TNNC1(troponin C type 1 (slow))

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

3p21.1
基因染色体位置图

基因简述

基因简述

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

[中文简述(自动翻译):]  肌钙蛋白是横纹肌收缩的中央调节蛋白，并与原肌球蛋白一起，位于肌动蛋白丝。肌钙蛋白由3个亚基：肌钙蛋白，这是肌动球蛋白ATP酶活性的抑制剂; TNT，其中包含原肌球蛋白的结合位点;和TNC，由该基因编码的蛋白质。钙与肌钙蛋白结合废除肌钙蛋白的抑制作用，因此允许肌动蛋白与肌球蛋白的相互作用，ATP的水解，和张力的产生。在这种基因突变与心肌扩张型1Z相关联。 [由RefSeq的，2008年10月提供]

OMIM数据库中对TNNC1基因的介绍     Wikipedia数据库中对TNNC1基因的介绍

基因序列

基因序列

TNNC1基因的碱基序列：[NCBI]

基因突变

基因突变

TNNC1基因的碱基突变：           显示全部snp
rs724801       rs968588       rs1035002       rs1319202       rs2070914       rs2215466       rs3066889       rs3066892       rs3821838       rs3821839       rs58378554       rs71276876       rs75519250       rs80103411       rs112175699       rs112657817       rs112686091       rs116209740       rs116587848       rs143915662       rs145548845       rs181120784       rs184331696       rs184944814       rs188828914       rs189457410       rs201615917       rs368162215       rs528165909       rs528516744       rs528569236       rs529926194       rs532363311       rs532416341       rs534574427       rs535774478       rs537624736      
rs541160424       rs542168226       rs543591209       rs543599153       rs543662042       rs546100915       rs546163655       rs546891904       rs548163297       rs548315246       rs548700302       rs550716368       rs552560997       rs554619713       rs557148451       rs558120010       rs559474391       rs559570068       rs560909277       rs561753458       rs561942542       rs562620934       rs563472505       rs564549220       rs567110674       rs568105203       rs570750650       rs572040008       rs577140920       rs577147206       rs727503498       rs745423740       rs746893009       rs747920839       rs747976352       rs748590123       rs748823816       rs748830975       rs748999874       rs750452087       rs752094665       rs752114678       rs753256394       rs753335700       rs754478959       rs755429510       rs755678575       rs755696880       rs757795324       rs758816689       rs758938244       rs759828132       rs760719870       rs761588613       rs763465212       rs764491234       rs764761174       rs765431361       rs765668838       rs765934870       rs766433197       rs766629850       rs768318289       rs768499546       rs769524771       rs770581962       rs771049358       rs771851500       rs772045725       rs773192449       rs773976942       rs774355933       rs775249696       rs775754105       rs776536545       rs776926378       rs777330084       rs778497840       rs778604865       rs779361007       rs779540814       rs779812905       rs780786150       rs3755810       rs12497158       rs41292362       rs55995010       rs72965257       rs80101735       rs111352682       rs111372509       rs111972756       rs112004509       rs112232787       rs112971198       rs113124097       rs113599392       rs113708870       rs113940230       rs113940968       rs114152258       rs115688995       rs115716895       rs138757305       rs139003751       rs140287760       rs141289590       rs141505676       rs141880897       rs142519988       rs142759728       rs143020831       rs143694634       rs144626356       rs145066209       rs147821122       rs149428762       rs149647795       rs150715546       rs150881554       rs183307741       rs187842205       rs188248995       rs190993960       rs192260650       rs192641697       rs199523612       rs199709697       rs199851913       rs200066743       rs200296115       rs200430108       rs200621464       rs200926774       rs201112655       rs201813958       rs202000367       rs202173903       rs267607124       rs368863629       rs369241872       rs369639550       rs369787178       rs370103102       rs370426309       rs371023549       rs372975494       rs376202427       rs397516845       rs397516848       rs527396655       rs527986746       rs528971912       rs529935633       rs535124372       rs537331224       rs539004827       rs539117227       rs541885580       rs542220887       rs543093696       rs545564444       rs545578624       rs547590844       rs548837073       rs548983354       rs554135521       rs554783707       rs556411485       rs557550793       rs559120356       rs560076131       rs561182810       rs565480757       rs566390804       rs567327895       rs567630358       rs568828576       rs569009293       rs570041969       rs570104362       rs571171487       rs573992523       rs574990201       rs575019110       rs575666742       rs576631966       rs727503495       rs727503497       rs730880230       rs730881060       rs745782150       rs745846127       rs746269412       rs746394204       rs746663998       rs747202315       rs747741083       rs747842576       rs748288054       rs748414706       rs748913363       rs749235280       rs749367654       rs749736910       rs750085239       rs750230750       rs750647348       rs750960904       rs750978833       rs751018899       rs751682878       rs751920501       rs752066204       rs752100917       rs752347647       rs752678817       rs754280319       rs754343698       rs754572435       rs754800561       rs754928311       rs755269204       rs755337412       rs755805478       rs756286838       rs756483143       rs756513152       rs756860563       rs757105607       rs757250535       rs757464374       rs757904305       rs759210950       rs759472560       rs759981368       rs760268974       rs760637468       rs761287435       rs762823512       rs763016039       rs763584637       rs764114178       rs764129813       rs764547083       rs764835690       rs765114743       rs765306660       rs766106971       rs766116933       rs766904943       rs767111898       rs767523294       rs767979684       rs768019683       rs768178167       rs769155812       rs769720275       rs769919235       rs770134875       rs770331194       rs770343636       rs770807038       rs771216638       rs771327308       rs771484577       rs772247739       rs772372620       rs772571319       rs772752716       rs773410670       rs773462508       rs775387427       rs775842086       rs776392469       rs776484201       rs776989897       rs777445880       rs777568062       rs777928913       rs778230215       rs778692543       rs779067190       rs779157170       rs779922160       rs781245165       rs781712996      

基因表达

基因表达

TNNC1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TAATGCTGCAGGCTACAGG
60
CCAGGAACTCATCATAGTCGA
59
GGAGATGATCGATGAGGTG
57
CAGGAACTCATCAAAGTCCA
58
CCTCTTCCGCATGTTTGAC
59
TATCTTCAGCTCATCCAGGTC
59
TAATGCTGCAGGCTACAGG
60
TCCAGGAACTCATCATAGTCG
59
TGCAGGAGATGATCGATGAG
60
AACTCATCAAAGTCCACCGT
60
ATAATGCTGCAGGCTACAG
58
CCAGGAACTCATCATAGTCG
58
AGATGATCGATGAGGTGGAC
59
TTTGTCAAACATGCGGAAGAG
59
GATCGATGAGGTGGACGAG
59
TTTGTCAAACATGCGGAAGAG
59
CCTCTTCCGCATGTTTGAC
59
TATCTTCAGCTCATCCAGGT
58
CCTCTTCCGCATGTTTGAC
59
TTATCTTCAGCTCATCCAGGT
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

TNNC1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TNNC1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005509
C9JDI3(UniProtKB)
IEA
GO:0002086
P63316(UniProtKB)
IEA
GO:0005509
P63316(UniProtKB)
IDA
GO:0005509
P63316(UniProtKB)
IDA
GO:0005515
P63316(UniProtKB)
IPI
GO:0005654
P63316(UniProtKB)
IDA
GO:0005739
P63316(UniProtKB)
IDA
GO:0005829
P63316(UniProtKB)
TAS
GO:0005829
P63316(UniProtKB)
TAS
GO:0005829
P63316(UniProtKB)
TAS
GO:0005829
P63316(UniProtKB)
TAS
GO:0005861
P63316(UniProtKB)
IDA
GO:0005861
P63316(UniProtKB)
IDA
GO:0006937
P63316(UniProtKB)
IDA
GO:0006937
P63316(UniProtKB)
TAS
GO:0010038
P63316(UniProtKB)
IEA
GO:0014883
P63316(UniProtKB)
IEA
GO:0015629
P63316(UniProtKB)
IDA
GO:0030049
P63316(UniProtKB)
TAS
GO:0031013
P63316(UniProtKB)
IPI
GO:0031013
P63316(UniProtKB)
IPI
GO:0031013
P63316(UniProtKB)
IDA
GO:0031013
P63316(UniProtKB)
IPI
GO:0031014
P63316(UniProtKB)
IPI
GO:0031014
P63316(UniProtKB)
IPI
GO:0032972
P63316(UniProtKB)
ISS
GO:0042803
P63316(UniProtKB)
IDA
GO:0043462
P63316(UniProtKB)
ISS
GO:0048306
P63316(UniProtKB)
IPI
GO:0051015
P63316(UniProtKB)
ISS
GO:0055010
P63316(UniProtKB)
IMP
GO:0060048
P63316(UniProtKB)
IMP

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控TNNC1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Cardiomyopathy, Dilated, 1z 0.36 1 1 CLINVAR_CTD_human_UNIPROT
Cardiomyopathy, Familial Hypertrophic, 13 0.36 2 5 CLINVAR_CTD_human_UNIPROT
Cardiomyopathy, Dilated 0.133254501 12 2 BeFree_CLINVAR_GAD_LHGDN
Cardiomyopathy, Familial Hypertrophic, 1 (disorder) 0.12 0 0 CTD_human
Hypertrophic Cardiomyopathy 0.009901391 11 3 BeFree_GAD_LHGDN
Cardiomyopathies 0.004895885 8 2 BeFree_LHGDN
Restrictive cardiomyopathy 0.00272435 1 0 LHGDN
Cardiomyopathy, Familial Idiopathic 0.000814326 3 0 BeFree
Disorder of Achilles tendon 0.000814326 3 0 BeFree
Squamous cell carcinoma 0.000542884 2 0 BeFree
Neoplasm Metastasis 0.000542884 2 0 BeFree
Degenerative polyarthritis 0.000542884 2 0 BeFree
Systemic Scleroderma 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Extrinsic allergic alveolitis 0.000271442 1 0 BeFree
Asthma 0.000271442 1 0 BeFree
Autistic Disorder 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Dentinogenesis Imperfecta 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Heart failure 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Osteogenesis Imperfecta 0.000271442 1 0 BeFree
Pulmonary Fibrosis 0.000271442 1 0 BeFree
Rubinstein-Taybi Syndrome 0.000271442 1 0 BeFree
Proliferative diabetic retinopathy 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Familial dilated cardiomyopathy 0.000271442 1 5 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000271442 1 0 BeFree
Idiopathic Pulmonary Fibrosis 0.000271442 1 0 BeFree

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