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The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的酶在哺乳动物碳水化合物相互转化的重要媒介。它由葡萄糖-1-磷酸葡萄糖部分转移到MgUTP并形成UDP-葡萄糖和MgPPi。在肝脏和肌肉组织,UDP葡萄糖是糖原的直接前体;在哺乳期乳腺它被转换成UDP-半乳糖,然后转化为乳糖。真核酶具有无显著序列相似性的原核酶。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的,2008年7月提供]
UGP2基因(以及对应的蛋白质)的细胞分布位置:
UGP2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hyperbilirubinemia, Neonatal | 0.002367032 | 1 | 0 | GAD |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
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