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Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
[中文简述(自动翻译):]  黄嘌呤脱氢酶属于组参与嘌呤的氧化代谢含钼羟化酶。所编码的蛋白质已被鉴定为是根据它来执行机制上不同功能能力的兼职蛋白。黄嘌呤脱氢酶可以通过可逆巯基氧化或通过不可逆的蛋白水解修饰被转换为黄嘌呤氧化酶。在黄嘌呤脱氢酶原因xanthinuria缺陷,可能有助于成人呼吸应激综合征,并且可以通过氧代谢依赖性机制使可能流感感染。 [由RefSeq的,2014年1月提供]
XDH基因(以及对应的蛋白质)的细胞分布位置:
XDH基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Xanthinuria, Type I | 0.482171535 | 8 | 2 | BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT |
Reperfusion Injury | 0.2 | 2 | 0 | CTD_human_RGD |
Ischemia | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Heart failure | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Autistic Disorder | 0.12 | 1 | 0 | CTD_human |
Heart Diseases | 0.12 | 1 | 0 | CTD_human |
Animal Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
Nerve Degeneration | 0.12 | 1 | 0 | CTD_human |
Pulmonary Embolism | 0.12 | 1 | 0 | CTD_human |
Thrombocytopenia | 0.12 | 1 | 0 | CTD_human |
Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
Major Depressive Disorder | 0.12 | 1 | 0 | CTD_human |
Hypertensive disease | 0.088358616 | 3 | 0 | BeFree_GAD_LHGDN_RGD |
Sepsis | 0.08272435 | 2 | 0 | LHGDN_RGD |
Pancreatitis | 0.080271442 | 2 | 0 | BeFree_RGD |
Diabetic Nephropathy | 0.08 | 1 | 0 | RGD |
Pneumoperitoneum | 0.08 | 1 | 0 | RGD |
Chronic Kidney Insufficiency | 0.08 | 1 | 0 | RGD |
Hyperuricemia | 0.08 | 1 | 0 | RGD |
Diabetic Cardiomyopathies | 0.08 | 1 | 0 | RGD |
Cardiomyopathies | 0.08 | 1 | 0 | RGD |
Liver carcinoma | 0.08 | 1 | 0 | RGD |
Acute kidney injury | 0.08 | 2 | 0 | RGD |
Anoxia | 0.0054487 | 2 | 0 | LHGDN |
Kidney Diseases | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
Inflammatory Bowel Diseases | 0.004734064 | 2 | 0 | GAD |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.004734064 | 2 | 0 | GAD |
Atherosclerosis | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Asthma | 0.00272435 | 1 | 0 | LHGDN |
Chronic Obstructive Airway Disease | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Sjogren's Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Meningioma | 0.002638474 | 2 | 2 | BeFree_GAD |
Brain Neoplasms | 0.002367032 | 1 | 0 | GAD |
Squamous cell carcinoma | 0.002367032 | 1 | 0 | GAD |
Carotid Artery Diseases | 0.002367032 | 1 | 0 | GAD |
Deafness | 0.002367032 | 1 | 0 | GAD |
Esophageal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Hearing Loss, Partial | 0.002367032 | 1 | 0 | GAD |
Liver Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Meningeal Neoplasms | 0.002367032 | 1 | 1 | GAD |
Occupational Diseases | 0.002367032 | 1 | 0 | GAD |
Hepatopulmonary Syndrome | 0.002367032 | 1 | 0 | GAD |
hearing impairment | 0.002367032 | 1 | 0 | GAD |
Hearing Loss | 0.002367032 | 1 | 0 | GAD |
Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
Xanthinuria | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Kidney Calculi | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Combined molybdoflavoprotein enzyme deficiency | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Endothelial dysfunction | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Nephrolithiasis | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Chronic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 1 | BeFree |
NEPHROLITHIASIS, CALCIUM OXALATE | 0.000271442 | 1 | 0 | BeFree |
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