UNG(uracil-DNA glycosylase)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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12q23-q24.1
基因染色体位置图

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

[中文简述(自动翻译):]  该基因编码塞弗之一拉尔尿嘧啶DNA糖基化酶。尿嘧啶DNA糖基化酶中的一个重要的功能是防止诱变由通过切割的N glycosylic键和启动碱基切除修复(BER)途径消除来自DNA分子尿嘧啶。尿嘧啶碱基胞嘧啶脱氨或者倾倒残错配发生。这个基因的替代性启动子的使用和剪接导致两种不同的同种型:线粒体UNG1和核UNG2。该UNG2术语被用作CCNO基因(GeneID 10309),它已被混淆该基因,在文献中和某些数据库前一符号。 [由RefSeq的,2010年11月提供]

UNG基因的碱基序列:[NCBI]
UNG基因的碱基突变:           显示全部snp
rs39655       rs246079       rs246080       rs2878959       rs3219268       rs3219269       rs3219270       rs3219271       rs3219272       rs3219273       rs3219275       rs12580935       rs35158079       rs41547115       rs55947010       rs56067042       rs56245907       rs58043104       rs71079524       rs77228664       rs112023422       rs113164038       rs139121065       rs139945727       rs140530578       rs142145673       rs142954123       rs143034537       rs143289779       rs144459888       rs145241612       rs145885690       rs147460908       rs149153434       rs149259073       rs150677845       rs183559652      
rs189054927       rs191416570       rs200129045       rs200602841       rs201922937       rs202127223       rs370657301       rs371905514       rs372577411       rs376465519       rs527515893       rs532806060       rs532894696       rs533948770       rs534297895       rs537943191       rs538270853       rs538993598       rs539650134       rs542862463       rs544581462       rs549176678       rs549239966       rs550287543       rs550595158       rs551612599       rs551666452       rs554204080       rs554736036       rs555851135       rs555912110       rs556280629       rs556576726       rs557668016       rs559851498       rs560472347       rs561414480       rs562354759       rs563230550       rs565480360       rs566676637       rs567725041       rs567806750       rs569425579       rs572384909       rs574164859       rs576554965       rs576935575       rs578171072       rs745495884       rs745539300       rs746676631       rs749691728       rs749817306       rs750553526       rs751857272       rs752015362       rs752695898       rs754286058       rs754968730       rs755239497       rs756699200       rs757819403       rs759670196       rs760528403       rs761656626       rs761842721       rs762008037       rs763969893       rs764190174       rs765063470       rs765151419       rs765415680       rs766408767       rs767818599       rs768307082       rs770547674       rs771426933       rs771826202       rs773114396       rs774041358       rs774834342       rs779142271       rs779264234       rs780475617       rs781332501       rs759561       rs11064754       rs246078       rs1018782       rs1018783       rs1018784       rs1368557       rs1610925       rs2268406       rs2337395       rs2430678       rs2515913       rs2541883       rs2541886       rs2569987       rs2857241       rs2857244       rs2857245       rs3021099       rs3219204       rs3219205       rs3219206       rs3219207       rs3219208       rs3219209       rs3219210       rs3219211       rs3219212       rs3219214       rs3219215       rs3219216       rs3219217       rs3219218       rs3219219       rs3219220       rs3219221       rs3219222       rs3219224       rs3219225       rs3219226       rs3219227       rs3219228       rs3219229       rs3219230       rs3219231       rs3219232       rs3219233       rs3219234       rs3219235       rs3219236       rs3219237       rs3219238       rs3219239       rs3219240       rs3219241       rs3219242       rs3219243       rs3219244       rs3219245       rs3219246       rs3219247       rs3219248       rs3219249       rs3219250       rs3219251       rs3219252       rs3219253       rs3219254       rs3219255       rs3219256       rs3219257       rs3219258       rs3219259       rs3219260       rs3219261       rs3219262       rs3219263       rs3219264       rs3219266       rs3219267       rs3782900       rs3847954       rs3890995       rs7488798       rs11832399       rs12317197       rs12816460       rs12817483       rs16939919       rs16939920       rs34833015       rs55740597       rs55802800       rs55812333       rs55993308       rs56106604       rs56146207       rs57894343       rs71443835       rs73413093       rs74956419       rs76091303       rs76391872       rs76465568       rs76827532       rs77035309       rs77914829       rs78963063       rs79129796       rs79457551       rs79744525       rs80001089       rs80230096       rs111400274       rs111664399       rs111881908       rs111922065       rs111970533       rs112130589       rs112361043       rs112643098       rs112836631       rs112986710       rs113097970       rs113359403       rs113426226       rs113481690       rs116921212       rs117065901       rs117999862       rs138123566       rs138514683       rs138725359       rs139040612       rs139169346       rs139694997       rs139867790       rs139936609       rs140065688       rs140241808       rs140243623       rs140273646       rs140301639       rs140649386       rs140676734       rs140756098       rs140829672       rs140859900       rs141518006       rs141783420       rs142097025       rs142184271       rs142993524       rs143103316       rs143280617       rs143527092       rs143941638       rs144025679       rs144083363       rs144108564       rs144209178       rs144650704       rs144659471       rs145296454       rs145545688       rs146351338       rs146400570       rs146408261       rs146420387       rs146457841       rs146515171       rs146685524       rs147057950       rs147467825       rs147490205       rs147530375       rs147607598       rs148037258       rs148650726       rs149038241       rs149197671       rs149673619       rs150033310       rs150115268       rs150180082       rs150646176       rs151095402       rs180819617       rs180866679       rs181840521       rs181898328       rs182240037       rs182850249       rs183151774       rs183290016       rs183557943       rs183626957       rs183828312       rs184143188       rs184404735       rs184938961       rs185695533       rs186494007       rs186828949       rs187049853       rs187427679       rs187858476       rs188001189       rs188007400       rs188013145       rs188688531       rs189263635       rs189795797       rs189886341       rs190331818       rs190671655       rs190815236       rs191332403       rs191439521       rs192483790       rs192581892       rs192807474       rs192947567       rs193148635       rs199547586       rs199956941       rs200073522       rs200273184       rs200337728       rs200492469       rs200572869       rs200609190       rs201031933       rs201146665       rs201388456       rs201420577       rs201555956       rs201623117       rs202212890       rs368013839       rs368190134       rs368693705       rs368747391       rs368919428       rs369360198       rs369677873       rs370117219       rs370772651       rs370788222       rs371482568       rs372022075       rs372914375       rs373087239       rs373142518       rs373518543       rs373668102       rs373915335       rs373929934       rs374999785       rs375138321       rs375200239       rs375712849       rs375942655       rs376013015       rs376170145       rs376181894       rs376264636       rs376873909       rs376918741       rs377075959       rs377203641       rs397825341       rs397840404       rs527248864       rs527285906       rs527980794       rs528503349       rs528596057       rs529009997       rs529264744       rs529272921       rs529437404       rs529576193       rs529610114       rs529870039       rs529984658       rs530678745       rs530828630       rs530889106       rs530949522       rs531358619       rs531673622       rs532224536       rs532289191       rs532615915       rs532866050       rs533318575       rs533842021       rs534028513       rs534071307       rs534355152       rs534356424       rs534647670       rs534710592       rs534934926       rs535034511       rs535536030       rs535706837       rs536144791       rs536220735       rs536281241       rs536364532       rs536676640       rs537000588       rs537338003       rs538018097       rs538049279       rs538053083       rs538137060       rs538343989       rs538806796       rs538843785       rs539054379       rs539993470       rs540053071       rs540619049       rs540731102       rs540917356       rs540976884       rs541181610       rs541328778       rs541584879       rs541643972       rs541647876       rs541649658       rs541710193       rs542345856       rs542608444       rs542963349       rs543318257       rs543471660       rs543536163       rs543577108       rs543744942       rs544049038       rs544583519       rs544644925       rs544678760       rs544707880       rs544784388       rs545043536       rs545462096       rs545562179       rs545635786       rs545674316       rs545691651       rs546726559       rs546792031       rs546916533       rs546959189       rs547296150       rs547554908       rs548277648       rs549012198       rs549054150       rs549238144       rs549273850       rs549361716       rs549517354       rs549771544       rs549847213       rs549921056       rs550043063       rs550118078       rs550280569       rs550990261       rs551755200       rs551988573       rs552198240       rs552270392       rs552529830       rs552733171       rs552863859       rs552910307       rs553570097       rs554201016       rs554239972       rs554659930       rs554661448       rs554716420       rs554723255       rs555656820       rs556001434       rs556174605       rs556699615       rs556714182       rs556714368       rs556731955       rs556909725       rs557013044       rs557569061       rs557632683       rs558511338       rs558646450       rs558723842       rs558737162       rs558755981       rs559052086       rs559083542       rs559668874       rs560204484       rs560490243       rs560778578       rs560862643       rs561200829       rs561917041       rs562049812       rs562217422       rs562277757       rs562937016       rs563200428       rs563209224       rs563262266       rs563413626       rs563473542       rs563946435       rs564004198       rs564191841       rs564258197       rs564398753       rs565067923       rs565728407       rs566447221       rs567043991       rs567056505       rs567830116       rs567846084       rs568032104       rs568487043       rs568651015       rs568675144       rs568738562       rs568934335       rs569445134       rs569483776       rs569490373       rs569544489       rs569848170       rs570061479       rs570500914       rs571083301       rs572149968       rs572216496       rs572407210       rs572632781       rs572721373       rs572847021       rs573597388       rs573796572       rs574078478       rs574183988       rs574232084       rs574312084       rs574661862       rs574941219       rs575688350       rs575831754       rs576044400       rs576192730       rs576253560       rs576314853       rs576701235       rs576838153       rs577045337       rs577098816       rs577104493       rs577369126       rs577531867       rs578115571       rs578116923       rs578179520       rs745453513       rs745739198       rs745760429       rs745764048       rs745824940       rs745983593       rs746124875       rs746388090       rs746587109       rs746843730       rs746878731       rs746966263       rs747129206       rs747129281       rs747259936       rs747375477       rs747470868       rs747509077       rs747684225       rs747696767       rs747914581       rs747960307       rs748002881       rs748715864       rs748871049       rs748872362       rs748883056       rs748974541       rs749104168       rs749500595       rs749822150       rs749881834       rs749923592       rs750299240       rs750472259       rs750560113       rs750562166       rs750616313       rs751126274       rs751428587       rs751581970       rs751970160       rs752062644       rs752209180       rs752331296       rs752510060       rs752532001       rs752798729       rs752820603       rs752971729       rs753169678       rs753209535       rs753458087       rs753464996       rs753649047       rs753892861       rs753987251       rs754010984       rs754041228       rs754312331       rs754530001       rs754725952       rs754905831       rs755243107       rs755261552       rs755426651       rs755512741       rs755840023       rs755887246       rs756074826       rs756363104       rs756396032       rs756499914       rs756752692       rs756957921       rs756969903       rs756984182       rs757279605       rs757301291       rs757311287       rs757468761       rs757731165       rs757850023       rs757878186       rs757987852       rs758619136       rs758726344       rs758959937       rs759015669       rs759177905       rs759301871       rs759463984       rs759700161       rs760156398       rs760407773       rs760560169       rs760676770       rs760805323       rs761072285       rs761526932       rs761826317       rs761849141       rs761928219       rs762013111       rs762261195       rs762349411       rs762578814       rs762596814       rs762887143       rs763098966       rs763137346       rs763190718       rs763266989       rs763686551       rs763978824       rs764068836       rs764465134       rs764585545       rs764794281       rs764841326       rs765063665       rs765245897       rs765329435       rs765335966       rs765425816       rs765512122       rs765545880       rs765568201       rs765672149       rs765866952       rs765993097       rs766012994       rs766020525       rs766218046       rs766375778       rs766467977       rs766958737       rs767034552       rs767086661       rs767154683       rs767370738       rs767395614       rs767474385       rs767886842       rs767932993       rs768135691       rs768396595       rs768409683       rs768590866       rs768845756       rs768853561       rs769113192       rs769188214       rs769267219       rs769496984       rs769828679       rs769977037       rs769983589       rs770071555       rs770213494       rs770528717       rs770635458       rs770754479       rs770972381       rs771026474       rs771114424       rs771199877       rs771244571       rs771487677       rs771690497       rs771779980       rs771786695       rs771792293       rs771876675       rs772060123       rs772124780       rs772214871       rs772242506       rs772764942       rs772807380       rs772820924       rs772832695       rs773372861       rs773577246       rs773617744       rs773820400       rs773920326       rs774207671       rs774289700       rs774306202       rs774385200       rs774484947       rs774680893       rs774712936       rs774959386       rs775034465       rs775145036       rs775281620       rs775369845       rs775708161       rs775726637       rs775774203       rs775976001       rs775997944       rs776102697       rs776411817       rs776852485       rs776921243       rs777026848       rs777232484       rs777436497       rs777606593       rs777618710       rs777832715       rs777938183       rs778193117       rs778314981       rs778861991       rs778885373       rs778896112       rs779246152       rs779824297       rs780012359       rs780091913       rs780271583       rs780279184       rs780518050       rs780581104       rs780850116       rs781147313       rs781306636       rs781349708       rs781498907       rs781643146       rs869275910      

UNG基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGTTGTCTACAGACATAGAGGA
58
GAGAAGGAGAACACCTTGC
58
CGGATCCAGAGGAACAAGG
60
TTCTTCTGCAACAAATCCCA
58
TATCATGGACCTAATCAAGCTC
58
AATGTTCTCCAAACTGGGC
58
CGGATCCAGAGGAACAAGG
60
CTTTCTTCTGCAACAAATCCCA
60
GCTAATGGGATTTGTTGCAG
58
CAGGTGAAGACTTGGTGTG
58
CAGTGCCATTGATAGGAAGC
59
CCAAAGAACCCTCTATACACTG
58
CATGGACCTAATCAAGCTCAC
59
ATAAATGTTCTCCAAACTGGGC
59
ACCAAGTCTTCACCTGGAC
59
GAGAAGGAGAACACCTTGCT
60
GCTAATGGGATTTGTTGCAG
58
AGGTGAAGACTTGGTGTGG
60
CATGGACCTAATCAAGCTCAC
59
ATAAATGTTCTCCAAACTGGGC
59
      尚未收录相关数据

UNG基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

UNG基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0004844
F5GYA2(UniProtKB)
IEA
GO:0006284
F5GYA2(UniProtKB)
IEA
GO:0003684
P13051(UniProtKB)
IDA
GO:0004844
P13051(UniProtKB)
NAS
GO:0004844
P13051(UniProtKB)
TAS
GO:0004844
P13051(UniProtKB)
TAS
GO:0005515
P13051(UniProtKB)
IPI
GO:0005515
P13051(UniProtKB)
IPI
GO:0005634
P13051(UniProtKB)
NAS
GO:0005654
P13051(UniProtKB)
TAS
GO:0005654
P13051(UniProtKB)
TAS
GO:0005654
P13051(UniProtKB)
TAS
GO:0005654
P13051(UniProtKB)
TAS
GO:0005654
P13051(UniProtKB)
TAS
GO:0005739
P13051(UniProtKB)
IEA
GO:0006281
P13051(UniProtKB)
TAS
GO:0006284
P13051(UniProtKB)
TAS
GO:0016032
P13051(UniProtKB)
IEA
GO:0016446
P13051(UniProtKB)
IEA
GO:0016447
P13051(UniProtKB)
IEA
GO:0019899
P13051(UniProtKB)
IPI
GO:0043066
P13051(UniProtKB)
IEA
GO:0045008
P13051(UniProtKB)
TAS
GO:0045008
P13051(UniProtKB)
TAS
GO:0045830
P13051(UniProtKB)
IEA
GO:0097510
P13051(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控UNG基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hyper-IgM Immunodeficiency Syndrome, Type 5 0.36 1 1 CLINVAR_ORPHANET_UNIPROT
Colorectal Neoplasms 0.12272435 2 0 CTD_human_LHGDN
Hyperimmunoglobulin M syndrome 0.121628651 6 0 BeFree_CTD_human
Bloom Syndrome 0.120271442 2 0 BeFree_CTD_human
Malignant neoplasm of prostate 0.002638474 2 0 BeFree_GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
DNA Damage 0.002367032 1 0 GAD
Graft-vs-Host Disease 0.002367032 1 0 GAD
Immunologic Deficiency Syndromes 0.002367032 1 0 GAD
Severe Combined Immunodeficiency 0.002367032 1 0 GAD
Hematologic Neoplasms 0.002367032 1 0 GAD
HIV Infections 0.001628651 6 0 BeFree
Hyper-IgM Immunodeficiency Syndrome, Type 1 0.001628651 6 0 BeFree
Malignant tumor of colon 0.000542884 2 0 BeFree
Esophageal Neoplasms 0.000542884 2 1 BeFree
Glioblastoma 0.000542884 2 0 BeFree
Lymphoma 0.000542884 2 0 BeFree
Esophageal carcinoma 0.000542884 2 1 BeFree
Malignant neoplasm of esophagus 0.000542884 2 1 BeFree
Colon Carcinoma 0.000542884 2 0 BeFree
Recurrent infections (sinusitis and bacterial pneumonia and meningitis) 0.000542884 2 0 BeFree
Blast Phase 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Colorectal Carcinoma 0.000271442 1 0 BeFree
Herpes Simplex Infections 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Acute lymphocytic leukemia 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Cerebrovascular accident 0.000271442 1 0 BeFree
Acute leukemia 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Vesicular Stomatitis 0.000271442 1 0 BeFree
Squamous cell carcinoma of esophagus 0.000271442 1 1 BeFree
Primary immune deficiency disorder 0.000271442 1 0 BeFree
hiv-infection/aids 0.000271442 1 0 BeFree
Neurodegenerative Disorders 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Precursor B-cell lymphoblastic leukemia 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000271442 1 0 BeFree
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