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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是TNF受体超家族的成员。该受体有助于克隆扩增,存活,和T细胞的发展。它也可以诱导细胞增殖外周血单核细胞,增强T通过TCR / CD3诱导的细胞凋亡触发激活和调节CD28共同刺激,促进Th1型细胞反应。该受体的表达是由淋巴细胞活化诱导。 TRAF衔接蛋白已显示出结合到该受体和转导导致的NF-κB的激活的信号。 [由RefSeq的,2008年7月提供]
TNFRSF9基因(以及对应的蛋白质)的细胞分布位置:
TNFRSF9基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Colonic Neoplasms | 0.12 | 1 | 0 | CTD_human |
Kidney Neoplasm | 0.12 | 1 | 0 | CTD_human |
Stomach Neoplasms | 0.12 | 1 | 0 | CTD_human |
Rheumatoid Arthritis | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Colorectal Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Liver carcinoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Crohn Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Inflammation | 0.00272435 | 1 | 0 | LHGDN |
Systemic Scleroderma | 0.00272435 | 1 | 0 | LHGDN |
Multiple Myeloma | 0.002638474 | 2 | 0 | BeFree_GAD |
Celiac Disease | 0.002367032 | 1 | 1 | GAD |
Tumor Immunity | 0.001357209 | 5 | 0 | BeFree |
Autoimmune Diseases | 0.001085767 | 4 | 0 | BeFree |
melanoma | 0.001085767 | 4 | 0 | BeFree |
Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Asthma | 0.000542884 | 2 | 0 | BeFree |
Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
Influenza | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Chordoma | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Mycobacterium avium-intracellulare Infection | 0.000271442 | 1 | 0 | BeFree |
Myocarditis | 0.000271442 | 1 | 0 | BeFree |
Nasal Polyps | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
Diabetes, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Lewis Lung | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of colon stage IV | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Idiopathic eosinophilia | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B, Chronic | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Acute Coronary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Eosinophilic disorder | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
IgE-mediated allergic asthma | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
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