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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
[中文简述(自动翻译):]  该基因编码的蛋白是三方母题(TRIM)家族中的一员。 TRIM的基序包括三个锌结合结构域,一个环,B框型1和B框2型,和一个卷曲螺旋区域。此蛋白质定位于细胞质和其表达受干扰素诱导。来自HIV-1 LTR启动区域的蛋白下降调节的转录,这表明这种蛋白质是功能可以是介导干扰素的抗病毒效果。选择性剪接结果在多个抄本变形。 [由RefSeq的,2010年12月提供]
TRIM22基因(以及对应的蛋白质)的细胞分布位置:
TRIM22基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Influenza | 0.12 | 1 | 0 | CTD_human |
Infection | 0.00272435 | 1 | 0 | LHGDN |
HIV Infections | 0.001628651 | 6 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
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