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PMID: 2253939 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The human VAV proto-oncogene maps to chromosome region 19p12----19p13.2.

Human genetics ·Vol. 86 ·No. 1 ·1990-11-00 ·Pages 65-8

Martinerie C, Cannizzaro LA, Croce CM, Huebner K, Katzav S, Barbacid M

Abstract

A novel human oncogene, designated VAV, has been recently characterized. This oncogene was generated by a rearrangement within the 5' coding sequences of a normal cellular gene, the VAV proto-oncogene. The normal VAV gene is specifically expressed in hematopoietic cells regardless of their differentiation lineage. We now report that the VAV locus has been localized in the human genome at chromosome 19p12----19p13.2 by analysis of its segregation pattern in rodent-human somatic cell hybrids and by chromosomal in situ hybridization. The VAV locus might be closely linked to the insulin receptor (INSR) locus, as suggested by comigration of INSR and VAV high-molecular-weight DNA fragments after pulsed-field gel electrophoresis. The VAV chromosomal assignment is of interest because chromosome region 19p13 is involved in different karyotypic abnormalities in a variety of malignancies including melanomas and leukemias. The identification of a novel proto-oncogene that maps to that region will enable us to define whether VAV is involved in any of the translocations observed.

Related Genes
VAV
MeSH Terms
Animals Blotting, Southern Chromosome Mapping Chromosomes, Human, Pair 19 Cricetinae Genetic Markers Humans Hybrid Cells Oncogenes Proto-Oncogene Mas Proto-Oncogenes Receptor, Insulin/genetics
Chemicals
Genetic Markers MAS1 protein, human Proto-Oncogene Mas Receptor, Insulin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Martinerie C
Institut Curie, Centre Universitaire de Paris-Sud, Orsay, France.
Cannizzaro L A
Croce C M
Huebner K
Katzav S
Barbacid M
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00205175
Published
1990-11-00
Pages
65-8
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
Grants
NCI NIH HHS · CA21124 · United States
NCI NIH HHS · CA25875 · United States
NCI NIH HHS · CA39860 · United States
External Links
PubMed source DOI: 10.1007/BF00205175 View journal details
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