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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是TNF受体超家族的成员。这种受体胚胎发育过程中高度表达。它已被证明与TRAF家族成员相互作用,并在细胞中过表达时,激活的JNK信号传导途径。这种受体是能够通过胱天蛋白酶非依赖性机制诱导细胞凋亡的,并且它被认为在胚胎发育中起重要作用。编码不同同种型的可变剪接转录物变体已有描述。 [由RefSeq的,2008年7月提供]
TNFRSF19基因(以及对应的蛋白质)的细胞分布位置:
TNFRSF19基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| melanoma | 0.122995792 | 1 | 0 | BeFree_CTD_human_LHGDN |
| Nasopharyngeal Neoplasms | 0.122367032 | 1 | 1 | CTD_human_GAD |
| Nasopharyngeal carcinoma | 0.120271442 | 1 | 1 | BeFree_GWASCAT |
| Multiple Sclerosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Lung Neoplasms | 0.002367032 | 1 | 1 | GAD |
| Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Intestinal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 6 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 6 | BeFree |
| Primary Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
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