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This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码具有不同的C端UBX结构域的蛋白。在大鼠同源蛋白质的Rho GTP酶在通过其C-末端区域的小区外围的Rnd亚家族成员相互作用。它也通过自己的G-α亚几个异体G蛋白相互作用,促进卢GTP酶激活。建议将服务于促进和Rho活性的抑制通过上游信号通路的双向作用。此基因的3‘编码序列中含有的24个核苷酸串联重复一个polymoprhic区域。据报道含有1.5至五岁的重复单元的几个成绩单。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的,2008年7月提供]
UBXN11基因(以及对应的蛋白质)的细胞分布位置:
UBXN11基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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