NUP98基因详情-基因数据库-基因云馆

NUP98 (nucleoporin 98 and 96 precursor)

symbol:: NUP98
locus group:: protein-coding gene
location:: 11p15.4
gene_family:
alias symbol:: NUP96|Nup98-Nup96|Nup98-96|NUP196
alias name:: Nuclear pore complex protein Nup...
entrez id:: 4928
ensembl gene id:: ENSG00000110713
ucsc gene id:: uc001lyh.3
refseq accession:: NM_016320
hgnc_id:: HGNC:8068
approved reserved:: 1997-07-04

11p15.4

NUP98（核孔蛋白98）是一种重要的核孔复合体蛋白，属于核孔蛋白（NUP）基因家族。该家族成员共同参与核孔复合体的形成，负责调控细胞核与细胞质之间的物质运输，包括RNA和蛋白质的转运。NUP98基因位于人类染色体11p15.4，编码的蛋白包含多个苯丙氨酸-甘氨酸（FG）重复序列，这些序列在核转运过程中与转运受体相互作用，帮助分子选择性通过核孔。NUP98在细胞分裂、基因表达调控和染色质组织中也发挥关键作用。NUP98的突变或异常表达与多种疾病相关，尤其是血液系统恶性肿瘤，如急性髓系白血病（AML）和骨髓增生异常综合征（MDS）。常见的致病机制是NUP98与其他基因（如HOXA9、PMX1等）发生融合，形成致癌融合蛋白，干扰正常造血分化并促进白血病发生。NUP98过表达可能破坏核转运平衡，影响细胞周期调控和凋亡，导致基因组不稳定；而表达降低则可能损害核质运输功能，影响细胞存活。此外，NUP98还参与病毒感染过程，某些病毒利用其FG重复区进入细胞核。该基因的突变或缺失在小鼠模型中会导致胚胎致死，表明其在发育中不可或缺。NUP98基因家族成员通常具有保守的FG重复结构域，并在核孔复合体组装和功能中发挥协同作用。

中文English

信号介导核进口和出口通过核孔复合物（NPC），它是由统称为核孔蛋白大约50个独特的蛋白质进行。 98 kDa的核孔蛋白是通过涉及合成和186 kDa的前体蛋白的蛋白水解切割一个生物合成途径产生。这两者在98 kDa的核孔蛋白这种分裂的结果，以及一个96 kDa的核孔蛋白，定位于全国的核质的一面。鼠的研究表明，在98 kDa的核孔蛋白功能的传输衬底的若干停靠站点核孔蛋白之一。人类基因已经显示熔合到下面的急性骨髓性白血病（AML）和T-细胞急性淋巴细胞性白血病（T-ALL）染色体易位的几个基因。该基因是位于11p15.5的印迹基因域，一个重要的肿瘤抑制基因区的几个基因中的一个。在这一区域的改变已与贝克威思-威德曼综合征，肾母细胞瘤，横纹肌肉瘤，肾上腺皮质癌和肺癌，卵巢癌和乳腺癌有关。在几个转录变异体本基因的结果的选择性剪接;然而，并非所有的变体已被充分地描述。 [由RefSeq的，2010年5月提供]

OMIM数据库中对NUP98基因的介绍 Wikipedia数据库中对NUP98基因的介绍

NUP98基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS
41AFGSSNNTGG LFGNSQTKPG GLFGTSSFSQ PATSTSTGFG
81
FGTSTGTAN TLFGTASTGT SLFSSQNNAF AQNKPTGFGN
121FGTSTSSGGL FGTTNTTSNP FGSTSGSLFG PSSFTAAPTG
161T
TIKFNPPT GTDTMVKAGV STNISTKHQC ITAMKEYESK
201SLEELRLEDY QANRKGPQNQ VGAGTTTGLF GSSPATSSAT
241GL
FSSSTTN SGFAYGQNKT AFGTSTTGFG TNPGGLFGQQ
281NQQTTSLFSK PFGQATTTQN TGFSFGNTST IGQPSTNTMG
321LFG
VTQASQ PGGLFGTATN TSTGTAFGTG TGLFGQTNTG
361FGAVGSTLFG NNKLTTFGSS TTSAPSFGTT SGGLFGNKPT
401LTLG
TNTNT SNFGFGTNTS GNSIFGSKPA PGTLGTGLGA
441GFGTALGAGQ ASLFGNNQPK IGGPLGTGAF GAPGFNTTTA
481TLGFG
APQA PVALTDPNAS AAQQAVLQQH INSLTYSPFG
521DSPLFRNPMS DPKKKEERLK PTNPAAQKAL TTPTHYKLTP
561RPATRV
RPK ALQTTGTAKS HLFDGLDDDE PSLANGAFMP
601KKSIKKLVLK NLNNSNLFSP VNRDSENLAS PSEYPENGER
641FSFLSKP
VD ENHQQDGDED SLVSHFYTNP IAKPIPQTPE
681SAGNKHSNSN SVDDTIVALN MRAALRNGLE GSSEETSFHD
721ESLQDDRE
E IENNSYHMHP AGIILTKVGY YTIPSMDDLA
761KITNEKGECI VSDFTIGRKG YGSIYFEGDV NLTNLNLDDI
801VHIRRKEVV
 VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD
841KTSRCLIKSP DRLADINYEG RLEAVSRKQG AQFKEYRPET
881GSWVFKVSHF 
SKYGLQDSD EEEEEHPSKT STKKLKTAPL
921PPASQTTPLQ MALNGKPAPP PQSQSPEVEQ LGRVVELDSD
961MVDITQEPVL D
TMLEESMP EDQEPVSAST HIASSLGINP
1001HVLQIMKASL LTDEEDVDMA LDQRFSRLPS KADTSQEICS
1041PRLPISASHS SK
TRSLVGG LLQSKFTSGA FLSPSVSVQE
1081CRTPRAASLM NIPSTSSWSV PPPLTSVFTM PSPAPEVPLK
1121TVGTRRQLGL VPR
EKSVTY GKGKLLMDMA LFMGRSFRVG
1161WGPNWTLANS GEQLNGSHEL ENHQIADSME FGFLPNPVAV
1201KPLTESPFKV HLEK
LSLRQ RKPDEDMKLY QTPLELKLKH
1241STVHVDELCP LIVPNLGVAV IHDYADWVKE ASGDLPEAQI
1281VKHWSLTWTL CEALW
GHLK ELDSQLNEPR EYIQILERRR
1321AFSRWLSCTA TPQIEEEVSL TQKNSPVEAV FSYLTGKRIS
1361EACSLAQQSG DHRLAL
LLS QFVGSQSVRE LLTMQLVDWH
1401QLQADSFIQD ERLRIFALLA GKPVWQLSEK KQINVCSQLD
1441WKRSLAIHLW YLLPPTA
SI SRALSMYEEA FQNTSDSDRY
1481ACSPLPSYLE GSGCVIAEEQ NSQTPLRDVC FHLLKLYSDR
1521HYDLNQLLEP RSITADPL
D YRLSWHLWEV LRALNYTHLS
1561AQCEGVLQAS YAGQLESEGL WEWAIFVLLH IDNSGIREKA
1601VRELLTRHCQ LLETPESWA
 KETFLTQKLR VPAKWIHEAK
1641AVRAHMESDK HLEALCLFKA EHWNRCHKLI IRHLASDAII
1681NENYDYLKGF LEDLAPPERS 
SLIQDWETS GLVYLDYIRV
1721IEMLRHIQQV DCSGNDLEQL HIKVTSLCSR IEQIQCYSAK
1761DRLAQSDMAK RVANLLRVVL S
LHHPPDRT SDSTPDPQRV
1801PLRLLAPHIG RLPMPEDYAM DELRSLTQSY LRELAVGSL

结构预测来自 AlphaFold DB（UniProt: P52948），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

NUP98基因的碱基突变：仅显示部分snp

rs6578411 rs138052155 rs143192527 rs148265174 rs149081028 rs185167425 rs189463410 rs192460650 rs369161940 rs530876048 rs534533556 rs535524767 rs540496460 rs544693097 rs558042330 rs562295045 rs562926605

NUP98基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TGTCTCTGTGCAAGAATGTC

58

GACTCAGTTAGGCAAGAGGA

59

AACATAAGTACCAAGCACCA

57

ATCCTCTAAACGAAGTTCCTC

57

CATCTTTGCTCTGTTGGCT

59

GGAGCACACGTTTATTTGC

58

GGTTCAAGCGATTCTCCTG

59

AGAGCAAGACGATGATCCC

59

TGAGTAGCTGGGATTACAGG

59

TGGCTACCCACAAACTGAG

60

CAACTCAGGCATACGTGAG

58

CTCTTTAGCCCAAGATTCAGG

59

GTCACATCTCTTTGATGGGC

59

TTCTTAATGCTCTTCTTGGGC

59

CAGAAGCACAAATTGTGAAGC

59

TGTCAAGCTCCTTCAGGTG

60

CCATCTATGGATGACCTTGC

58

AACCATAACCTTTCCGACC

57

ATTTGGAACAGCTCTTGGTG

59

AAAGGCTCCTGTACCAAGAG

60

尚未收录相关数据

NUP98基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

NUP98基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000059

P52948 (UniProtKB)

NAS

GO:0000973

P52948 (UniProtKB)

IBA

GO:0003723

P52948 (UniProtKB)

IBA

GO:0005215

P52948 (UniProtKB)

TAS

GO:0005487

P52948 (UniProtKB)

IBA

GO:0005515

P52948 (UniProtKB)

IPI

GO:0005515

P52948 (UniProtKB)

IPI

GO:0005515

P52948 (UniProtKB)

IPI

GO:0005515

P52948 (UniProtKB)

IPI

GO:0005635

P52948 (UniProtKB)

IDA

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005635

P52948 (UniProtKB)

TAS

GO:0005643

P52948 (UniProtKB)

NAS

GO:0005643

P52948 (UniProtKB)

IDA

GO:0005643

P52948 (UniProtKB)

IDA

GO:0005643

P52948 (UniProtKB)

IDA

GO:0005654

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0005829

P52948 (UniProtKB)

TAS

GO:0006260

P52948 (UniProtKB)

IMP

GO:0006405

P52948 (UniProtKB)

IBA

GO:0006406

P52948 (UniProtKB)

TAS

GO:0006406

P52948 (UniProtKB)

TAS

GO:0006406

P52948 (UniProtKB)

TAS

GO:0006409

P52948 (UniProtKB)

TAS

GO:0006913

P52948 (UniProtKB)

TAS

GO:0006999

P52948 (UniProtKB)

NAS

GO:0007062

P52948 (UniProtKB)

TAS

GO:0007077

P52948 (UniProtKB)

TAS

GO:0008139

P52948 (UniProtKB)

IBA

GO:0010827

P52948 (UniProtKB)

TAS

GO:0016032

P52948 (UniProtKB)

TAS

GO:0016925

P52948 (UniProtKB)

TAS

GO:0016925

P52948 (UniProtKB)

TAS

GO:0016925

P52948 (UniProtKB)

TAS

GO:0017056

P52948 (UniProtKB)

IMP

GO:0017056

P52948 (UniProtKB)

NAS

GO:0019083

P52948 (UniProtKB)

TAS

GO:0031047

P52948 (UniProtKB)

TAS

GO:0031080

P52948 (UniProtKB)

NAS

GO:0031080

P52948 (UniProtKB)

IDA

GO:0031965

P52948 (UniProtKB)

IDA

GO:0031965

P52948 (UniProtKB)

IDA

GO:0031965

P52948 (UniProtKB)

IDA

GO:0031965

P52948 (UniProtKB)

IDA

GO:0034398

P52948 (UniProtKB)

IBA

GO:0034399

P52948 (UniProtKB)

IDA

GO:0034399

P52948 (UniProtKB)

IDA

GO:0042405

P52948 (UniProtKB)

IDA

GO:0044614

P52948 (UniProtKB)

IBA

GO:0044615

P52948 (UniProtKB)

IDA

GO:0051292

P52948 (UniProtKB)

IMP

GO:0075733

P52948 (UniProtKB)

TAS

GO:1900034

P52948 (UniProtKB)

TAS

GO:0000776

P52948 (UniProtKB)

IDA

可能调控 NUP98基因的相关microRNA：

hsa-miR-34a hsa-miR-98 hsa-miR-149 hsa-miR-16 hsa-miR-18a* hsa-miR-30a* hsa-miR-652

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
3013 RNA transport [PATH:hsa03013]
5164 Influenza A [PATH:hsa05164]

名称
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to stress
Cytokine Signaling in Immune system
Disease
Export of Viral Ribonucleoproteins from Nucleus
Gene Expression
Glucose transport
Hexose transport
HIV Infection
HIV Life Cycle
Host Interactions of HIV factors
Immune System
Infectious disease
Influenza Infection
Influenza Life Cycle
Influenza Viral RNA Transcription and Replication
Interactions of Rev with host cellular proteins
Interactions of Vpr with host cellular proteins
Interferon Signaling
ISG15 antiviral mechanism
Late Phase of HIV Life Cycle
M Phase
Metabolism of carbohydrates
Metabolism of non-coding RNA
Metabolism of proteins
Mitotic Anaphase
Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Mitotic Prophase
NEP/NS2 Interacts with the Cellular Export Machinery
Nuclear Envelope Breakdown
Nuclear import of Rev protein
Nuclear Pore Complex (NPC) Disassembly
Post-translational protein modification
Processing of Capped Intron-Containing Pre-mRNA
Regulation of Glucokinase by Glucokinase Regulatory Protein
Regulation of HSF1-mediated heat shock response
Regulatory RNA pathways
Resolution of Sister Chromatid Cohesion
Rev-mediated nuclear export of HIV RNA
RHO GTPase Effectors
RHO GTPases Activate Formins
Separation of Sister Chromatids
Signaling by Rho GTPases
SLC-mediated transmembrane transport
snRNP Assembly
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of DNA damage response and repair proteins
Transcriptional regulation by small RNAs
Transmembrane transport of small molecules
Transport of Mature mRNA derived from an Intron-Containing Transcript
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNAs Derived from Intronless Transcripts
Transport of Mature Transcript to Cytoplasm
Transport of Ribonucleoproteins into the Host Nucleus
Transport of the SLBP Dependant Mature mRNA
Transport of the SLBP independent Mature mRNA
Viral Messenger RNA Synthesis
Vpr-mediated nuclear import of PICs

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Leukemia, Myelocytic, Acute	0.160242918	83	0	BeFree_CTD_human_LHGDN
MYELODYSPLASTIC SYNDROME	0.008977445	14	0	BeFree_LHGDN
leukemia	0.00842463	22	0	BeFree_LHGDN
Leukemogenesis	0.005157396	19	0	BeFree
Myeloid Leukemia, Chronic	0.004614512	17	0	BeFree
Myeloid Leukemia	0.004353001	6	0	BeFree_LHGDN
Preleukemia	0.003800186	14	0	BeFree
Hematologic Neoplasms	0.003528744	13	0	BeFree
HIV Infections	0.00272435	1	0	LHGDN
Acute leukemia	0.002442977	9	0	BeFree

Preferential formation of NUP98-KDM5A condensates at specific H3K4me3-rich loci drives leukemogenic gene expression.

Berrocal A, Sandoval JE, Khetan N, Ma A, Wang T, Moore C, Narlikar GJ, Li H, Fujimori DG, Huang B bioRxiv 2026-03-17

The Therapeutic Administration of Lactobacillus brevis ZG2488 Suppresses Influenza A Virus Replication Through a Viability-Dependent Host Transcriptional Modulation Mechanism.

Chen M, Chen Y, Cao Z, Ren Z, Yue K, Yang J, Pu J, Luo W, Xu J Microorganisms 2026-03-05

Identification and validation of SUMOylation-related key genes for osteoarthritis through integration of single-cell, bulk RNA sequencing and animal model experiments.

Liu A, Yang Y, Xiang J, Hu Y, Yang J, Zhang Y, Deng Y, Chen Y Front Med (Lausanne) None

HIF-1α impairs NK cell differentiation-maturation and cytotoxicity in myelodysplastic syndrome via JAK1/STAT5/SOCS2 pathway.

Xu S, Jiang Y, Wang S, Chen B, Lin W, Jiang F, Wu X, Tang R, Nie Y, Chen T, Wang X J Immunol IF: 4.0 2026-04-15

Rare NUP98::SETBP1 fusion transcript in a refractory adult T-cell lymphoblastic lymphoma.

Chen X, Wang L, Zou J, Zhou J, Zhou Y, Zuo M, Hu L, Dong X, Ke P, Hou J Am J Cancer Res IF: 3.1 None

Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation.

Bruzzese A, Vigna E, Martino EA, Caserta S, Mendicino F, Alvaro ME, Labanca C, Lucia E, Olivito V, Skafi M, Amodio N, Morabito F, Gentile M Eur J Haematol IF: 2.6 2026-07-00

[Mechanism of Sanzi Huangshi Pill in Treating MDS and Downregulating NRAS Gene Expression].

Dong XJ, Tao YC, Ni RF, Jin R, Lu JH Zhongguo Shi Yan Xue Ye Xue Za Zhi 2026-02-00

Acute leukemia with BCL11B rearrangements: Genetic landscape, BCL11B expression, and therapeutic response.

Tang G, Wang SA, Jen WY, Medeiros LJ, Wang W, Fang H, Hu S, Jain N, Jabbour EJ, Zou YS, Xu J Hum Pathol IF: 3.0 2026-05-00

Role and insights of human papillomavirus E5 oncoprotein in cervical carcinogenesis.

Rani J, Sisodiya S, Kumar K, Kumar S, Khan A, Gupta E, Hussain S Exp Ther Med IF: 2.2 2026-09-00

All-Oral Combination of Revumenib, Decitabine, and Venetoclax for Relapsed or Refractory AML (SAVE).

Issa GC, Cuglievan B, El Hajjar G, Jen WY, Bataller A, Short NJ, DiNardo CD, Alvarado Y, Loghavi S, Duose DY, Zhang B, Furudate K, Ning J, Xiao L, Mouhayar E, Pinto A, Bidikian A, Thompson E, Daver N, Garcia-Manero G, Farhat A, McCall D, Kadia TM, Abbas HA, Tan S, Bazinet A, Jabbour E, Montalban-Bravo G, Ravandi F, Takahashi K, Andreeff M, Kantarjian HM J Clin Oncol IF: 44.7 2026-08-00

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NUP98 (nucleoporin 98 and 96 precursor)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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