Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids.

Nature ·Vol. 254 ·No. 5498 ·1975-03-27 ·Pages 308-11

Lewis GP, Piper PJ

Abstract

Corticosteroids as well as non-steroid anti-inflammatory drugs inhibit the prostaglandin-mediated vasodilatation accompanying lipolysis in subcutaneous fat. Whereas the non-steroids produce their effect by inhibition of prostaglandin synthesis, however, corticosteroids inhibit their release. This mechanism may be the basis of some actions of corticosteroids in inflammation, in the gastric mucosa and in the CNS.

MeSH Terms

Adipose Tissue/blood supply,metabolism Adrenocorticotropic Hormone/pharmacology Animals Betamethasone/pharmacology Biological Transport, Active/drug effects Blood Pressure/drug effects Blood Vessels/drug effects Female Glucocorticoids/pharmacology Hydrocortisone/pharmacology Lipid Metabolism Muscle Contraction/drug effects Muscle, Smooth/drug effects Prednisolone/pharmacology Prostaglandins/blood,metabolism,pharmacology Rabbits Regional Blood Flow/drug effects

Chemicals

Glucocorticoids Prostaglandins Adrenocorticotropic Hormone Betamethasone Prednisolone Hydrocortisone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lewis G P

Piper P J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/254308a0

Published

1975-03-27

Pages

308-11

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/254308a0 View journal details

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Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids.

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