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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是TNF受体超家族的成员。这种蛋白质是成骨细胞分泌的诱饵受体,其功能如同骨吸收的负调节。该蛋白质特异性结合到其配体,护骨配体,这两者都是破骨细胞发育的关键细胞外调节。鼠标对口研究还表明,这种蛋白质和其配体发挥淋巴结器官发生和血管钙化作用。这个基因的可变剪接转录物变体已有报道,但是它们的全长性质尚未确定。 [由RefSeq的,2008年7月提供]
TNFRSF11B基因(以及对应的蛋白质)的细胞分布位置:
TNFRSF11B基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hyperphosphatasemia with bone disease | 0.362171535 | 8 | 4 | BeFree_CLINVAR_CTD_human_ORPHANET |
| Arthritis, Experimental | 0.2 | 2 | 0 | CTD_human_RGD |
| Osteoporosis | 0.169854342 | 64 | 2 | BeFree_CTD_human_GAD_LHGDN |
| Rheumatoid Arthritis | 0.138878836 | 24 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Inflammation | 0.125091382 | 3 | 0 | CTD_human_GAD_LHGDN |
| Hypercalcemia | 0.120814326 | 4 | 0 | BeFree_CTD_human |
| Uremia | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Bone Resorption | 0.12 | 3 | 0 | CTD_human |
| Hyperalgesia | 0.12 | 1 | 0 | CTD_human |
| Lytic lesion | 0.12 | 1 | 0 | CTD_human |
| Heart failure | 0.080271442 | 2 | 0 | BeFree_RGD |
| Myocarditis | 0.08 | 1 | 0 | RGD |
| Periapical Diseases | 0.08 | 1 | 0 | RGD |
| Osteoporosis, Postmenopausal | 0.016274038 | 10 | 0 | BeFree_GAD_LHGDN |
| Bone Diseases | 0.012516121 | 19 | 0 | BeFree_LHGDN |
| Periodontitis | 0.011996981 | 9 | 0 | BeFree_GAD_LHGDN |
| Multiple Myeloma | 0.010606096 | 20 | 0 | BeFree_LHGDN |
| Degenerative polyarthritis | 0.009705894 | 19 | 0 | BeFree_GAD_LHGDN |
| Mammary Neoplasms | 0.008715934 | 5 | 0 | BeFree_LHGDN |
| Malignant neoplasm of prostate | 0.00853425 | 14 | 0 | BeFree_GAD |
| Juvenile arthritis | 0.008444493 | 3 | 0 | BeFree_LHGDN |
| Cardiovascular Diseases | 0.008434561 | 13 | 0 | BeFree_LHGDN |
| Prostatic Neoplasms | 0.008173051 | 3 | 0 | LHGDN |
| Kidney Failure, Chronic | 0.008087174 | 4 | 0 | BeFree_GAD_LHGDN |
| Osteosclerosis | 0.00680591 | 5 | 0 | BeFree_LHGDN |
| Coronary Artery Disease | 0.006534468 | 6 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.006524536 | 15 | 0 | BeFree_LHGDN |
| Secondary malignant neoplasm of bone | 0.005971721 | 22 | 0 | BeFree |
| Hypertensive disease | 0.005905708 | 5 | 0 | BeFree_GAD_LHGDN |
| Left Ventricular Hypertrophy | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
| Obesity | 0.00554839 | 3 | 1 | BeFree_GAD |
| Diabetes Mellitus | 0.005438769 | 10 | 0 | BeFree_LHGDN |
| Osteitis Deformans | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
| Atherosclerosis | 0.004895885 | 9 | 0 | BeFree_LHGDN |
| Osteosarcoma | 0.004624443 | 8 | 0 | BeFree_LHGDN |
| Malignant neoplasm of breast | 0.004614512 | 17 | 0 | BeFree |
| Breast Carcinoma | 0.004614512 | 17 | 0 | BeFree |
| Chronic Periodontitis | 0.004353001 | 7 | 0 | BeFree_LHGDN |
| Coronary Arteriosclerosis | 0.003995683 | 6 | 0 | BeFree_GAD |
| Primary Myelofibrosis | 0.003810118 | 4 | 0 | BeFree_LHGDN |
| Coronary heart disease | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Endometriosis | 0.003538676 | 3 | 0 | BeFree_LHGDN |
| Diabetic Nephropathy | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Liver diseases | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Prostate carcinoma | 0.003257302 | 12 | 0 | BeFree |
| Arthritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Multiple Sclerosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Myocardial Infarction | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Periapical Granuloma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Periodontitis, Juvenile | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Vascular Diseases | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Myocardial Ischemia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Spondylarthritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Lupus Erythematosus, Systemic | 0.002909916 | 3 | 0 | BeFree_GAD |
| Amenorrhea | 0.00272435 | 1 | 0 | LHGDN |
| Aortic Valve Stenosis | 0.00272435 | 1 | 0 | LHGDN |
| Cardiomyopathy, Dilated | 0.00272435 | 1 | 0 | LHGDN |
| Carotid Stenosis | 0.00272435 | 1 | 0 | LHGDN |
| Glioma | 0.00272435 | 1 | 0 | LHGDN |
| Glomerulonephritis | 0.00272435 | 1 | 0 | LHGDN |
| Hemorrhage | 0.00272435 | 1 | 0 | LHGDN |
| HTLV-I Infections | 0.00272435 | 1 | 0 | LHGDN |
| Hypothyroidism | 0.00272435 | 1 | 0 | LHGDN |
| Acute Megakaryocytic Leukemias | 0.00272435 | 1 | 0 | LHGDN |
| Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Polycythemia Vera | 0.00272435 | 1 | 0 | LHGDN |
| Venous Thrombosis | 0.00272435 | 1 | 0 | LHGDN |
| Disease Progression | 0.00272435 | 1 | 0 | LHGDN |
| Acute Coronary Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Diabetes Mellitus, Insulin-Dependent | 0.002638474 | 2 | 1 | BeFree_GAD |
| Diabetic Neuropathies | 0.002638474 | 2 | 0 | BeFree_GAD |
| Diarrhea | 0.002638474 | 2 | 0 | BeFree_GAD |
| Gaucher Disease | 0.002638474 | 1 | 0 | BeFree_GAD |
| Cerebrovascular accident | 0.002638474 | 1 | 0 | BeFree_GAD |
| Alzheimer's Disease | 0.002367032 | 1 | 0 | GAD |
| Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
| Escherichia coli Infections | 0.002367032 | 1 | 0 | GAD |
| Pathological fracture | 0.002367032 | 1 | 0 | GAD |
| Blood pressure finding | 0.002367032 | 1 | 1 | GAD |
| Systemic arterial pressure | 0.002367032 | 1 | 1 | GAD |
| Paget's Disease | 0.002367032 | 1 | 0 | GAD |
| Cerebral Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Arteriosclerosis | 0.002171535 | 8 | 0 | BeFree |
| Diabetes | 0.002171535 | 8 | 0 | BeFree |
| bone destruction | 0.001900093 | 7 | 0 | BeFree |
| Osteosarcoma of bone | 0.001900093 | 7 | 0 | BeFree |
| Bone neoplasms | 0.001628651 | 6 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.001357209 | 5 | 1 | BeFree |
| Osteopetrosis | 0.001357209 | 5 | 0 | BeFree |
| Giant Cell Tumor of Bone | 0.001357209 | 5 | 0 | BeFree |
| Otosclerosis | 0.001085767 | 4 | 0 | BeFree |
| Superficial ulcer | 0.001085767 | 4 | 0 | BeFree |
| Aortic Aneurysm | 0.000814326 | 3 | 0 | BeFree |
| Aortic Aneurysm, Abdominal | 0.000814326 | 3 | 0 | BeFree |
| Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
| Chronic Kidney Insufficiency | 0.000814326 | 3 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Dissecting aneurysm of the thoracic aorta | 0.000814326 | 3 | 0 | BeFree |
| Central Core Myopathy (disorder) | 0.000814326 | 3 | 0 | BeFree |
| Aortic calcification | 0.000814326 | 3 | 0 | BeFree |
| Chronic Kidney Diseases | 0.000814326 | 3 | 0 | BeFree |
| Bacterial Infections | 0.000542884 | 2 | 0 | BeFree |
| Diabetic Angiopathies | 0.000542884 | 2 | 0 | BeFree |
| Giant Cell Tumors | 0.000542884 | 2 | 0 | BeFree |
| Gingival Diseases | 0.000542884 | 2 | 0 | BeFree |
| Hyperparathyroidism | 0.000542884 | 2 | 0 | BeFree |
| Liver Cirrhosis | 0.000542884 | 2 | 0 | BeFree |
| Myelofibrosis | 0.000542884 | 2 | 0 | BeFree |
| Periodontal Diseases | 0.000542884 | 2 | 0 | BeFree |
| Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
| Hyperparathyroidism, Primary | 0.000542884 | 2 | 2 | BeFree |
| Osteopenia/osteoporosis | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000542884 | 2 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
| Osteoarthritis, Knee | 0.000542884 | 2 | 0 | BeFree |
| Adolescent idiopathic scoliosis | 0.000542884 | 2 | 0 | BeFree |
| Familial expansile osteolysis | 0.000542884 | 2 | 0 | BeFree |
| Metabolic Syndrome X | 0.000542884 | 2 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Peri-Implantitis | 0.000542884 | 2 | 0 | BeFree |
| Abdominal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Anemia | 0.000271442 | 1 | 0 | BeFree |
| Aneurysm | 0.000271442 | 1 | 0 | BeFree |
| Angina, Unstable | 0.000271442 | 1 | 0 | BeFree |
| Angioid Streaks | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Palsy | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Craniosynostosis | 0.000271442 | 1 | 0 | BeFree |
| Epidermodysplasia Verruciformis | 0.000271442 | 1 | 0 | BeFree |
| Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
| Hyperlipidemia | 0.000271442 | 1 | 0 | BeFree |
| Hyperparathyroidism, Secondary | 0.000271442 | 1 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Pain | 0.000271442 | 1 | 0 | BeFree |
| Periostitis | 0.000271442 | 1 | 0 | BeFree |
| Progeria | 0.000271442 | 1 | 0 | BeFree |
| Ankylosing spondylitis | 0.000271442 | 1 | 0 | BeFree |
| Tuberous Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Turner Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Viral hepatitis | 0.000271442 | 1 | 0 | BeFree |
| Vitamin D Deficiency | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Essential Hypertension | 0.000271442 | 1 | 0 | BeFree |
| Benign Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Corneal pannus | 0.000271442 | 1 | 0 | BeFree |
| Acute myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
| Neuroendocrine Tumors | 0.000271442 | 1 | 0 | BeFree |
| Tophus | 0.000271442 | 1 | 0 | BeFree |
| Fibrillation | 0.000271442 | 1 | 0 | BeFree |
| Paroxysmal atrial fibrillation | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Osteoarthritis of the hand | 0.000271442 | 1 | 0 | BeFree |
| Non-small cell lung cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Stable angina | 0.000271442 | 1 | 0 | BeFree |
| Aortic aneurysm without mention of rupture NOS | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Osteoarthritis of distal interphalangeal joint | 0.000271442 | 1 | 0 | BeFree |
| Primary osteoporosis | 0.000271442 | 1 | 0 | BeFree |
| Aortic valve calcification | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Calcium pyrophosphate deposition disease | 0.000271442 | 1 | 0 | BeFree |
| Carotid Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Lymphangioleiomyomatosis | 0.000271442 | 1 | 0 | BeFree |
| Bacterial diarrhoea | 0.000271442 | 1 | 0 | BeFree |
| 21-hydroxylase deficiency | 0.000271442 | 1 | 0 | BeFree |
| Oestrogen deficiency | 0.000271442 | 1 | 0 | BeFree |
| Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
| Cardiovascular morbidity | 0.000271442 | 1 | 0 | BeFree |
| Pyrophosphate arthritis | 0.000271442 | 1 | 0 | BeFree |
| Peripheral arterial occlusive disease | 0.000271442 | 1 | 0 | BeFree |
| Osteogenic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Primary Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Congenital adrenal hyperplasia due to 21 hydroxylase deficiency | 0.000271442 | 1 | 0 | BeFree |
| Limb ischemia | 0.000271442 | 1 | 0 | BeFree |
| Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Juvenile rheumatoid arthritis | 0.000271442 | 1 | 0 | BeFree |
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