.
J Exp Med. 1994 Dec 1;180(6):2101-11
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Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor.
Blood. 1994 Dec 15;84(12):4135-41
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Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors.
J Biol Chem. 1994 Dec 23;269(51):32514-21
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The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav.
J Biol Chem. 1994 Dec 23;269(51):32579-85
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Binding of Vav to Grb2 through dimerization of Src homology 3 domains.
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12629-33
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Hematopoietic development of vav-/- mouse embryonic stem cells.
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12755-9
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The human VAV proto-oncogene maps to chromosome region 19p12----19p13.2.
Hum Genet. 1990 Nov;86(1):65-8
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Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.
Mol Cell Biol. 1991 Apr;11(4):1912-20
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Mechanism of activation of the vav protooncogene.
Cell Growth Differ. 1991 Feb;2(2):95-105
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Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates.
Nature. 1992 Mar 5;356(6364):68-71
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Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs.
Nature. 1992 Mar 5;356(6364):71-4
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Differential development of progenitor activity for three B-cell lineages.
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3320-4
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Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells.
Science. 1992 May 22;256(5060):1196-9
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Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.
J Biol Chem. 1992 Sep 5;267(25):18021-5
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Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck.
Biochem J. 1993 Sep 1;294 ( Pt 2):339-42
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Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells.
Mol Cell Biol. 1993 Oct;13(10):6572-85
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Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.
J Biol Chem. 1993 Nov 15;268(32):24442-8
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Proteins regulating Ras and its relatives.
Nature. 1993 Dec 16;366(6456):643-54
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Interferon alpha induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells.
J Biol Chem. 1994 Feb 4;269(5):3143-6
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2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.
Nature. 1994 Mar 3;368(6466):32-8
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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Mol Cell Biol. 1994 Apr;14(4):2777-85
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Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.
Oncogene. 1996 Jul 18;13(2):363-71
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Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.
Oncogene. 1996 Aug 1;13(3):455-60
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Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase.
J Biol Chem. 1996 Sep 6;271(36):22225-30
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Curr Opin Cell Biol. 1996 Apr;8(2):197-204
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The Dbl family of oncogenes.
Curr Opin Cell Biol. 1996 Apr;8(2):216-22
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Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase.
Biochem J. 1996 Sep 1;318 ( Pt 2):527-32
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Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation.
FEBS Lett. 1996 Oct 21;395(2-3):228-34
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Role of CD19 tyrosine 391 in synergistic activation of B lymphocytes by coligation of CD19 and membrane Ig.
J Immunol. 1997 Jun 15;158(12):5649-57
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Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.
J Immunol. 1997 Jul 1;159(1):70-6
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Signal transduction during natural killer cell activation: inside the mind of a killer.
Immunity. 1997 Jun;6(6):655-61
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Three domains of SLP-76 are required for its optimal function in a T cell line.
J Immunol. 1997 Aug 15;159(4):1639-47
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Rho GTPases and signaling networks.
Genes Dev. 1997 Sep 15;11(18):2295-322
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A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes.
Immunity. 1997 Oct;7(4):451-60
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The Janus protein tyrosine kinases in hematopoietic cytokine signaling.
Semin Immunol. 1995 Aug;7(4):247-54
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Does Vav bind to F-actin through a CH domain?
FEBS Lett. 1995 Oct 30;374(2):149-51
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TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules.
Biochem Biophys Res Commun. 1995 Nov 2;216(1):338-47
PMID: 7488109
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Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells.
Blood. 1995 Dec 15;86(12):4532-43
PMID: 8541543
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Thrombopoietin induces activation of at least two distinct signaling pathways.
FEBS Lett. 1995 Dec 27;377(3):497-501
PMID: 8549784
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Interaction of calponin with phospholipids.
J Biochem. 1995 May;117(5):999-1003
PMID: 8586646
-
Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product.
Exp Hematol. 1996 Apr;24(5):622-7
PMID: 8605967
-
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Cell. 1996 Mar 8;84(5):723-34
PMID: 8625410
-
Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets.
J Biol Chem. 1996 Mar 29;271(13):7544-50
PMID: 8631786
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The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.
J Biol Chem. 1996 Feb 16;271(7):3856-62
PMID: 8632004
-
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.
Immunity. 1996 Jun;4(6):593-602
PMID: 8673706
-
Transcription factors of the NFAT family: regulation and function.
Annu Rev Immunol. 1997;15:707-47
PMID: 9143705
-
The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction.
J Exp Med. 1997 May 19;185(10):1877-82
PMID: 9151714
-
Crystal structure of a calponin homology domain.
Nat Struct Biol. 1997 Mar;4(3):175-9
PMID: 9164454
-
The GTPase Rho has a critical regulatory role in thymus development.
EMBO J. 1997 May 1;16(9):2397-407
PMID: 9171353
-
CD40-triggered protein tyrosine phosphorylation on Vav and on phosphatidylinositol 3-kinase correlates with survival of the Ramos-Burkitt lymphoma B cell line.
Cell Immunol. 1997 May 1;177(2):119-28
PMID: 9178638
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Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.
EMBO J. 1995 Jan 16;14(2):257-65
PMID: 7530656
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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.
Nature. 1995 Mar 30;374(6521):467-70
PMID: 7700358
-
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene.
Nature. 1995 Mar 30;374(6521):470-3
PMID: 7700359
-
Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes.
Nature. 1995 Mar 30;374(6521):474-7
PMID: 7700360