更多...
收起
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是喾异二聚体蛋白,其也被称为ATP依赖的DNA解旋酶II或DNA修复蛋白XRCC5的80千道尔顿亚单位。区是DNA依赖性蛋白激酶的DNA结合成分,并将其与在DNA双链断裂的通过非同源末端连接修复的DNA连接酶IV-XRCC4复杂和V的完成(D)的功能一起J重组事件。该基因功能的补充中国仓鼠XRS-6,在DNA双链断裂修复突变体缺陷并且在经过V(D)J重组的能力。在这个基因的罕见的微卫星多态性与癌症的放射敏感性不同的患者。 [由RefSeq的,2008年7月提供]
XRCC5基因(以及对应的蛋白质)的细胞分布位置:
XRCC5基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Malignant neoplasm of breast | 0.012920927 | 8 | 0 | BeFree_GAD |
| Malignant neoplasm of urinary bladder | 0.010282454 | 5 | 0 | BeFree_GAD |
| Malignant neoplasm of lung | 0.008186863 | 7 | 0 | BeFree_GAD |
| Multiple Myeloma | 0.006448592 | 5 | 0 | BeFree_GAD_LHGDN |
| Adenocarcinoma | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
| Squamous cell carcinoma | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
| Chronic Obstructive Airway Disease | 0.005276948 | 3 | 0 | BeFree_GAD |
| Head and Neck Neoplasms | 0.004734064 | 2 | 0 | GAD |
| melanoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
| Neuroectodermal Tumors | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Chronic Lymphocytic Leukemia | 0.002909916 | 3 | 0 | BeFree_GAD |
| Myeloid Leukemia | 0.002909916 | 3 | 0 | BeFree_GAD |
| Herpes Simplex Infections | 0.00272435 | 1 | 0 | LHGDN |
| Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Alcoholic Intoxication, Chronic | 0.002638474 | 2 | 0 | BeFree_GAD |
| Glioma | 0.002638474 | 2 | 0 | BeFree_GAD |
| Cancer of Head and Neck | 0.002638474 | 2 | 0 | BeFree_GAD |
| Colorectal Cancer | 0.002638474 | 1 | 0 | BeFree_GAD |
| Brain Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Deglutition Disorders | 0.002367032 | 1 | 0 | GAD |
| Meningioma | 0.002367032 | 1 | 0 | GAD |
| Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Multiple Sclerosis | 0.002367032 | 1 | 0 | GAD |
| Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
| Precancerous Conditions | 0.002367032 | 1 | 0 | GAD |
| Radiodermatitis | 0.002367032 | 1 | 0 | GAD |
| Thyroid Neoplasm | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of brain | 0.002367032 | 1 | 0 | GAD |
| Epithelial ovarian cancer | 0.002367032 | 1 | 0 | GAD |
| Non-Small Cell Lung Carcinoma | 0.001357209 | 5 | 6 | BeFree |
| Squamous cell carcinoma of esophagus | 0.001357209 | 5 | 1 | BeFree |
| Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
| Congenital chromosomal disease | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Ataxia Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
| Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
| Polycythemia Vera | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
| HIV Encephalopathy | 0.000271442 | 1 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| HIV encephalitis | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 2 | BeFree |
| Solid tumour | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 2 | BeFree |
| Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
| Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
| Tonsillar Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
| Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Parvovirus B19 (disease) | 0.000271442 | 1 | 0 | BeFree |
| aggressive cancer | 0.000271442 | 1 | 0 | BeFree |
| FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。