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PMID: 1065875 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Deposition of histone onto the replicating chromosome: newly synthesized histone is not found near the replication fork.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 7 ·1976-07-00 ·Pages 2266-9

Jackson V, Granner D, Chalkley R

Abstract

We have studied the site of deposition of newly synthesized histone. It appears to be randomly distributed over the chromosomal material and does not become associated specifically with immediately post-replicational DNA, nor is it deposited in discrete continuous regions distal to the sites of DNA synthesis. The newly synthesized DNA, however, rapidly acquires a complement of chromosomal proteins; presumably, preexisting histones must migrate to become associated with post-replicational DNA.

MeSH Terms

Cells, Cultured Chromatin/metabolism Chromosomes/metabolism DNA Replication Histones/metabolism

Chemicals

Chromatin Histones

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jackson V

Granner D

Chalkley R

References (16)

16 references, click to expand

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Proc Natl Acad Sci U S A. 1967 Nov;58(5):1977-83 PMID: 5237492
Histone synthesis in vitro on HeLa cell microsomes. The nature of the coupling to deoxyribonucleic acid synthesis.
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.73.7.2266

Published

1976-07-00

Pages

2266-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC430523

Subset

External Links

PubMed source DOI: 10.1073/pnas.73.7.2266 PMC Full Text View journal details

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Deposition of histone onto the replicating chromosome: newly synthesized histone is not found near the replication fork.

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