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Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  血管扩张剂刺激的磷蛋白(VASP)是埃纳-VASP蛋白家族的一个成员。 ENA-VASP家族成员包含结合含E / DFPPPPXD / E图案的蛋白质和目标ENA-VASP蛋白粘着斑的EHV1 N端结构域。在该蛋白的中间区域,家族成员有结合SH3和WW结构域的蛋白富含脯氨酸结构域。其C端EVH2域介导四聚,并结合双方G和F肌动蛋白。 VASP与丝状肌动蛋白的形成相关联,并且可能在细胞粘附和运动一个广泛的作用。 VASP也可以参与调节整联的细胞外基质相互作用的细胞内信号通路。 VASP是由循环依赖核苷酸激酶PKA和PKG调节。 [由RefSeq的,2008年7月提供]
VASP基因(以及对应的蛋白质)的细胞分布位置:
VASP基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Mammary Neoplasms | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Thrombosis | 0.0054487 | 2 | 0 | LHGDN |
Acute Coronary Syndrome | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Cardiovascular Diseases | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cardiomyopathy, Dilated | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Stomach Diseases | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Vascular inflammations | 0.000271442 | 1 | 0 | BeFree |
Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
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