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PMID: 10331663 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling.

Molecular and cellular biochemistry ·Vol. 192 ·No. 1-2 ·1999-02-00 ·Pages 95-103

Knudsen J, Jensen MV, Hansen JK, Faergeman NJ, Neergaard TB, Gaigg B

Abstract

Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and pool formation and therefore also for the function of LCAs as metabolites and regulators of cellular functions [1]. The major factors controlling the free concentration of cytosol long chain acylCoA ester (LCA) include ACBP [2], sterol carrier protein 2 (SCP2) [3] and fatty acid binding protein (FABP) [4]. Additional factors affecting the concentration of free LCA include feed back inhibition of the acylCoA synthetase [5], binding to acylCoA receptors (LCA-regulated molecules and enzymes), binding to membranes and the activity of acylCoA hydrolases [6].

MeSH Terms
Acyl Coenzyme A/analysis,metabolism Animals Carrier Proteins/physiology Cytosol/metabolism Diazepam Binding Inhibitor Escherichia coli/enzymology Gene Expression Regulation, Bacterial Gene Expression Regulation, Fungal Models, Biological Rats Saccharomyces cerevisiae/enzymology Sequence Homology, Amino Acid Signal Transduction Tissue Distribution
Chemicals
Acyl Coenzyme A Carrier Proteins Diazepam Binding Inhibitor
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Knudsen J
Biokemisk Institut, Odense Universitet, Denmark.
Jensen M V
Hansen J K
Faergeman N J
Neergaard T B
Gaigg B
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/978-1-4615-4929-1_11
Published
1999-02-00
Pages
95-103
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/978-1-4615-4929-1_11 View journal details
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