Chromosomal translocations involving NUP98 generate fusion proteins that alter gene expression programs, yet the fundame...
...NUP98, EIF2S1) and a delayed interferon-beta (IFNB1) induction. In contrast, preventive effects appeared to be mediated ...
...NUP98 and TOP1 were identified as key genes. Later, the two key genes were co-enriched in multiple pathways, like "ribos...
...NUP98/HOXD13 (NHD13) mice. Our results demonstrated a significant increase in HIF-1α expression in the bone marrow and p...
...NUP98) gene. The NUP98::SETBP1 fusion gene was first reported in a de novo T-cell acute lymphoblastic leukemia (T-ALL) p...
...NUP98 rearrangements and UBTF tandem duplications, broadening the therapeutic relevance of menin inhibition. Menin acts ...
...NUP98-HOXD13 transgenic mice were regarded as the model group, SZHSP-ST group, and SZHSP group, respectively. The contro...
...NUP98, triggering nuclear pore complex (NPC) degradation. We present here the structural and biochemical basis of NUP98 ...
...NUP98 and NUP214, are recurrent in acute myeloid leukemia (AML). However, the intrinsic functions of wild-type nucleopor...
...NUP98re with a median age of 19 years compared with 62 years for the cases with no NUP98 rearrangement (NUP98wt) (p < 0....
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