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This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]
[中文简述(自动翻译):] 该基因编码的瓦宁蛋白家族中的一员,其彼此共享广泛的序列相似性,并与生物素酶。该家族包括分泌和膜相关的蛋白质,其中的一些已报道参与造血细胞的运输。无生物素活性已被证实为任何的瓦宁蛋白质,但是,它们具有pantetheinase活性,这可能在氧化应激反应的作用。这种蛋白质,像它的小鼠同源,可能是一个GPI锚定的细胞表面分子。鼠标蛋白是由血管周围胸腺基质细胞中表达,调节对胸腺T细胞的祖细胞的迁移。该基因位于靠近,并在同一转录方向为,在染色体6q23-Q24其他两个瓦宁基因。 [由RefSeq的,2009年2月提供]
VNN1基因(以及对应的蛋白质)的细胞分布位置:
VNN1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Inflammatory Bowel Diseases | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Psoriasis | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Dermatitis, Atopic | 0.12 | 1 | 0 | CTD_human |
Dyslipidemias | 0.12 | 1 | 0 | CTD_human |
Hypertensive disease | 0.005634266 | 2 | 1 | BeFree_GAD_LHGDN |
Malaria | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Osteoporosis | 0.002367032 | 1 | 0 | GAD |
Colitis | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Fanconi Syndrome | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 1 | BeFree |
Acute asthma | 0.000271442 | 1 | 0 | BeFree |
Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Nephropathic cystinosis | 0.000271442 | 1 | 0 | BeFree |
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