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PMID: 1064044 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 5 ·1976-05-00 ·Pages 1730-4

Hong SL, Levine L

Abstract

Serum stimulates the production of prostaglandins by transformed mouse fibroblasts. Hydrocortisone (cortisol) inhibits this stimulation. The half-maximal inhibition occurs at 6x10-9 M. Studies with cells labeled with [3H]arachidonic acid in their lipids show that the stimulation by serum results in the release of arachidonic acid from the cellular lipids, mostly phospholipids. Hydrocrotisone inhibits this release but does not inhibit the production of prostaglandins from exogenously supplied arachidonic acid. This inhibition of arachidonic acid release from phospholipids may be the mechanism for the anti-inflammatory action of corticosteroids.

MeSH Terms

Administration, Topical Adrenal Cortex Hormones/pharmacology Anti-Inflammatory Agents/pharmacology Arachidonic Acids/metabolism Blood Culture Media Hydrocortisone/pharmacology Indomethacin/pharmacology Prostaglandins/metabolism Prostaglandins E/biosynthesis Prostaglandins F/biosynthesis Time Factors

Chemicals

Adrenal Cortex Hormones Anti-Inflammatory Agents Arachidonic Acids Culture Media Prostaglandins Prostaglandins E Prostaglandins F Hydrocortisone Indomethacin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hong S L

Levine L

References (15)

15 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.73.5.1730

Published

1976-05-00

Pages

1730-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC430374

Subset

External Links

PubMed source DOI: 10.1073/pnas.73.5.1730 PMC Full Text View journal details

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Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

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