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This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Feb 2015]
[中文简述(自动翻译):]  该基因编码一个家族多通路的膜蛋白,其功能作为钙通道的成员。所编码的蛋白质包含N末端锚蛋白重复序列??,其中所需的信道装配和调节。密码子被解码为蛋氨酸这种蛋白质翻译起始发生在非AUG起始。该基因旁边有一个密切相关的基因瞬时受体电位阳离子通道亚家族V成员5(TRPV5)位于。该位点已经历阳性选择在非非洲群,从而导致不??同的遗传背景的个体中的几个非同义密码子的差异。 [由RefSeq的,2015年2月提供]
TRPV6基因(以及对应的蛋白质)的细胞分布位置:
TRPV6基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Polycystic Ovary Syndrome | 0.12 | 1 | 0 | CTD_human |
Malignant neoplasm of prostate | 0.00643866 | 15 | 0 | BeFree_GAD |
Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Prostate carcinoma | 0.003800186 | 14 | 0 | BeFree |
Adenocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
Bipolar Disorder | 0.00272435 | 1 | 0 | LHGDN |
Hypercalciuria | 0.002638474 | 1 | 0 | BeFree_GAD |
Cri-du-Chat Syndrome | 0.002442977 | 9 | 0 | BeFree |
Kidney Calculi | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.001628651 | 6 | 0 | BeFree |
Breast Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.001085767 | 4 | 0 | BeFree |
Mental Retardation | 0.000814326 | 3 | 0 | BeFree |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cri du chat | 0.000542884 | 2 | 0 | BeFree |
Speech Delay | 0.000542884 | 2 | 0 | BeFree |
Developmental delay (disorder) | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of prostate | 0.000271442 | 1 | 0 | BeFree |
Uterine Cervical Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Hypercalcemia | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Parkinson Disease | 0.000271442 | 1 | 0 | BeFree |
Dermatologic disorders | 0.000271442 | 1 | 0 | BeFree |
Chagas Disease | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis, Pulmonary | 0.000271442 | 1 | 0 | BeFree |
Williams Syndrome | 0.000271442 | 1 | 0 | BeFree |
Abnormal mental state | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Breast adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mental handicap | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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