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This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
[中文简述(自动翻译):]  该基因产物属于14-3-3家族,通过结合含有磷酸丝氨酸蛋白介导的信号转导的蛋白质。此高度保守的蛋白家族在植物和哺乳动物中发现,而该蛋白质是99%相同的小鼠,大鼠和绵羊直向同源物。所编码的蛋白质与IRS1蛋白相互作用,这表明在调节胰岛素敏感性的作用。在5‘端非编码区不同,但编码相同的蛋白的几个转录变体已被确定为这个基因。 [由RefSeq的,2008年10月提供]
YWHAZ基因(以及对应的蛋白质)的细胞分布位置:
YWHAZ基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Animal Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
Neoplasm Recurrence, Local | 0.12 | 1 | 0 | CTD_human |
Dehydration | 0.08 | 1 | 0 | RGD |
Absence Epilepsy | 0.08 | 1 | 0 | RGD |
Hypertensive disease | 0.08 | 1 | 0 | RGD |
Seizures | 0.08 | 1 | 0 | RGD |
Alzheimer's Disease | 0.005634266 | 4 | 0 | BeFree_GAD_LHGDN |
Atherosclerosis | 0.004624443 | 8 | 0 | BeFree_LHGDN |
Schizophrenia | 0.004624443 | 8 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.003800186 | 14 | 0 | BeFree |
Breast Carcinoma | 0.003800186 | 14 | 0 | BeFree |
Neurodegenerative Disorders | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Paranoid Schizophrenia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Parkinson Disease | 0.00272435 | 1 | 0 | LHGDN |
Autistic Disorder | 0.002638474 | 2 | 0 | BeFree_GAD |
Prostate carcinoma | 0.002442977 | 9 | 0 | BeFree |
Liver carcinoma | 0.002442977 | 9 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 1 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Membranous glomerulonephritis | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of prostate | 0.002171535 | 8 | 0 | BeFree |
Arteriosclerosis | 0.001900093 | 7 | 0 | BeFree |
Idiopathic Membranous Glomerulonephritis | 0.001900093 | 7 | 0 | BeFree |
Infantile Neuroaxonal Dystrophy | 0.001900093 | 7 | 0 | BeFree |
Carcinogenesis | 0.001900093 | 7 | 0 | BeFree |
Neoplasm Metastasis | 0.001628651 | 6 | 0 | BeFree |
Colorectal Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Liver neoplasms | 0.001357209 | 5 | 0 | BeFree |
Neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of lung | 0.001357209 | 5 | 0 | BeFree |
Carcinoma of lung | 0.001357209 | 5 | 0 | BeFree |
Squamous cell carcinoma | 0.001085767 | 4 | 0 | BeFree |
Coronary Arteriosclerosis | 0.001085767 | 4 | 0 | BeFree |
Coronary heart disease | 0.001085767 | 4 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.001085767 | 4 | 0 | BeFree |
Central neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Colorectal Cancer | 0.001085767 | 4 | 0 | BeFree |
Neurodegeneration with brain iron accumulation (NBIA) | 0.001085767 | 4 | 0 | BeFree |
Hallervorden-Spatz Syndrome | 0.000814326 | 3 | 0 | BeFree |
Isovaleryl-CoA dehydrogenase deficiency | 0.000814326 | 3 | 0 | BeFree |
Epithelial ovarian cancer | 0.000814326 | 3 | 0 | BeFree |
Mammary Neoplasms | 0.000814326 | 3 | 0 | BeFree |
Adenoma | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
Colitis | 0.000542884 | 2 | 0 | BeFree |
Colonic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Crohn Disease | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
Escherichia coli Infections | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Neurofibrillary degeneration (morphologic abnormality) | 0.000542884 | 2 | 0 | BeFree |
Mood Disorders | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
Non-Malignant Ascites Adverse Event | 0.000542884 | 2 | 0 | BeFree |
Anthrax disease | 0.000271442 | 1 | 0 | BeFree |
Arthritis | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Breast Diseases | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Cerebellar Ataxia | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Cystitis | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Esophagitis | 0.000271442 | 1 | 0 | BeFree |
Hay fever | 0.000271442 | 1 | 0 | BeFree |
Hemangioendothelioma | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Ileitis | 0.000271442 | 1 | 0 | BeFree |
Intestinal Polyps | 0.000271442 | 1 | 0 | BeFree |
Kidney Failure, Chronic | 0.000271442 | 1 | 0 | BeFree |
Leukodystrophy | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
Lymphatic Metastasis | 0.000271442 | 1 | 0 | BeFree |
Monoclonal Gammopathy of Undetermined Significance | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
Nasal Polyps | 0.000271442 | 1 | 0 | BeFree |
nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Polycystic Ovary Syndrome | 0.000271442 | 1 | 0 | BeFree |
polyps | 0.000271442 | 1 | 0 | BeFree |
Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Respiratory Distress Syndrome, Adult | 0.000271442 | 1 | 0 | BeFree |
Tuberous Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Chronic sinusitis | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of peritoneum | 0.000271442 | 1 | 0 | BeFree |
Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Myxoma of the Endocardium | 0.000271442 | 1 | 0 | BeFree |
Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
Disease due to Parvoviridae | 0.000271442 | 1 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
stage, ovarian epithelial cancer | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of colon | 0.000271442 | 1 | 0 | BeFree |
Fish-Eye Disease | 0.000271442 | 1 | 0 | BeFree |
Intrahepatic Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Chemical Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
invasive cancer | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Lymphangioleiomyomatosis | 0.000271442 | 1 | 0 | BeFree |
Cholesterol gallstones | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Allergic bronchitis | 0.000271442 | 1 | 0 | BeFree |
Empty follicle syndrome | 0.000271442 | 1 | 0 | BeFree |
Atypical Ductal Breast Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Angiogenic Switch | 0.000271442 | 1 | 0 | BeFree |
Mammary Tumorigenesis | 0.000271442 | 1 | 0 | BeFree |
Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
FRAGILE X TREMOR/ATAXIA SYNDROME | 0.000271442 | 1 | 0 | BeFree |
Neuroferritinopathy | 0.000271442 | 1 | 0 | BeFree |
Polyposis Of Gastric Fundus Without Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
Parvovirus B19 (disease) | 0.000271442 | 1 | 0 | BeFree |
Chronic kidney disease stage 5 | 0.000271442 | 1 | 0 | BeFree |
FAMILIAL ADENOMATOUS POLYPOSIS, ATTENUATED (disorder) | 0.000271442 | 1 | 0 | BeFree |
Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
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