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This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的三方母题(TRIM)家族中的一员。 TRIM的基序包括三个锌结合结构域,一个环,B框型1和B框2型,和一个卷曲螺旋区域。所编码的蛋白质是罗萨核糖核蛋白,它包括一个单一的多肽和四个小RNA分子中的一个的一部分。的罗萨颗粒定位于细胞质和细胞核两者。罗萨与患者舍格伦综合征和系统性红斑狼疮的自身抗原相互作用。此基因可变剪接转录物变体已有描述,但只有一个的全长性质已确定。 [由RefSeq的,2008年7月提供]
TRIM21基因(以及对应的蛋白质)的细胞分布位置:
TRIM21基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Lupus Erythematosus, Systemic | 0.022473594 | 55 | 5 | BeFree_GAD_LHGDN |
| Sjogren's Syndrome | 0.016445791 | 9 | 0 | BeFree_GAD_LHGDN |
| Autoimmune Diseases | 0.009520329 | 16 | 0 | BeFree_LHGDN |
| Neonatal Systemic lupus erythematosus | 0.007600372 | 28 | 0 | BeFree |
| Congenital heart block | 0.007328931 | 27 | 0 | BeFree |
| Lupus Erythematosus | 0.004885954 | 18 | 0 | BeFree |
| Lupus Erythematosus, Discoid | 0.003800186 | 14 | 0 | BeFree |
| Lupus Vulgaris | 0.003528744 | 13 | 0 | BeFree |
| Hyperplastic Polyp | 0.002985861 | 11 | 0 | BeFree |
| Sessile Serrated Adenoma/Polyp | 0.002985861 | 11 | 0 | BeFree |
| Squamous cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Cessation of life | 0.00272435 | 1 | 0 | LHGDN |
| Anemia, Sickle Cell | 0.002638474 | 1 | 1 | BeFree_GAD |
| polyps | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.002367032 | 1 | 0 | GAD |
| Adenoma | 0.001900093 | 7 | 0 | BeFree |
| Rheumatoid Arthritis | 0.001628651 | 6 | 0 | BeFree |
| Rheumatism | 0.001628651 | 6 | 0 | BeFree |
| Traditional Serrated Adenoma | 0.001628651 | 6 | 0 | BeFree |
| Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 1 | BeFree |
| Heart Block | 0.000814326 | 3 | 0 | BeFree |
| HIV Infections | 0.000814326 | 3 | 0 | BeFree |
| Lupus Erythematosus, Subacute Cutaneous | 0.000814326 | 3 | 0 | BeFree |
| Dermatologic disorders | 0.000814326 | 3 | 0 | BeFree |
| Dermatomyositis | 0.000542884 | 2 | 0 | BeFree |
| Familial Mediterranean Fever | 0.000542884 | 2 | 0 | BeFree |
| Pituitary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Adenomatous Polyposis Coli | 0.000542884 | 2 | 0 | BeFree |
| Sicca Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Primary Sj�gren's syndrome | 0.000542884 | 2 | 0 | BeFree |
| Multiple polyps | 0.000542884 | 2 | 0 | BeFree |
| Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
| Amyloidosis | 0.000271442 | 1 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Bronchiectasis | 0.000271442 | 1 | 0 | BeFree |
| Dermatitis | 0.000271442 | 1 | 0 | BeFree |
| Graves Disease | 0.000271442 | 1 | 0 | BeFree |
| Arthropathy | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukopenia | 0.000271442 | 1 | 0 | BeFree |
| Lung diseases | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
| Myositis | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Pleural effusion disorder | 0.000271442 | 1 | 0 | BeFree |
| Raynaud Disease | 0.000271442 | 1 | 0 | BeFree |
| Rectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| RNA Virus Infections | 0.000271442 | 1 | 0 | BeFree |
| Scarlet Fever | 0.000271442 | 1 | 0 | BeFree |
| Sialadenitis | 0.000271442 | 1 | 0 | BeFree |
| Skin lesion | 0.000271442 | 1 | 0 | BeFree |
| Gastric ulcer | 0.000271442 | 1 | 0 | BeFree |
| Thyroiditis | 0.000271442 | 1 | 0 | BeFree |
| Chagas Disease | 0.000271442 | 1 | 0 | BeFree |
| Viremia | 0.000271442 | 1 | 0 | BeFree |
| Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Adenomatous Polyps | 0.000271442 | 1 | 0 | BeFree |
| Adult type dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
| Annular Erythema | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Systemic amyloidosis | 0.000271442 | 1 | 0 | BeFree |
| Primary Systemic Amyloidosis | 0.000271442 | 1 | 0 | BeFree |
| Tubulovillous adenoma | 0.000271442 | 1 | 0 | BeFree |
| Streptococcal toxic shock syndrome | 0.000271442 | 1 | 0 | BeFree |
| Chronic Chagas' disease | 0.000271442 | 1 | 0 | BeFree |
| Immune thrombocytopenic purpura | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| lupus cutaneous | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Inflammatory Myopathies | 0.000271442 | 1 | 0 | BeFree |
| Alloimmunisation | 0.000271442 | 1 | 1 | BeFree |
| Lupus erythematosus overlap syndrome | 0.000271442 | 1 | 0 | BeFree |
| Rectal Tumors | 0.000271442 | 1 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
| PHOTOPAROXYSMAL RESPONSE 1 | 0.000271442 | 1 | 0 | BeFree |
| Subacute cutaneous lupus | 0.000271442 | 1 | 0 | BeFree |
| Serrated polyp | 0.000271442 | 1 | 0 | BeFree |
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