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This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
[中文简述(自动翻译):]  该基因编码的Wiskott-Aldrich公司综合征蛋白家族的一个成员。的基因产物是形成多蛋白复合物,链接受体激酶和肌动蛋白的蛋白质。结合肌动蛋白发生通过在所有家庭成员的C-末端verprolin同源结构域。的多蛋白复合物的作用是tranduce涉及细胞形状,运动或功能的变化信号。发布的地图位置(PMID:10381382)已经改变根据最近的基因组序列比较,这表明,所表达的基因位于染色体1,和一个假基因可以在染色体X的位于两个转录变体编码不同同种型已被发现已这个基因。 [由RefSeq的,2011年1月提供]
WASF2基因(以及对应的蛋白质)的细胞分布位置:
WASF2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Neoplasm Metastasis | 0.00272435 | 1 | 0 | LHGDN |
Seizures | 0.00272435 | 1 | 0 | LHGDN |
Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
Antisocial behavior | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000542884 | 2 | 0 | BeFree |
Major Depressive Disorder | 0.000542884 | 2 | 0 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Eating Disorders | 0.000271442 | 1 | 0 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Depressive Symptoms | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Chlamydia trachomatis infection | 0.000271442 | 1 | 0 | BeFree |
Mild cognitive disorder | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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