更多...
收起
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  碱性螺旋 - 环 - 螺旋(bHLH)结构的转录因子有牵连的细胞谱系的决心和分化。由该基因编码的蛋白质是一个的bHLH转录因子和共享相似性与其他的bHLH转录因子,Dermo1。此mRNA的表达最强的是胎盘组织;在成人中,中胚层衍生组织优先表达这种基因。在这种基因突变的患者Saethre-Chotzen综合征被发现。 [由RefSeq的,2008年7月提供]
TWIST1基因(以及对应的蛋白质)的细胞分布位置:
TWIST1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Saethre-Chotzen Syndrome | 0.452214884 | 46 | 11 | BeFree_CLINVAR_MGD_ORPHANET_UNIPROT |
Craniosynostosis | 0.266131822 | 42 | 0 | BeFree_CTD_human_GAD_LHGDN_UNIPROT |
Saethre-Chotzen Syndrome with Eyelid Anomalies | 0.24 | 1 | 1 | CLINVAR_CTD_human |
Neoplasm Metastasis | 0.148541123 | 67 | 0 | BeFree_CTD_human_LHGDN |
Stomach Neoplasms | 0.125720142 | 4 | 0 | BeFree_CTD_human_LHGDN |
Acrocephalosyndactylia | 0.1254487 | 4 | 0 | CTD_human_LHGDN |
Obesity | 0.120814326 | 4 | 1 | BeFree_GWASCAT |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
Cerebrovascular accident | 0.12 | 1 | 1 | GWASCAT |
Robinow Sorauf syndrome | 0.12 | 0 | 1 | CLINVAR |
Malignant neoplasm of breast | 0.011867498 | 36 | 0 | BeFree_GAD |
Mammary Neoplasms | 0.00953026 | 8 | 0 | BeFree_LHGDN |
Breast Carcinoma | 0.009229024 | 34 | 0 | BeFree |
Liver carcinoma | 0.007891677 | 11 | 0 | BeFree_LHGDN |
Pancreatic Neoplasm | 0.0054487 | 2 | 0 | LHGDN |
Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Congenital abnormal Synostosis | 0.004895885 | 8 | 0 | BeFree_LHGDN |
Non-Small Cell Lung Carcinoma | 0.004538567 | 9 | 0 | BeFree_GAD |
Squamous cell carcinoma | 0.00408156 | 6 | 0 | BeFree_LHGDN |
melanoma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Osteosarcoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Prostate carcinoma | 0.003800186 | 14 | 0 | BeFree |
Malignant neoplasm of ovary | 0.003724241 | 6 | 0 | BeFree_GAD |
Glioma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Sezary Syndrome | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Malignant neoplasm of prostate | 0.003257302 | 12 | 0 | BeFree |
Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Ulcerative Colitis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Malignant neoplasm of stomach | 0.002985861 | 11 | 0 | BeFree |
Anoxia | 0.00272435 | 1 | 0 | LHGDN |
Crohn Disease | 0.00272435 | 1 | 0 | LHGDN |
Rheumatism | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of lung | 0.002714419 | 10 | 0 | BeFree |
Carcinoma of lung | 0.002714419 | 10 | 0 | BeFree |
Stomach Carcinoma | 0.002714419 | 10 | 0 | BeFree |
Colorectal Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Carcinogenesis | 0.002442977 | 9 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.002442977 | 9 | 0 | BeFree |
Chromosome Aberrations | 0.002367032 | 1 | 0 | GAD |
Tumor Progression | 0.002171535 | 8 | 0 | BeFree |
Colorectal Cancer | 0.002171535 | 8 | 0 | BeFree |
Chronic sinusitis | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.001357209 | 5 | 0 | BeFree |
Nasal Polyps | 0.001357209 | 5 | 0 | BeFree |
Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Carcinoma of bladder | 0.001357209 | 5 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
Deformity of limb | 0.001085767 | 4 | 0 | BeFree |
Cervix carcinoma | 0.001085767 | 4 | 0 | BeFree |
Congenital Abnormality | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of cervix | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000814326 | 3 | 0 | BeFree |
Esophageal carcinoma | 0.000814326 | 3 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000814326 | 3 | 0 | BeFree |
Developmental delay (disorder) | 0.000814326 | 3 | 0 | BeFree |
Endometrial Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Thyroid carcinoma | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
Metastatic Prostate Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Apert syndrome | 0.000542884 | 2 | 2 | BeFree |
Malignant neoplasm of endometrium | 0.000542884 | 2 | 0 | BeFree |
Colorectal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Phyllodes Tumor | 0.000542884 | 2 | 0 | BeFree |
Esophageal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Sensorineural Hearing Loss (disorder) | 0.000542884 | 2 | 0 | BeFree |
Lung Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Lymphohistiocytosis, Hemophagocytic | 0.000542884 | 2 | 0 | BeFree |
Metabolic Diseases | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
polyps | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000542884 | 2 | 0 | BeFree |
Hypopharyngeal Cancer | 0.000542884 | 2 | 0 | BeFree |
Giant Cell Tumor of Bone | 0.000542884 | 2 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Baller-Gerold syndrome | 0.000542884 | 2 | 0 | BeFree |
Scaphycephaly | 0.000542884 | 2 | 2 | BeFree |
Congenital premature fusion | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of tongue | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Invasive Ductal Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenoma of large intestine | 0.000542884 | 2 | 0 | BeFree |
Hypopharyngeal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000542884 | 2 | 0 | BeFree |
Uterine Corpus Cancer | 0.000542884 | 2 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenoma | 0.000271442 | 1 | 0 | BeFree |
Ameloblastoma | 0.000271442 | 1 | 0 | BeFree |
Arthritis | 0.000271442 | 1 | 0 | BeFree |
Bladder Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Blepharoptosis | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Breast Fibrocystic Disease | 0.000271442 | 1 | 0 | BeFree |
Graft-vs-Host Disease | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Atrial Septal Defects | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
Mental Retardation | 0.000271442 | 1 | 0 | BeFree |
Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Preleukemia | 0.000271442 | 1 | 0 | BeFree |
Ptosis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Edema | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Rubinstein-Taybi Syndrome | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Syndactyly | 0.000271442 | 1 | 0 | BeFree |
Fibromatosis, Aggressive | 0.000271442 | 1 | 0 | BeFree |
Intracranial Hypertension | 0.000271442 | 1 | 0 | BeFree |
Polydactyly | 0.000271442 | 1 | 0 | BeFree |
Stage 0 Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Choroid Plexus Papilloma | 0.000271442 | 1 | 0 | BeFree |
Fibroadenoma | 0.000271442 | 1 | 0 | BeFree |
Medullary carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Limb Deformities, Congenital | 0.000271442 | 1 | 0 | BeFree |
Brachydactyly | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
bone destruction | 0.000271442 | 1 | 0 | BeFree |
Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
Interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
Congenital clinodactyly | 0.000271442 | 1 | 0 | BeFree |
Congenital anomaly of face | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Lobular carcinoma in situ of breast | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of tonsil | 0.000271442 | 1 | 0 | BeFree |
Non-infiltrating lobular carcinoma | 0.000271442 | 1 | 0 | BeFree |
Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Disseminated Malignant Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Craniofacial Abnormalities | 0.000271442 | 1 | 0 | BeFree |
Nodular fasciitis | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
invasive cancer | 0.000271442 | 1 | 0 | BeFree |
Brain Tumor, Primary | 0.000271442 | 1 | 0 | BeFree |
Learning Disabilities | 0.000271442 | 1 | 0 | BeFree |
Malignant Peripheral Nerve Sheath Tumor | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Vitamin B 6 Deficiency | 0.000271442 | 1 | 0 | BeFree |
Cytokine release syndrome | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Chronic inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
Prominent ear | 0.000271442 | 1 | 0 | BeFree |
Anaplastic Large Cell Lymphoma, ALK-Positive | 0.000271442 | 1 | 0 | BeFree |
Mesenchymal Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Differentiated Thyroid Gland Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Epithelioma | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
Malignant Conversion | 0.000271442 | 1 | 0 | BeFree |
androgen independent prostate cancer | 0.000271442 | 1 | 0 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Synostotic Anterior Plagiocephaly | 0.000271442 | 1 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。