EPOR(erythropoietin receptor)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19p13.3-p13.2
基因染色体位置图

基因简述

基因简述

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

[中文简述(自动翻译):]  该基因编码促红细胞生成素受体是细胞因子受体家族的一个成员。经促红细胞生成素的结合，这种受体激活从而激活细胞内的不同途径，包括Jak2的酪氨酸激酶：RAS / MAP激酶，磷酸肌醇3-激酶和STAT转录因子。受激促红细胞生成素受体似乎在红细胞细胞存活的作用。在红细胞生成素受体缺陷可能产生白血病和家族性红细胞增多症。该基因的调节异常可能会影响某些肿瘤的生长。选择性剪接结果在多个抄本变形。[由RefSeq的，2010年5月提供]

OMIM数据库中对EPOR基因的介绍     Wikipedia数据库中对EPOR基因的介绍

基因序列

基因序列

EPOR基因的碱基序列：[NCBI]

基因突变

基因突变

EPOR基因的碱基突变：           显示全部snp
rs316500       rs317927       rs318717       rs318718       rs318719       rs3216772       rs4804162       rs4804163       rs35423344       rs35586415       rs35977803       rs45516306       rs55966307       rs60825798       rs61729384       rs61729445       rs62131142       rs62131143       rs62638744       rs62638745       rs71164194       rs71164195       rs72992936       rs73922650       rs74179989       rs76045684       rs77080457       rs77899871       rs78532283       rs80181949       rs111263420       rs111341143       rs111612809       rs112004805       rs112348054       rs112371899       rs112493159      
rs112978768       rs113239777       rs113780625       rs114157218       rs114645751       rs115946094       rs116917543       rs117580409       rs121917831       rs138005400       rs138190746       rs138449488       rs138559043       rs138710419       rs138884102       rs138981656       rs139323909       rs139409529       rs139654323       rs139756642       rs139849355       rs140186158       rs140267472       rs140441486       rs140630699       rs140903357       rs140940687       rs141096553       rs141262829       rs141524122       rs141940285       rs142094773       rs142190113       rs142544914       rs142688979       rs142951311       rs143402071       rs144250010       rs145098182       rs145717443       rs146235694       rs146315075       rs146537963       rs146578258       rs146937816       rs147096924       rs147119630       rs147359717       rs147573962       rs148340466       rs148651650       rs149193129       rs149300172       rs149714073       rs149831382       rs149947827       rs150535617       rs150695961       rs151226066       rs180975926       rs181052905       rs181397031       rs181819570       rs182846484       rs182850257       rs183080185       rs183679845       rs184452209       rs184589099       rs184593626       rs185249501       rs185393385       rs185740642       rs185885179       rs185984864       rs186506713       rs186567827       rs187931104       rs188092731       rs188960747       rs188981437       rs189654731       rs189813612       rs190590369       rs190989303       rs191025147       rs191396908       rs191481987       rs191728910       rs192441411       rs192491093       rs192525298       rs192923196       rs192996229       rs199509853       rs199637505       rs199645071       rs199653196       rs199784763       rs199788179       rs200057444       rs200372382       rs200443956       rs200458897       rs200533918       rs200636512       rs200749660       rs200974642       rs200991498       rs200997864       rs201075113       rs201253733       rs201571204       rs201869724       rs201953069       rs202041743       rs202198017       rs281860298       rs367583626       rs367619908       rs367994954       rs368098451       rs368363386       rs369085901       rs369228469       rs369251866       rs369327794       rs369880281       rs370023439       rs370515840       rs370541202       rs370841243       rs370865377       rs371029194       rs371578227       rs371786811       rs371950695       rs371996814       rs373277892       rs373647199       rs373709817       rs373802520       rs373833534       rs374025764       rs374188164       rs374237735       rs374275340       rs374871864       rs375609414       rs375735369       rs375796660       rs377285358       rs377322757       rs377550572       rs377609533       rs377657947       rs398039171       rs528356712       rs528560276       rs529274255       rs529417277       rs529457521       rs529662967       rs530287783       rs530472327       rs530717584       rs530876130       rs530996065       rs531117331       rs531190786       rs531963036       rs533014098       rs533141447       rs533281275       rs533306013       rs533338530       rs533755786       rs534420842       rs534469208       rs534494223       rs534514832       rs534606974       rs534700156       rs535046868       rs535127351       rs535171409       rs535427979       rs536126766       rs536321990       rs537042106       rs537555623       rs538164797       rs538946266       rs539165327       rs539406596       rs540622146       rs540661889       rs540865349       rs540939081       rs541493600       rs542452128       rs542526917       rs542643797       rs542954029       rs543205092       rs543241251       rs543518223       rs543828870       rs544508616       rs544550329       rs545113608       rs545331673       rs545506502       rs546336567       rs546347507       rs546372293       rs546490013       rs546510851       rs546531932       rs547061237       rs547246773       rs548327293       rs548445028       rs548448212       rs548794299       rs548826797       rs550540904       rs550655753       rs550706752       rs551381138       rs551524426       rs551636869       rs551912748       rs552076325       rs552661632       rs552682487       rs552777813       rs552795592       rs552844261       rs553016457       rs553452571       rs553981043       rs554091140       rs554358189       rs554750793       rs554917526       rs555443205       rs556685864       rs557748676       rs557770397       rs558353698       rs558379957       rs558887457       rs558924254       rs558928134       rs559611101       rs559660844       rs560262920       rs560392821       rs561636122       rs562204600       rs562625915       rs562676037       rs562713613       rs562749732       rs562985381       rs563298152       rs563854712       rs564492468       rs564514735       rs564676813       rs565787784       rs565950978       rs566492472       rs566601370       rs567166322       rs567946217       rs568041131       rs568100674       rs568455741       rs569043534       rs569851700       rs569886816       rs570168670       rs570329639       rs570411222       rs571309242       rs572245157       rs572409030       rs573450482       rs573533901       rs573617326       rs573841655       rs574147693       rs574200340       rs574397044       rs574619833       rs574992566       rs575967230       rs576011390       rs576181733       rs576210538       rs576573303       rs576644426       rs577368929       rs578029760       rs745435189       rs745543338       rs745615457       rs745809568       rs745829572       rs746019569       rs746110220       rs746110354       rs746192579       rs746306017       rs746309418       rs746562498       rs746688530       rs746771835       rs746870545       rs746928121       rs747143790       rs747212364       rs747347964       rs747467034       rs747516758       rs747539873       rs747618605       rs747661837       rs747796857       rs747816108       rs747944873       rs748035060       rs748120978       rs748156529       rs748324034       rs748327469       rs748484141       rs748486297       rs748682367       rs748825806       rs748929970       rs749060498       rs749153526       rs749359177       rs749444912       rs749474213       rs749724218       rs749770621       rs749855912       rs749908751       rs750105249       rs750107289       rs750281659       rs750295289       rs750556052       rs750630121       rs750657898       rs750673369       rs750747858       rs750797567       rs750931574       rs751064183       rs751128212       rs751254435       rs751352150       rs751412892       rs751506215       rs751621912       rs751644570       rs751866420       rs751952585       rs751983335       rs752030854       rs752058983       rs752284960       rs752306228       rs752527298       rs752677341       rs752767341       rs752970472       rs753197605       rs753346468       rs753446089       rs753744340       rs753901743       rs753903452       rs753983115       rs754113972       rs754116067       rs754190606       rs754199429       rs754602316       rs754612403       rs754708788       rs754814646       rs754854843       rs755011168       rs755076105       rs755199795       rs755390366       rs755572218       rs755986351       rs756074310       rs756134980       rs756205858       rs756310587       rs756329208       rs756352816       rs756423201       rs756442349       rs756575984       rs756598638       rs756623330       rs756706572       rs756727018       rs756971485       rs757072422       rs757329990       rs757333864       rs757449517       rs757492329       rs757511012       rs757686942       rs757732815       rs757740494       rs757749225       rs757826226       rs758069237       rs758104665       rs758156767       rs758222628       rs758272993       rs758465676       rs758630505       rs758637054       rs758694779       rs759093549       rs759181310       rs759502326       rs759629676       rs759686842       rs759826375       rs759896829       rs759920612       rs760060693       rs760118478       rs760176737       rs760294447       rs760437132       rs760526845       rs760561093       rs760571532       rs760602909       rs760820356       rs760933986       rs761020369       rs761066937       rs761106522       rs761263193       rs761347229       rs761397494       rs761682694       rs761747539       rs761965367       rs762053489       rs762055342       rs762067686       rs762127631       rs762427207       rs762531459       rs762641233       rs762813124       rs763281798       rs763485317       rs763511227       rs763533921       rs763588558       rs763619208       rs763766126       rs763877221       rs764073509       rs764148310       rs764244373       rs764385147       rs764395602       rs764402584       rs764553795       rs764671462       rs764896894       rs764963240       rs765009836       rs765048222       rs765049461       rs765269651       rs765348514       rs765416476       rs765467666       rs765522005       rs765615096       rs765796604       rs766177850       rs766194739       rs766209987       rs766374051       rs766378891       rs766471919       rs766559005       rs766735918       rs766844526       rs766858094       rs766932379       rs767166590       rs767335554       rs767356681       rs767592247       rs767650943       rs767702352       rs767798700       rs767964675       rs768035763       rs768211482       rs768244603       rs768450038       rs768508781       rs768583342       rs768605894       rs768821794       rs768868654       rs768908131       rs769140416       rs769244493       rs769284924       rs769474840       rs769476347       rs769484228       rs769709218       rs769735195       rs769772356       rs770000988       rs770002611       rs770113276       rs770377268       rs770437909       rs770519263       rs770575937       rs770608744       rs770845339       rs771039244       rs771039560       rs771105576       rs771124995       rs771197602       rs771235530       rs771294122       rs771335409       rs771507239       rs771615437       rs771666923       rs771710255       rs771819533       rs771864054       rs771984044       rs771993916       rs772172210       rs772238101       rs772383554       rs772424219       rs772690195       rs772835927       rs772993810       rs773011773       rs773038974       rs773271061       rs773302499       rs773372608       rs773520013       rs773564773       rs773772836       rs774045284       rs774087666       rs774094479       rs774151596       rs774177824       rs774307582       rs774415917       rs774430628       rs774431553       rs774731003       rs774803580       rs774921687       rs775003412       rs775164142       rs775200018       rs775215856       rs775290741       rs775300179       rs775673814       rs775673989       rs775746449       rs775757499       rs776028767       rs776054067       rs776055278       rs776060672       rs776131622       rs776257341       rs776340905       rs776430873       rs776446483       rs776503090       rs776698147       rs776798283       rs776800957       rs776887278       rs777198652       rs777274774       rs777458672       rs777726345       rs777739386       rs777923129       rs778121683       rs778130581       rs778198044       rs778302859       rs778403971       rs778413981       rs778494949       rs778502413       rs778504065       rs778551793       rs778780691       rs778870915       rs778896780       rs778903865       rs778995825       rs779242842       rs779264719       rs779330970       rs779538586       rs779543346       rs779647523       rs779926236       rs780010936       rs780044930       rs780132674       rs780132743       rs780211136       rs780511755       rs780594150       rs780617943       rs780705663       rs780814073       rs781154864       rs781223562       rs781454885       rs781554878       rs781710022       rs781761386       rs781767051      

基因表达

基因表达

EPOR基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTACCAGCTCGAGGATGAG
59
TTGATGTGGATGACACGGT
59
AGGGTAACTTCCAGCTGTG
59
GCTCTGAGAGGACTTCCAG
59
AGGGTAACTTCCAGCTGTG
59
GCTCTGAGAGGACTTCCAG
59
ATGAAGTAGTGCTCCTAGACG
59
GAGACGTCATGGGTGTCTC
59
AGGGTAACTTCCAGCTGTG
59
GCTCTGAGAGGACTTCCAG
59
CTCATCCTCGTGGTCATCC
60
CAGATCTTCTGCTTCAGAGC
59
CTACCAGCTCGAGGATGAG
59
TGGATGACACGGTGATATCG
60
CTACCAGCTCGAGGATGAG
59
TGGATGACACGGTGATATCG
60
GAGACACCCATGACGTCTC
60
GATCTCCACCCTCTGTACG
59
GATATCACCGTGTCATCCAC
58
GATCTCCACCCTCTGTACG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

EPOR基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

EPOR基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004888
K7EN47(UniProtKB)
IEA
GO:0007165
K7EN47(UniProtKB)
IEA
GO:0016021
K7EN47(UniProtKB)
IEA
GO:0004888
K7EP50(UniProtKB)
IEA
GO:0007165
K7EP50(UniProtKB)
IEA
GO:0016021
K7EP50(UniProtKB)
IEA
GO:0004888
K7ERB5(UniProtKB)
IEA
GO:0007165
K7ERB5(UniProtKB)
IEA
GO:0016021
K7ERB5(UniProtKB)
IEA
GO:0004900
P19235(UniProtKB)
IDA
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005515
P19235(UniProtKB)
IPI
GO:0005576
P19235(UniProtKB)
IEA
GO:0005829
P19235(UniProtKB)
IEA
GO:0005887
P19235(UniProtKB)
TAS
GO:0007165
P19235(UniProtKB)
NAS
GO:0007204
P19235(UniProtKB)
IEA
GO:0007420
P19235(UniProtKB)
IEA
GO:0007507
P19235(UniProtKB)
IEA
GO:0008284
P19235(UniProtKB)
IEA
GO:0009897
P19235(UniProtKB)
IEA
GO:0010976
P19235(UniProtKB)
IEA
GO:0038162
P19235(UniProtKB)
IEA
GO:0042802
P19235(UniProtKB)
IPI
GO:0043524
P19235(UniProtKB)
IEA
GO:0046697
P19235(UniProtKB)
IEA
GO:0070374
P19235(UniProtKB)
IEA
GO:1903206
P19235(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控EPOR基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Familial erythrocytosis 0.445352893 13 2 BeFree_CTD_human_GAD_MGD_ORPHANET_UNIPROT
Polycythemia 0.130877538 22 1 BeFree_CTD_human_LHGDN
Mammary Neoplasms 0.125720142 4 0 BeFree_CTD_human_LHGDN
Acute Erythroblastic Leukemia 0.124895885 9 1 BeFree_CLINVAR_LHGDN
Neoplasm Metastasis 0.12272435 2 0 CTD_human_LHGDN
Thyroid Neoplasm 0.12272435 1 0 CTD_human_LHGDN
melanoma 0.121085767 4 0 BeFree_CTD_human
Neoplasm Invasiveness 0.12 1 0 CTD_human
Nerve Degeneration 0.12 1 0 CTD_human
Glioma 0.080542884 2 0 BeFree_RGD
Cholangiocarcinoma 0.080271442 1 0 BeFree_RGD
Fetal Distress 0.08 1 0 RGD
Hepatic Encephalopathy 0.08 1 0 RGD
Myocardial Infarction 0.08 1 0 RGD
Brain Hypoxia 0.08 2 0 RGD
leukemia 0.006534468 5 0 BeFree_LHGDN
Myeloproliferative disease 0.005362824 3 0 BeFree_GAD_LHGDN
MYELODYSPLASTIC SYNDROME 0.005091382 2 0 GAD_LHGDN
Polycythemia Vera 0.004810009 9 6 BeFree_GAD
Renal Cell Carcinoma 0.003810118 5 0 BeFree_LHGDN
Squamous cell carcinoma 0.002995792 2 0 BeFree_LHGDN
Pheochromocytoma 0.002995792 2 0 BeFree_LHGDN
Alzheimer's Disease 0.00272435 1 0 LHGDN
Anoxia 0.00272435 1 0 LHGDN
Cyst 0.00272435 1 0 LHGDN
Endometrial Neoplasms 0.00272435 1 0 LHGDN
Endometriosis 0.00272435 1 0 LHGDN
Head and Neck Neoplasms 0.00272435 1 0 LHGDN
Hyperplasia 0.00272435 1 0 LHGDN
Mesothelioma 0.00272435 1 0 LHGDN
Parathyroid Neoplasms 0.00272435 1 0 LHGDN
Prostatic Neoplasms 0.00272435 1 0 LHGDN
ovarian neoplasm 0.00272435 1 0 LHGDN
Thrombocythemia, Essential 0.002638474 1 4 BeFree_GAD
Lymphoproliferative Disorders 0.002367032 1 0 GAD
Erythrocytosis 0.002171535 8 0 BeFree
Malignant neoplasm of breast 0.001357209 5 0 BeFree
Tumor Progression 0.001357209 5 0 BeFree
Breast Carcinoma 0.001357209 5 0 BeFree
Non-Small Cell Lung Carcinoma 0.001085767 4 0 BeFree
Prostate carcinoma 0.001085767 4 0 BeFree
Malignant neoplasm of prostate 0.000814326 3 0 BeFree
Brain Neoplasms 0.000542884 2 0 BeFree
Kidney Failure, Chronic 0.000542884 2 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000542884 2 0 BeFree
Precursor B-cell lymphoblastic leukemia 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Primary Myelofibrosis 0.000271442 1 4 BeFree
Anemia 0.000271442 1 0 BeFree
Cardiovascular Diseases 0.000271442 1 0 BeFree
Ependymoma 0.000271442 1 0 BeFree
Von Hippel-Lindau Syndrome 0.000271442 1 0 BeFree
Hypertensive disease 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Acute lymphocytic leukemia 0.000271442 1 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.000271442 1 0 BeFree
Medulloblastoma 0.000271442 1 0 BeFree
Monoclonal Gammopathy of Undetermined Significance 0.000271442 1 0 BeFree
Multiple Myeloma 0.000271442 1 0 BeFree
Neuroblastoma 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Precancerous Conditions 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Hepatoblastoma 0.000271442 1 0 BeFree
Female Pseudohermaphroditism 0.000271442 1 0 BeFree
Anemia, severe 0.000271442 1 0 BeFree
Chronic myocardial ischemia 0.000271442 1 0 BeFree
Simple renal cyst 0.000271442 1 0 BeFree
Malignant mesothelioma 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Leukemogenesis 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Central neuroblastoma 0.000271442 1 0 BeFree
Malignant neoplasm of kidney 0.000271442 1 0 BeFree
Cardiac defects 0.000271442 1 0 BeFree
High-Grade Prostatic Intraepithelial Neoplasia 0.000271442 1 0 BeFree
Renal carcinoma 0.000271442 1 0 BeFree
tumor vasculature 0.000271442 1 0 BeFree
Parvovirus B19 (disease) 0.000271442 1 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000271442 1 0 BeFree
Prostatic Hyperplasia 0.000271442 1 0 BeFree
Anemia in malignant neoplastic disease 0.000271442 1 0 BeFree

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