Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids.

British journal of pharmacology ·Vol. 46 ·No. 1 ·1972-09-00 ·Pages 172-5

Greaves MW, McDonald-Gibson W

Abstract

Homogenates of human breast skin form prostaglandins E(2) and F(2alpha) in the presence of arachidonic acid substrate. Significant inhibition of biosynthesis of prostaglandin E(2) and F(2alpha) was observed in the presence of the anti-inflammatory corticosteroid fluocinolone acetonide. This effect was dose-related. By contrast no significant inhibition was observed in the presence of an approximately equimolar concentration of hydrocortisone.Since prostaglandins have been recovered from several types of inflammatory reactions and are capable of mediating most of the components of inflammation the possibility arises that corticosteroids may owe their anti-inflammatory activity at least in part to inhibition of prostaglandin biosynthesis.

MeSH Terms

Arachidonic Acids/metabolism Breast Dose-Response Relationship, Drug Female Fluocinolone Acetonide/pharmacology Humans Hydrocortisone/pharmacology In Vitro Techniques Prostaglandins/biosynthesis Skin/drug effects,metabolism

Chemicals

Arachidonic Acids Prostaglandins Fluocinolone Acetonide Hydrocortisone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Greaves M W

McDonald-Gibson W

References (17)

17 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1972.tb06861.x

Published

1972-09-00

Pages

172-5

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1666109

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1972.tb06861.x PMC Full Text View journal details

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Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids.

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