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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是TNF受体超家族的成员。该受体包含胞外TRAIL结合结构域和跨膜结构域,但没有胞质死亡域。该受体是不能够诱导细胞凋亡的,并且被认为充当保护细胞免于TRAIL诱导的细胞凋亡的拮抗受体。该基因被认为是一个p53-调节的DNA损伤 - 诱导型基因。在许多正常组织中检测到该基因的表达,但在大多数肿瘤细胞系,这可以解释癌细胞的具体灵敏度对TRAIL的细胞凋亡诱导活性。 [由RefSeq的,2008年7月提供]
TNFRSF10C基因(以及对应的蛋白质)的细胞分布位置:
TNFRSF10C基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
| Prostatic Neoplasms | 0.005720142 | 2 | 0 | BeFree_LHGDN |
| Churg-Strauss Syndrome | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Eosinophilia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Leukemia, Myelocytic, Acute | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Pancreatitis, Chronic | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of breast | 0.002638474 | 2 | 0 | BeFree_GAD |
| Multiple Myeloma | 0.002367032 | 1 | 0 | GAD |
| Down Syndrome | 0.000814326 | 3 | 0 | BeFree |
| Glioma | 0.000814326 | 3 | 0 | BeFree |
| melanoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
| Mental Retardation | 0.000542884 | 2 | 0 | BeFree |
| Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cystadenoma | 0.000271442 | 1 | 0 | BeFree |
| Hypercholesterolemia, Familial | 0.000271442 | 1 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukopenia | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Neutropenia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
| Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Dysmorphic features | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Partial Trisomy | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilic disorder | 0.000271442 | 1 | 0 | BeFree |
| Disorder characterized by eosinophilia | 0.000271442 | 1 | 0 | BeFree |
| DOWN SYNDROME CRITICAL REGION | 0.000271442 | 1 | 0 | BeFree |
| Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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