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The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质在细胞因子刺激的内皮细胞被发现,被认为是负责血液白细胞中的通过介导的血管衬里的细胞的粘附炎症部位的积累。它表现出的结构特征如凝集素和EGF样结构域后跟短一致重复(SCR),该含有6个保守的半胱氨酸残基结构域的存在。这些蛋白是选择素家族细胞粘附分子的一部分。粘附分子参与白细胞和内皮之间的相互作用并似乎参与动脉粥样硬化的发病机制。 [由RefSeq的,2008年7月提供]
SELE基因(以及对应的蛋白质)的细胞分布位置:
SELE基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Reperfusion Injury | 0.2 | 3 | 0 | CTD_human_RGD |
Cardiovascular Diseases | 0.133278246 | 10 | 1 | BeFree_CTD_human_GAD_LHGDN |
Hypercholesterolemia | 0.128358616 | 3 | 0 | BeFree_CTD_human_GAD_LHGDN |
IGA Glomerulonephritis | 0.125362824 | 2 | 0 | BeFree_CTD_human_GAD_LHGDN |
Multiple Sclerosis | 0.125005506 | 3 | 0 | BeFree_CTD_human_GAD |
Brain Ischemia | 0.124734064 | 3 | 0 | CTD_human_GAD |
Dermatitis, Atopic | 0.122995792 | 2 | 0 | BeFree_CTD_human_LHGDN |
Atrial Fibrillation | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
Myocardial Ischemia | 0.122367032 | 2 | 0 | CTD_human_GAD |
Essential Hypertension | 0.121357209 | 5 | 0 | BeFree_CTD_human |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Urticaria | 0.12 | 1 | 0 | CTD_human |
Dermatitis, Allergic Contact | 0.12 | 1 | 0 | CTD_human |
Coronary Artery Disease | 0.024165715 | 16 | 9 | BeFree_GAD_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.018912512 | 12 | 0 | BeFree_GAD_LHGDN |
Myocardial Infarction | 0.016188161 | 9 | 0 | BeFree_GAD_LHGDN |
Atherosclerosis | 0.014168516 | 18 | 0 | BeFree_GAD_LHGDN |
Kidney Failure, Chronic | 0.01372144 | 6 | 0 | BeFree_GAD_LHGDN |
Neoplasm Metastasis | 0.013330446 | 22 | 0 | BeFree_LHGDN |
Coronary Arteriosclerosis | 0.013268314 | 16 | 0 | BeFree_GAD |
Inflammation | 0.012192478 | 5 | 0 | GAD_LHGDN |
Rheumatoid Arthritis | 0.012168734 | 8 | 0 | BeFree_GAD_LHGDN |
Hypertensive disease | 0.010911214 | 7 | 0 | BeFree_GAD_LHGDN |
Coronary heart disease | 0.009077134 | 18 | 0 | BeFree_GAD |
Cerebrovascular accident | 0.008729747 | 7 | 0 | BeFree_GAD |
Lupus Erythematosus, Systemic | 0.008358616 | 3 | 0 | BeFree_GAD_LHGDN |
Colorectal Cancer | 0.008186863 | 6 | 0 | BeFree_GAD |
Sarcoidosis | 0.007729856 | 2 | 0 | BeFree_GAD_LHGDN |
Venous Thromboembolism | 0.007458414 | 2 | 0 | GAD_LHGDN |
Systemic arterial pressure | 0.007101096 | 3 | 0 | GAD |
Arteriosclerosis | 0.00706742 | 17 | 0 | BeFree_LHGDN |
Squamous cell carcinoma | 0.005991584 | 3 | 0 | BeFree_LHGDN |
Restenosis | 0.005819831 | 5 | 0 | BeFree_GAD |
Bullous pemphigoid | 0.005720142 | 2 | 0 | BeFree_LHGDN |
Age related macular degeneration | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
Stomach Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Mammary Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Celiac Disease | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Erythema Nodosum | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
Diabetic Retinopathy | 0.005091382 | 2 | 0 | GAD_LHGDN |
Premature Obstetric Labor | 0.005091382 | 2 | 0 | GAD_LHGDN |
Pre-Eclampsia | 0.005091382 | 2 | 0 | GAD_LHGDN |
Pseudoxanthoma Elasticum | 0.005091382 | 1 | 0 | GAD_LHGDN |
Thrombosis | 0.004734064 | 2 | 0 | GAD |
Diabetes Mellitus | 0.00408156 | 5 | 0 | BeFree_LHGDN |
Ischemia | 0.00408156 | 6 | 0 | BeFree_LHGDN |
Ischemic stroke | 0.003995683 | 7 | 0 | BeFree_GAD |
Colon Carcinoma | 0.003800186 | 14 | 0 | BeFree |
Liver carcinoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Asthma | 0.003181358 | 3 | 0 | BeFree_GAD |
Anemia, Sickle Cell | 0.002909916 | 3 | 0 | BeFree_GAD |
Graves Disease | 0.002909916 | 2 | 1 | BeFree_GAD |
Malaria | 0.002909916 | 2 | 0 | BeFree_GAD |
Periodontitis | 0.002909916 | 2 | 0 | BeFree_GAD |
Metabolic Syndrome X | 0.002909916 | 3 | 0 | BeFree_GAD |
Hepatitis B, Chronic | 0.002909916 | 2 | 0 | BeFree_GAD |
Acute Coronary Syndrome | 0.002909916 | 3 | 1 | BeFree_GAD |
Fabry Disease | 0.00272435 | 1 | 0 | LHGDN |
Biliary Atresia | 0.00272435 | 1 | 0 | LHGDN |
Carotid Artery Diseases | 0.00272435 | 1 | 0 | LHGDN |
Cluster Headache | 0.00272435 | 1 | 0 | LHGDN |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Duodenal Ulcer | 0.00272435 | 1 | 0 | LHGDN |
Gastritis | 0.00272435 | 1 | 0 | LHGDN |
Leukemia, Myelocytic, Acute | 0.00272435 | 1 | 0 | LHGDN |
Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Lupus Nephritis | 0.00272435 | 1 | 0 | LHGDN |
Lymphoma, Non-Hodgkin | 0.00272435 | 1 | 0 | LHGDN |
Pancreatitis | 0.00272435 | 1 | 0 | LHGDN |
Giant Cell Arteritis | 0.00272435 | 1 | 0 | LHGDN |
Thromboangiitis Obliterans | 0.00272435 | 1 | 0 | LHGDN |
Impaired glucose tolerance | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Adenocarcinoma | 0.002638474 | 2 | 0 | BeFree_GAD |
Inflammatory Bowel Diseases | 0.002638474 | 2 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.002367032 | 1 | 0 | GAD |
Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 0 | GAD |
Arterial Occlusive Diseases | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Cerebral Palsy | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular Disorders | 0.002367032 | 1 | 0 | GAD |
Chlamydia Infections | 0.002367032 | 1 | 0 | GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Dental Plaque | 0.002367032 | 1 | 0 | GAD |
Diabetic Nephropathy | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Gingival Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Insulin Resistance | 0.002367032 | 1 | 0 | GAD |
Lupus Vulgaris | 0.002367032 | 1 | 0 | GAD |
Lupus Erythematosus, Discoid | 0.002367032 | 1 | 0 | GAD |
Osteoporosis | 0.002367032 | 1 | 0 | GAD |
Pancreatic Neoplasm | 0.002367032 | 1 | 0 | GAD |
Periodontal Pocket | 0.002367032 | 1 | 0 | GAD |
Periodontitis, Juvenile | 0.002367032 | 1 | 0 | GAD |
Q Fever | 0.002367032 | 1 | 0 | GAD |
Schizophrenia | 0.002367032 | 1 | 0 | GAD |
Trachoma | 0.002367032 | 1 | 0 | GAD |
Venous Thrombosis | 0.002367032 | 1 | 0 | GAD |
Diffuse Large B-Cell Lymphoma | 0.002367032 | 1 | 0 | GAD |
Peripheral Vascular Diseases | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Periodontal Attachment Loss | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of lung | 0.002367032 | 1 | 0 | GAD |
Chronic Periodontitis | 0.002367032 | 1 | 0 | GAD |
Complications of Diabetes Mellitus | 0.002367032 | 1 | 0 | GAD |
Lupus Erythematosus | 0.002367032 | 1 | 0 | GAD |
Blood pressure finding | 0.002367032 | 1 | 0 | GAD |
Peripheral Arterial Diseases | 0.002367032 | 1 | 0 | GAD |
Coronary artery disease, premature | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.002171535 | 8 | 0 | BeFree |
Malignant tumor of colon | 0.002171535 | 8 | 0 | BeFree |
Breast Carcinoma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001900093 | 7 | 2 | BeFree |
Stomach Carcinoma | 0.001900093 | 7 | 2 | BeFree |
Colorectal Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.001628651 | 6 | 0 | BeFree |
melanoma | 0.001085767 | 4 | 0 | BeFree |
Diabetes | 0.000814326 | 3 | 0 | BeFree |
Systemic Scleroderma | 0.000814326 | 3 | 0 | BeFree |
Pancreatic carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Chronic kidney disease stage 5 | 0.000814326 | 3 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Vascular Diseases | 0.000542884 | 2 | 0 | BeFree |
Chronic sinusitis | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Vasculitis of the skin | 0.000542884 | 2 | 0 | BeFree |
Inflammatory Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
Carotid Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Endothelial dysfunction | 0.000542884 | 2 | 0 | BeFree |
Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Anthracosis | 0.000271442 | 1 | 0 | BeFree |
Bronchiolitis Obliterans | 0.000271442 | 1 | 0 | BeFree |
Brucellosis | 0.000271442 | 1 | 0 | BeFree |
Merkel cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mucinous Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Colitis | 0.000271442 | 1 | 0 | BeFree |
Dengue Fever | 0.000271442 | 1 | 0 | BeFree |
Eczema | 0.000271442 | 1 | 0 | BeFree |
Bacterial Endocarditis | 0.000271442 | 1 | 0 | BeFree |
Fatty Liver | 0.000271442 | 1 | 0 | BeFree |
Gingivitis | 0.000271442 | 1 | 0 | BeFree |
Cardiac Arrest | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
Hypercholesterolemia, Familial | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Intestinal Perforation | 0.000271442 | 1 | 2 | BeFree |
Kidney Failure, Acute | 0.000271442 | 1 | 0 | BeFree |
Leg Ulcer | 0.000271442 | 1 | 0 | BeFree |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Leukopenia | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
Liver diseases | 0.000271442 | 1 | 0 | BeFree |
Alcoholic Liver Diseases | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Malaria, Cerebral | 0.000271442 | 1 | 0 | BeFree |
Malaria, Falciparum | 0.000271442 | 1 | 0 | BeFree |
Mycoses | 0.000271442 | 1 | 0 | BeFree |
Neutropenia | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Pustulosis of Palms and Soles | 0.000271442 | 1 | 0 | BeFree |
Peritonitis | 0.000271442 | 1 | 0 | BeFree |
Phlebitis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Kidney Failure | 0.000271442 | 1 | 0 | BeFree |
Respiratory Distress Syndrome, Adult | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Nodule | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Shwartzman Phenomenon | 0.000271442 | 1 | 0 | BeFree |
Thrombocythemia, Essential | 0.000271442 | 1 | 0 | BeFree |
Thromboembolism | 0.000271442 | 1 | 0 | BeFree |
Varicosity | 0.000271442 | 1 | 0 | BeFree |
von Willebrand Disease | 0.000271442 | 1 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Retinal Vasculitis | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
Disease of capillaries | 0.000271442 | 1 | 0 | BeFree |
Lichen Planus, Oral | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Drug usage | 0.000271442 | 1 | 0 | BeFree |
Systemic Inflammatory Response Syndrome | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of colon stage IV | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of colon | 0.000271442 | 1 | 0 | BeFree |
Diabetic maculopathy | 0.000271442 | 1 | 0 | BeFree |
Internal Carotid Artery Stenosis | 0.000271442 | 1 | 0 | BeFree |
Dissection of aorta | 0.000271442 | 1 | 0 | BeFree |
Erythema nodosum leprosum | 0.000271442 | 1 | 0 | BeFree |
Overweight | 0.000271442 | 1 | 0 | BeFree |
Recurrent tumor | 0.000271442 | 1 | 2 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
Disorder of macula of retina | 0.000271442 | 1 | 0 | BeFree |
Renal ischaemia | 0.000271442 | 1 | 0 | BeFree |
Inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
Chronic inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Chronic venous insufficiency | 0.000271442 | 1 | 0 | BeFree |
Myocardial necrosis | 0.000271442 | 1 | 0 | BeFree |
Breast Cancer Model | 0.000271442 | 1 | 0 | BeFree |
Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
Tumor-Associated Vasculature | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Infective endocarditis | 0.000271442 | 1 | 0 | BeFree |
tumor vasculature | 0.000271442 | 1 | 0 | BeFree |
Prehypertension | 0.000271442 | 1 | 0 | BeFree |
Recurrent infections (sinusitis and bacterial pneumonia and meningitis) | 0.000271442 | 1 | 0 | BeFree |
Juvenile arthritis | 0.000271442 | 1 | 0 | BeFree |
Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
Juvenile rheumatoid arthritis | 0.000271442 | 1 | 0 | BeFree |
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