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This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]
[中文简述(自动翻译):]  该基因,趋化因子(C-C基序)配体14,是聚集在17q11.2几个CC细胞因子基因之一。在CC细胞因子分泌特征在于两个相邻的半胱氨酸的蛋白质。由该基因编码的细胞因子诱导的细胞内钙离子浓度和单核细胞中酶的释放的变化。已发现该基因编码不同亚型的多个抄本变形。通读成绩单也表示,包括从上游细胞因子基因,趋化因子(C-C基序)配体15个外显子,并表示为GeneID:348249. [由提供RefSeq的,2009年12月]
CCL14基因(以及对应的蛋白质)的细胞分布位置:
CCL14基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Lupus Erythematosus, Systemic | 0.002638474 | 1 | 0 | BeFree_GAD |
Asthma | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Multiple Sclerosis | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Liver carcinoma | 0.001085767 | 4 | 0 | BeFree |
Liver Cirrhosis | 0.000814326 | 3 | 0 | BeFree |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
Cirrhosis | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Kidney Failure, Chronic | 0.000271442 | 1 | 0 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
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