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The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质属于一组泛素结合酶的明显无活性同系物的。的基因产物包含与stathmin的,胞质磷蛋白在肿瘤牵连相互作用的卷曲螺旋结构域。该蛋白可能在细胞生长和分化并充当一个角色作为负生长调节剂。在这种肿瘤易感基因的体外稳态表达似乎是维护基因组稳定性和细胞周期调控的重要。突变和选择性剪接在这个基因发生在乳腺癌高频并表明乳腺癌肿瘤发生和/或进展过程中发生的缺陷。 [由RefSeq的,2008年7月提供]
TSG101基因(以及对应的蛋白质)的细胞分布位置:
TSG101基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Breast Cancer, Familial | 0.120814326 | 3 | 0 | BeFree_CLINVAR |
| Malignant neoplasm of breast | 0.005700279 | 21 | 0 | BeFree |
| ovarian neoplasm | 0.0054487 | 2 | 0 | LHGDN |
| Breast Carcinoma | 0.004885954 | 18 | 0 | BeFree |
| Carcinogenesis | 0.004614512 | 17 | 0 | BeFree |
| Malignant neoplasm of lung | 0.003181358 | 4 | 0 | BeFree_GAD |
| HIV Infections | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
| Hepatitis C | 0.002367032 | 1 | 0 | GAD |
| Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
| Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
| Ovarian Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
| Cervix carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
| Charcot-Marie-Tooth Disease | 0.000542884 | 2 | 0 | BeFree |
| leukemia | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
| Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
| Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Burkitt Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Charcot-Marie-Tooth disease, Type 1C | 0.000271442 | 1 | 0 | BeFree |
| Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Solid tumour | 0.000271442 | 1 | 0 | BeFree |
| Human papilloma virus infection | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gastrointestinal tract | 0.000271442 | 1 | 0 | BeFree |
| Uterine carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Breast adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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