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This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
[中文简述(自动翻译):] 该基因属于肿瘤坏死因子受体超家族。所编码的蛋白质是假设在抑制FasL-和LIGHT介导的细胞死亡中发挥调节作用。它作为与死亡受体配体结合竞争的诱饵受体。该基因的过表达已在胃肠道肿瘤已经注意到。通读转录成从相邻的上游基因,其编码端粒伸长旋酶1(RTEL1)的调节器,产生一个非编码转录本的基因。 [由RefSeq的,2011年2月提供]
TNFRSF6B基因(以及对应的蛋白质)的细胞分布位置:
TNFRSF6B基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Rheumatoid Arthritis | 0.006720033 | 6 | 0 | BeFree_GAD_LHGDN |
IGA Glomerulonephritis | 0.005634266 | 2 | 0 | BeFree_GAD_LHGDN |
Inflammatory Bowel Diseases | 0.005634266 | 3 | 1 | BeFree_GAD_LHGDN |
Stomach Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Neoplasm Metastasis | 0.004895885 | 9 | 0 | BeFree_LHGDN |
Alzheimer's Disease | 0.004734064 | 2 | 0 | GAD |
Glioblastoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Lymphoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Liver carcinoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Lupus Erythematosus, Systemic | 0.003452799 | 5 | 0 | BeFree_GAD |
Autoimmune Diseases | 0.003267234 | 3 | 0 | BeFree_LHGDN |
B-Cell Lymphomas | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Brain Neoplasms | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Colorectal Neoplasms | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Glomerulonephritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Crohn Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
Arthritis | 0.00272435 | 1 | 0 | LHGDN |
Ulcerative Colitis | 0.002638474 | 2 | 1 | BeFree_GAD |
Malignant neoplasm of lung | 0.002638474 | 2 | 0 | BeFree_GAD |
Squamous cell carcinoma | 0.002367032 | 1 | 0 | GAD |
Esophageal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of esophagus | 0.002367032 | 1 | 0 | GAD |
Pancreatic carcinoma | 0.001628651 | 6 | 0 | BeFree |
Carcinogenesis | 0.001628651 | 6 | 0 | BeFree |
Tumor Progression | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.001357209 | 5 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.001085767 | 4 | 2 | BeFree |
Secondary malignant neoplasm of lymph node | 0.001085767 | 4 | 0 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Silicosis | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Bone Diseases | 0.000271442 | 1 | 0 | BeFree |
Burkitt Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Empyema, Pleural | 0.000271442 | 1 | 0 | BeFree |
Herpes NOS | 0.000271442 | 1 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Psoriasis | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
gliosarcoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Tumor necrosis | 0.000271442 | 1 | 0 | BeFree |
Malignant Fibrous Histiocytoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Idiopathic crescentic glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
IMMUNE SUPPRESSION | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
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