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This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
[中文简述(自动翻译):]  这个基因编码属于酪氨酸酶家族并播放在黑色素生物合成途径中起重要作用一个melanosomal酶。这种基因缺陷是红褐色白化病眼和白化病眼III型的原因。 [由RefSeq的,2009年03月提供]
TYRP1基因(以及对应的蛋白质)的细胞分布位置:
TYRP1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Oculocutaneous albinism type 3 | 0.241357209 | 5 | 0 | BeFree_CTD_human_ORPHANET |
| ALBINISM, OCULOCUTANEOUS, TYPE III | 0.240542884 | 4 | 1 | BeFree_ORPHANET_UNIPROT |
| Adenocarcinoma | 0.12 | 1 | 0 | CTD_human |
| Lung Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Skin/Hair/Eye Pigmentation, Variation In, 11 | 0.12 | 0 | 1 | CLINVAR |
| melanoma | 0.021692944 | 37 | 1 | BeFree_GAD_LHGDN |
| Albinism, Oculocutaneous | 0.019345775 | 19 | 0 | BeFree_GAD_LHGDN |
| Basal cell carcinoma | 0.004734064 | 2 | 0 | GAD |
| Skin Neoplasms | 0.004734064 | 2 | 0 | GAD |
| Albinism, Ocular | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.003452799 | 5 | 0 | BeFree_GAD |
| Melanoma, Amelanotic | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.002638474 | 2 | 0 | BeFree_GAD |
| Albinism | 0.001900093 | 7 | 1 | BeFree |
| Microphthalmos | 0.001357209 | 5 | 0 | BeFree |
| Vitiligo | 0.001357209 | 5 | 1 | BeFree |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 0.001357209 | 5 | 1 | BeFree |
| Hypopigmentation disorder | 0.001085767 | 4 | 0 | BeFree |
| Leigh Disease | 0.000814326 | 3 | 0 | BeFree |
| Cutaneous Melanoma | 0.000814326 | 3 | 0 | BeFree |
| Asthma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| Cardiovascular Diseases | 0.000542884 | 2 | 0 | BeFree |
| Cholera | 0.000542884 | 2 | 0 | BeFree |
| Glaucoma | 0.000542884 | 2 | 0 | BeFree |
| Focal glomerulosclerosis | 0.000542884 | 2 | 0 | BeFree |
| Hypobetalipoproteinemias | 0.000542884 | 2 | 0 | BeFree |
| Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
| Polycystic Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
| Retinal Degeneration | 0.000542884 | 2 | 0 | BeFree |
| Hermanski-Pudlak Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Polycystic Kidney, Autosomal Dominant | 0.000542884 | 2 | 0 | BeFree |
| Secondary malignant neoplasm of skin | 0.000542884 | 2 | 0 | BeFree |
| Mitochondrial Myopathies | 0.000542884 | 2 | 0 | BeFree |
| Uveal melanoma | 0.000542884 | 2 | 0 | BeFree |
| Mucolipidosis Type IV | 0.000542884 | 2 | 0 | BeFree |
| Hantavirus Infections | 0.000542884 | 2 | 0 | BeFree |
| Oculocutaneous albinism type 2 | 0.000542884 | 2 | 0 | BeFree |
| Brown oculocutaneous albinism | 0.000542884 | 2 | 0 | BeFree |
| Metastatic melanoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Primary Lesion | 0.000542884 | 2 | 0 | BeFree |
| Tumor Immunity | 0.000542884 | 2 | 0 | BeFree |
| Channelopathies | 0.000542884 | 2 | 0 | BeFree |
| Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
| Melanoma, B16 | 0.000271442 | 1 | 0 | BeFree |
| Bladder neck obstruction | 0.000271442 | 1 | 0 | BeFree |
| Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Chediak-Higashi Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Coughing | 0.000271442 | 1 | 0 | BeFree |
| Graves Disease | 0.000271442 | 1 | 0 | BeFree |
| Iris Diseases | 0.000271442 | 1 | 0 | BeFree |
| Liver diseases | 0.000271442 | 1 | 0 | BeFree |
| Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Nicotine Dependence | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Prolactinoma | 0.000271442 | 1 | 0 | BeFree |
| Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Retroviridae Infections | 0.000271442 | 1 | 0 | BeFree |
| Senile lentigo | 0.000271442 | 1 | 0 | BeFree |
| Thyroiditis | 0.000271442 | 1 | 0 | BeFree |
| Ataxia, Spinocerebellar | 0.000271442 | 1 | 0 | BeFree |
| Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Pelizaeus-Merzbacher Disease | 0.000271442 | 1 | 0 | BeFree |
| Renal glomerular disease | 0.000271442 | 1 | 0 | BeFree |
| Erythroblastosis | 0.000271442 | 1 | 0 | BeFree |
| Interstitial Cystitis | 0.000271442 | 1 | 0 | BeFree |
| Senile Plaques | 0.000271442 | 1 | 0 | BeFree |
| Common Migraine | 0.000271442 | 1 | 0 | BeFree |
| Hypothyroidism, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of eye | 0.000271442 | 1 | 0 | BeFree |
| Pigmentation Disorders | 0.000271442 | 1 | 0 | BeFree |
| Chronic interstitial cystitis | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Disorder of circulatory system | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Degenerative disorder | 0.000271442 | 1 | 0 | BeFree |
| indolent lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Breast Cancer Model | 0.000271442 | 1 | 0 | BeFree |
| Lubs X-linked mental retardation syndrome | 0.000271442 | 1 | 0 | BeFree |
| ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT | 0.000271442 | 1 | 0 | BeFree |
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