TYROBP(TYRO protein tyrosine kinase binding protein) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

19q13.1
基因染色体位置图

基因简述

基因简述

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

[中文简述(自动翻译):]  该基因编码含有在其胞质结构域中包含免疫受体基于酪氨酸的活化基序（ITAM）的跨膜信号多肽。所编码的蛋白质可与杀伤细胞抑制性受体（KIR）家族的膜糖蛋白的关联，并且可以作为活化的信号转导元件起作用。这种蛋白质可结合泽塔链（TCR）相关的蛋白激酶的70kDa（ZAP-70）和脾酪氨酸激酶（SYK），并起到信号转导，骨造型，脑髓鞘和炎症的作用。该基因内突变已与硬化性白质脑病（PLOSL），也被称为那须Hakola疾病多囊卵巢lipomembranous osteodysplasia相关联。其公认的受体，触发受体骨髓细胞2（TREM2）表示，也导致PLOSL。编码不同亚型多重替代转录变异体已经确定了这个基因。 [由RefSeq的，2010年3月提供]

OMIM数据库中对TYROBP基因的介绍     Wikipedia数据库中对TYROBP基因的介绍

基因序列

基因序列

TYROBP基因的碱基序列：[NCBI]

基因突变

基因突变

TYROBP基因的碱基突变：           显示全部snp
rs14714       rs14715       rs1802029       rs8105153       rs8106480       rs74610942       rs75330483       rs113207157       rs140727973       rs142104996       rs182961452       rs200170675       rs369642701       rs370284045       rs371385905       rs372342355       rs372703196       rs372752422       rs374144427       rs375669695       rs377005575       rs377053543       rs527843270       rs530939080       rs531538169       rs532374582       rs532421415       rs535044925       rs535324953       rs536334516       rs537669436       rs543624561       rs548319966       rs553707275       rs554715202       rs560842931       rs564959565      
rs570998790       rs572118598       rs577447631       rs746181466       rs747352673       rs748878521       rs748930067       rs749346621       rs749733504       rs750297296       rs751308673       rs752310044       rs752823661       rs752946415       rs753344650       rs754984262       rs756121440       rs756499489       rs757023436       rs757153648       rs757922185       rs758119257       rs758658889       rs758917899       rs759398516       rs759574268       rs759623505       rs760562825       rs760954757       rs761226731       rs762133333       rs763032963       rs764226429       rs765270571       rs765393175       rs766372791       rs766427839       rs766860068       rs767191379       rs767843323       rs768291126       rs768476694       rs769390278       rs769463279       rs770226921       rs770353302       rs770378097       rs771413481       rs773078824       rs773617916       rs774535634       rs775997204       rs777094340       rs778446613       rs778590214       rs779755179       rs780434005       rs3817624       rs4471822       rs4806226       rs4806227       rs7258962       rs7260613       rs8110231       rs8110427       rs8111736       rs8113524       rs11880279       rs17173033       rs17549166       rs17549173       rs55746266       rs56006731       rs56212006       rs56376371       rs57412339       rs57516855       rs59399698       rs59478831       rs59534183       rs62109667       rs73928359       rs74590995       rs77479541       rs77761899       rs77782321       rs78458519       rs79272253       rs79786712       rs80136078       rs111477177       rs111480245       rs111590553       rs113535461       rs113607493       rs113824165       rs114090962       rs116388114       rs116794076       rs116987202       rs117350916       rs117745591       rs118043958       rs138731084       rs138857948       rs138901102       rs138937131       rs139153723       rs140101562       rs140188939       rs140640339       rs141267143       rs141918323       rs142620676       rs142760556       rs142807700       rs143352776       rs143768611       rs143990386       rs144188402       rs144743306       rs146068432       rs146831722       rs147393700       rs148335315       rs148343651       rs148442561       rs149422407       rs150310136       rs150586091       rs151172291       rs151204635       rs181379124       rs181428328       rs182039612       rs182929423       rs184572638       rs184582489       rs184784706       rs185541298       rs186248565       rs187745232       rs188984802       rs189439639       rs190453095       rs190693630       rs190770363       rs191505576       rs192987338       rs199583341       rs199707205       rs199931680       rs199970556       rs200264632       rs200283667       rs200634946       rs200649978       rs200686862       rs200694727       rs201241122       rs201257797       rs201680032       rs201813149       rs202135885       rs367583790       rs368252168       rs368476838       rs368573395       rs369808065       rs370767403       rs371944485       rs371976856       rs372140827       rs372455462       rs373277724       rs373306748       rs376287189       rs376453383       rs377262357       rs386833840       rs528969263       rs529603250       rs530010344       rs530162071       rs531626554       rs532376836       rs532465899       rs533282889       rs533744083       rs534107069       rs534412791       rs534447410       rs535284232       rs536268270       rs536461059       rs536649247       rs537144220       rs537378103       rs537906273       rs538254188       rs539753403       rs539823212       rs540878972       rs541802004       rs544216142       rs545313310       rs545336238       rs545730787       rs545900874       rs546257418       rs547449906       rs547486942       rs549264738       rs549427076       rs550135762       rs550694639       rs551034672       rs551142884       rs551213049       rs551666824       rs551673222       rs551873114       rs552008509       rs553976057       rs554589565       rs556371190       rs557854792       rs558369784       rs558997709       rs560431257       rs561260120       rs561379728       rs562302795       rs562618579       rs563132881       rs563691426       rs565234617       rs565640667       rs566347919       rs567403624       rs567874253       rs568839666       rs568910366       rs569034090       rs570283829       rs570307095       rs570432958       rs570978910       rs571229328       rs571593934       rs571695428       rs573318524       rs573357888       rs573523161       rs574376473       rs577649862       rs577778644       rs745610215       rs745910229       rs746359458       rs746506929       rs747153455       rs747212988       rs747461833       rs748132054       rs748268148       rs749207597       rs750455140       rs750536324       rs751429558       rs751872815       rs753219755       rs753458951       rs753979118       rs754032685       rs754097137       rs754196897       rs754524303       rs754719552       rs754801907       rs755244402       rs756345678       rs756641773       rs756950430       rs757194021       rs757320241       rs757443299       rs757488165       rs757651694       rs758290972       rs759024155       rs759301317       rs759379709       rs759389250       rs759752532       rs760287368       rs760363848       rs760509495       rs760746842       rs761288020       rs761446440       rs761718324       rs762095737       rs762153343       rs762374639       rs762708303       rs762916364       rs763081510       rs763570752       rs763695211       rs763781935       rs763988217       rs764381318       rs765397155       rs765613710       rs766014534       rs766428957       rs767032012       rs767157247       rs767519602       rs767572535       rs767648127       rs768644319       rs768760619       rs769117922       rs769567799       rs769635655       rs769840656       rs770315263       rs770560742       rs771338028       rs771371224       rs771498196       rs771582920       rs771964613       rs772366298       rs772952999       rs773594217       rs773619483       rs773677253       rs773779731       rs773956454       rs774298388       rs774787743       rs775196278       rs775339428       rs775527423       rs775607575       rs775695088       rs775930876       rs776619212       rs777988814       rs778000401       rs778041106       rs778668986       rs778849558       rs779491857       rs779590517       rs780380872       rs780898439       rs781498043       rs781578088      

基因表达

基因表达

TYROBP基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
ATTGCAGTTGCTCTACGGT
60
CTGGAGCTCCTGATAAGGC
60
CCTTACACTGTGGTGTCCA
59
GTAGAGCAACTGCAATCGC
60
CCTTACACTGTGGTGTCCA
59
GGACGGAGACCACTTACAG
60
CCTTACACTGTGGTGTCCA
59
TAGAGCAACTGCAATCGCT
60
CTGTAAGTGATTGCAGTTGCT
59
CAATGAGCACTGTCAGCAC
60
CTGGCTGTAAGTGGTCTCC
60
CAATGAGCACTGTCAGCAC
60
CTGTAAGTGGTCTCCGTCC
60
CAATGAGCACTGTCAGCAC
60
AACACCCTCAACTCACCAC
60
CTGGAGCTCCTGATAAGGC
60
CTGGCTGTAAGTGATTGCAG
59
CAATGAGCACTGTCAGCAC
60
GATTGCAGTTGCTCTACGG
59
CTGGAGCTCCTGATAAGGC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

TYROBP基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TYROBP基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0016021
K7ES93(UniProtKB)
IEA
GO:0002281
O43914(UniProtKB)
IEA
GO:0002283
O43914(UniProtKB)
IEA
GO:0005057
O43914(UniProtKB)
TAS
GO:0005102
O43914(UniProtKB)
IPI
GO:0005102
O43914(UniProtKB)
IPI
GO:0005102
O43914(UniProtKB)
IPI
GO:0005515
O43914(UniProtKB)
IPI
GO:0005515
O43914(UniProtKB)
IPI
GO:0005515
O43914(UniProtKB)
IPI
GO:0005622
O43914(UniProtKB)
IEA
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005886
O43914(UniProtKB)
TAS
GO:0005887
O43914(UniProtKB)
TAS
GO:0006968
O43914(UniProtKB)
TAS
GO:0007165
O43914(UniProtKB)
TAS
GO:0007229
O43914(UniProtKB)
IEA
GO:0009986
O43914(UniProtKB)
IDA
GO:0035556
O43914(UniProtKB)
TAS
GO:0042802
O43914(UniProtKB)
IPI
GO:0045087
O43914(UniProtKB)
TAS
GO:0050776
O43914(UniProtKB)
TAS
GO:2001204
O43914(UniProtKB)
IEA
GO:0016021
X6RGC9(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控TYROBP基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY 0.442985861 11 5 BeFree_CLINVAR_CTD_human_MGD_ORPHANET
IGA Glomerulonephritis 0.12 1 0 CTD_human
Liver diseases 0.12 1 0 CTD_human
Inflammation 0.00272435 1 0 LHGDN
Malignant neoplasm of ovary 0.002367032 1 0 GAD
Presenile dementia 0.001628651 6 0 BeFree
Bone Cysts 0.001085767 4 0 BeFree
Dementia 0.000814326 3 0 BeFree
Rheumatoid Arthritis 0.000542884 2 0 BeFree
Schizophrenia 0.000542884 2 0 BeFree
Leukoencephalopathies 0.000542884 2 0 BeFree
Osteodysplasia 0.000542884 2 0 BeFree
Autoimmune Diseases 0.000271442 1 0 BeFree
Mental disorders 0.000271442 1 0 BeFree
Demyelinating Diseases 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Kidney Diseases 0.000271442 1 0 BeFree
Lupus Erythematosus, Systemic 0.000271442 1 0 BeFree
oligodendroglioma 0.000271442 1 0 BeFree
Ureteral obstruction 0.000271442 1 0 BeFree
Obstructive nephropathy 0.000271442 1 0 BeFree
Lung infiltration 0.000271442 1 0 BeFree
Pilocytic Astrocytoma 0.000271442 1 0 BeFree
Well Differentiated Oligodendroglioma 0.000271442 1 0 BeFree
Leukemia, Large Granular Lymphocytic 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

没有相关文献

基因相关服务

基因相关服务

基因评论

基因评论

我要说两句
热门评论
还没有评论，赶快来抢沙发吧。

登陆

用户名:

密    码:

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

扫一扫右方二维码，关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2016.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2